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Antibiotic prescribing in primary care and antimicrobial resistance in patients admitted to hospital with urinary tract infection: a controlled observational pilot study

Costelloe, Ceire; Williams, O. Martin; Montgomery, Alan A.; Dayan, Colin; Hay, Alastair D.

Authors

Ceire Costelloe

O. Martin Williams

Alan A. Montgomery

Colin Dayan

Alastair D. Hay

Abstract

There is growing evidence that primary care prescribed antibiotics lead to antibiotic resistance in bacteria causing minor infections or being carried by asymptomatic adults, but little research to date has investigated links between primary care prescribed antibiotics and resistance among more serious infections requiring hospital care. Knowledge of these effects is likely to have a major influence on public expectations for, and primary care use of, antibiotics. This study aimed to assess the feasibility of recruiting symptomatic adult patients admitted to hospital with urinary infections and to link primary and secondary data information to investigate the relationship between primary care prescribed antibiotics and antimicrobial resistance in these patients. A microbiology database search of in patients who had submitted a urine sample identified 740 patients who were potentially eligible to take part in the study. Of these, 262 patients did not meet the eligibility criteria, mainly due to use of a urinary catheter (40%). Two-hundred and forty three patients could not be recruited as the nurse was unable to visit the patients prior to discharge, as they were too unwell. Eighty patients provided complete information. Results indicate that there is evidence that prior antibiotic use is associated with resistant infections in hospital patients. A fully powered study, conducted using routinely collected data is proposed to fully clarify the precision of the association.

Journal Article Type Article
Publication Date Jan 22, 2014
Journal Antibiotics
Electronic ISSN 2079-6382
Publisher MDPI
Peer Reviewed Peer Reviewed
Volume 3
Issue 1
Institution Citation Costelloe, C., Williams, O. M., Montgomery, A. A., Dayan, C., & Hay, A. D. (2014). Antibiotic prescribing in primary care and antimicrobial resistance in patients admitted to hospital with urinary tract infection: a controlled observational pilot study. Antibiotics, 3(1), doi:10.3390/antibiotics3010029
DOI https://doi.org/10.3390/antibiotics3010029
Publisher URL http://www.mdpi.com/2079-6382/3/1/29
Copyright Statement Copyright information regarding this work can be found at the following address: http://creativecommons.org/licenses/by/4.0

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