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Helicobacter pylori vacA transcription is genetically-determined and stratifies the level of human gastric inflammation and atrophy (2016)
Journal Article
Sinnett, C. G., Letley, D. P., Narayana, G. L., Patel, S. R., Hussein, N. R., Zaitoun, A. M., …Atherton, J. C. (2016). Helicobacter pylori vacA transcription is genetically-determined and stratifies the level of human gastric inflammation and atrophy. Journal of Clinical Pathology, 69(11), 968-973. https://doi.org/10.1136/jclinpath-2016-203641

Aims Helicobacter pylori infection is the major cause of peptic ulceration and gastric cancer, and an important virulence determinant is its vacuolating cytotoxin, vacA. Previously, we have described allelic variation in vacA which determines toxin a... Read More about Helicobacter pylori vacA transcription is genetically-determined and stratifies the level of human gastric inflammation and atrophy.

The influence of nanotexturing of poly(lactic-co-glycolic acid) films upon human ovarian cancer cell attachment (2016)
Journal Article
Ya?ayan, G., Xue, X., Collier, P., Clarke, P., Alexander, M. R., & Marlow, M. (2016). The influence of nanotexturing of poly(lactic-co-glycolic acid) films upon human ovarian cancer cell attachment. Nanotechnology, 27(25), https://doi.org/10.1088/0957-4484/27/25/255102

In this study, we have produced nanotextured poly(lactic-co-glycolic acid) (PLGA) films by using polystyrene (PS) particles as a template to make a polydimethylsiloxane mould against which PLGA is solvent cast. Biocompatible, biodegradable and nanote... Read More about The influence of nanotexturing of poly(lactic-co-glycolic acid) films upon human ovarian cancer cell attachment.

Historical and contemporary stable isotope tracer approaches to studying mammalian protein metabolism (2016)
Journal Article
Wilkinson, D. J. (in press). Historical and contemporary stable isotope tracer approaches to studying mammalian protein metabolism. Mass Spectrometry Reviews, https://doi.org/10.1002/mas.21507

Over a century ago, Frederick Soddy provided the first evidence for the existence of isotopes; elements that occupy the same position in the periodic table are essentially chemically identical but differ in mass due to a different number of neutrons... Read More about Historical and contemporary stable isotope tracer approaches to studying mammalian protein metabolism.

Personalised long-term follow-up of cochlear implant patients using remote care, compared with those on the standard care pathway: study protocol for a feasibility randomised controlled trial (2016)
Journal Article
Cullington, H., Kitterick, P. T., DeBold, L., Weal, M., Clarke, N., Newberry, E., & Aubert, L. (in press). Personalised long-term follow-up of cochlear implant patients using remote care, compared with those on the standard care pathway: study protocol for a feasibility randomised controlled trial. BMJ Open, 6(5), Article e011342. https://doi.org/10.1136/bmjopen-2016-011342

Introduction: Many resources are required to provide postoperative care to patients who receive a cochlear implant. The implant service commits to lifetime follow-up. The patient commits to regular adjustment and rehabilitation appointments in the fi... Read More about Personalised long-term follow-up of cochlear implant patients using remote care, compared with those on the standard care pathway: study protocol for a feasibility randomised controlled trial.

How integrated are neurology and palliative care services? Results of a multicentre mapping exercise (2016)
Journal Article
van Vliet, L. M., Gao, W., DiFrancesco, D., Crosby, V., Wilcock, A., Byrne, A., …Higginson, I. J. (in press). How integrated are neurology and palliative care services? Results of a multicentre mapping exercise. BMC Neurology, 16, https://doi.org/10.1186/s12883-016-0583-6

Background: Patients affected by progressive long-term neurological conditions might benefit from specialist palliative care involvement. However, little is known on how neurology and specialist palliative care services interact. This study aimed to... Read More about How integrated are neurology and palliative care services? Results of a multicentre mapping exercise.

Benefits to speech perception in noise from the binaural integration of electric and acoustic signals in simulated unilateral deafness (2016)
Journal Article
Ma, N., Morris, S. D., & Kitterick, P. T. (in press). Benefits to speech perception in noise from the binaural integration of electric and acoustic signals in simulated unilateral deafness. Ear and Hearing, 37(3), https://doi.org/10.1097/AUD.0000000000000252

Objectives: This study used vocoder simulations with normal-hearing (NH) listeners to (a) measure their ability to integrate speech information from a NH ear and a simulated cochlear implant (CI); and (b) investigate whether binaural integration is d... Read More about Benefits to speech perception in noise from the binaural integration of electric and acoustic signals in simulated unilateral deafness.

Mortality of emergency abdominal surgery in high-, middle- and low-income countries (2016)
Journal Article
GlobalSurg Collaborative. (2016). Mortality of emergency abdominal surgery in high-, middle- and low-income countries. British Journal of Surgery, 103(8), https://doi.org/10.1002/bjs.10151

Background: Surgical mortality data are collected routinely in high-income countries, yet virtually no low- or middle-income countries have outcome surveillance in place. The aim was prospectively to collect worldwide mortality data following emergen... Read More about Mortality of emergency abdominal surgery in high-, middle- and low-income countries.

Applying theories of health behaviour and change to hearing health research: time for a new approach (2016)
Journal Article
Coulson, N. S., Ferguson, M. A., Henshaw, H., & Heffernan, E. (in press). Applying theories of health behaviour and change to hearing health research: time for a new approach. International Journal of Audiology, 55(sup3), Article S99-S104. https://doi.org/10.3109/14992027.2016.1161851

Objective: In recent years, there has been an increase in the application of behavioural models, such as social cognition models, to the promotion of hearing health. Despite this, there exists a well-developed body of literature that suggests such m... Read More about Applying theories of health behaviour and change to hearing health research: time for a new approach.

A systematic review, evidence synthesis and meta-analysis of quantitative and qualitative studies evaluating the clinical effectiveness, the cost-effectiveness, safety and acceptability of interventions to prevent postnatal depression (2016)
Journal Article
Morrell, C. J., Sutcliffe, P., Booth, A., Stevens, J., Scope, A., Stevenson, M., …Stewart-Brown, S. (2016). A systematic review, evidence synthesis and meta-analysis of quantitative and qualitative studies evaluating the clinical effectiveness, the cost-effectiveness, safety and acceptability of interventions to prevent postnatal depression. Health Technology Assessment, 20(37), 1-414. https://doi.org/10.3310/hta20370

Background: Postnatal depression (PND) is a major depressive disorder in the year following childbirth, which impacts on women, their infants and their families. A range of interventions has been developed to prevent PND. Objectives: To (1) evaluate... Read More about A systematic review, evidence synthesis and meta-analysis of quantitative and qualitative studies evaluating the clinical effectiveness, the cost-effectiveness, safety and acceptability of interventions to prevent postnatal depression.

Scoping systematic review of treatments for eczema (2016)
Journal Article
Nankervis, H., Thomas, K., Delamere, F. M., Barbarot, S., Rogers, N. K., & Williams, H. C. (2016). Scoping systematic review of treatments for eczema. Programme Grants for Applied Research, 4(7), https://doi.org/10.3310/pgfar04070

Background: Eczema is a very common chronic inflammatory skin condition. Objectives: To update the National Institute for Health Research (NIHR) Health Technology Assessment (HTA) systematic review of treatments for atopic eczema, published in 2000,... Read More about Scoping systematic review of treatments for eczema.

Enriching a protein drink with leucine augments muscle protein synthesis after resistance exercise in young and older men (2016)
Journal Article
Atherton, P. J., Kumar, V., Selby, A. L., Rankin, D., Hildebrandt, W., Phillips, B. E., …Smith, K. (2017). Enriching a protein drink with leucine augments muscle protein synthesis after resistance exercise in young and older men. Clinical Nutrition, 36(3), 888-895. https://doi.org/10.1016/j.clnu.2016.04.025

© 2016 Elsevier Ltd and European Society for Clinical Nutrition and Metabolism Maximizing anabolic responses to feeding and exercise is crucial for muscle maintenance and adaptation to exercise training. We hypothesized that enriching a protein drink... Read More about Enriching a protein drink with leucine augments muscle protein synthesis after resistance exercise in young and older men.

Development and clinical acceptability of a pre-operative risk stratification tool of cerebellar mutism syndrome in children with posterior fossa tumour (2016)
Conference Proceeding
Dineen, R. A., Avula, S., Chambers, T., Dutta, M., Liu, J., Soria, D., …Walker, D. (2016). Development and clinical acceptability of a pre-operative risk stratification tool of cerebellar mutism syndrome in children with posterior fossa tumour.

Aims: Despite identification of numerous pre-operative cerebellar mutism syndrome (CMS) clinical and radiological predictors, a unifying pre-operative risk stratification model for use during surgical consent is currently lacking. The aims of the pro... Read More about Development and clinical acceptability of a pre-operative risk stratification tool of cerebellar mutism syndrome in children with posterior fossa tumour.

Three-dimensional ex vivo co-culture models of the leukaemic bone marrow niche for functional drug testing (2016)
Journal Article
Dhami, S. P. S., Kappala, S. S., Thompson, A., & Szegezdi, E. (in press). Three-dimensional ex vivo co-culture models of the leukaemic bone marrow niche for functional drug testing. Drug Discovery Today, 21(9), https://doi.org/10.1016/j.drudis.2016.04.019

Acute myeloid leukaemia (AML) is a hierarchically structured malignancy in which aberrant leukemic stem cells drive the production of leukaemic blast cell clones. AML cells strictly depend on the bone marrow microenvironment (BMM) in which they resid... Read More about Three-dimensional ex vivo co-culture models of the leukaemic bone marrow niche for functional drug testing.

Nottingham prognostic index plus (NPI+) predicts risk of distant metastases in primary breast cancer (2016)
Journal Article
Green, A. R., Soria, D., Powe, D. G., Nolan, C. C., Aleskandarany, M. A., Szász, M., …Ellis, I. O. (2016). Nottingham prognostic index plus (NPI+) predicts risk of distant metastases in primary breast cancer. Breast Cancer Research and Treatment, 157(1), 65-75. https://doi.org/10.1007/s10549-016-3804-1

The Nottingham prognostic index plus (NPI+) is based on the assessment of biological class combined with established clinicopathologic prognostic variables providing improved patient outcome stratification for breast cancer superior to the traditiona... Read More about Nottingham prognostic index plus (NPI+) predicts risk of distant metastases in primary breast cancer.

Access to aidable residual hearing in adult candidates for cochlear implantation in the UK (2016)
Journal Article
Fielden, C. A., Hampton, R., Smith, S., & Kitterick, P. T. (in press). Access to aidable residual hearing in adult candidates for cochlear implantation in the UK. Cochlear Implants International, 17(sup 1), https://doi.org/10.1080/14670100.2016.1153836

Guidance from the National Institute for Health and Care Excellence (NICE) permits candidates to receive a cochlear implant provided they only hear sounds louder than 90 dB HL at 2 and 4 kHz. In some patients, their level of residual hearing may be s... Read More about Access to aidable residual hearing in adult candidates for cochlear implantation in the UK.

Choosing which ear to implant in adult candidates with functional residual hearing (2016)
Journal Article
Fielden, C. A., Mehta, R. L., & Kitterick, P. T. (in press). Choosing which ear to implant in adult candidates with functional residual hearing. Cochlear Implants International, 17(sup1), https://doi.org/10.1080/14670100.2016.1155805

This study examined whether audiologists consider the potential benefits of contralateral hearing aid use following cochlear implantation when recommending which ear to implant in UK adult candidates with residual hearing. Thirty-four audiologists fr... Read More about Choosing which ear to implant in adult candidates with functional residual hearing.

Predicting speech perception outcomes following cochlear implantation in adults with unilateral deafness or highly asymmetric hearing loss (2016)
Journal Article
Kitterick, P. T., & Lucas, L. (in press). Predicting speech perception outcomes following cochlear implantation in adults with unilateral deafness or highly asymmetric hearing loss. Cochlear Implants International, 17(sup 1), https://doi.org/10.1080/14670100.2016.1155806

Unilateral deafness and highly-asymmetric hearing loss can impair listening abilities in everyday situations, create substantial audiological handicap, and reduce overall quality of life. Preliminary evidence from early-phase studies in adults sugges... Read More about Predicting speech perception outcomes following cochlear implantation in adults with unilateral deafness or highly asymmetric hearing loss.

Preliminary assessment of the feasibility of using AB words to assess candidacy in adults (2016)
Journal Article
Vickers, D. A., Riley, A., Ricaud, R., Verschuur, C., Cooper, S., Nunn, T., …Kitterick, P. T. (in press). Preliminary assessment of the feasibility of using AB words to assess candidacy in adults. Cochlear Implants International, 17(sup 1), https://doi.org/10.1080/14670100.2016.1161143

Background: Adult cochlear implant (CI) candidacy is assessed in part by the use of speech perception measures. In the United Kingdom the current cut-off point to fall within the CI candidacy range is a score of less than 50% on the BKB sentences pre... Read More about Preliminary assessment of the feasibility of using AB words to assess candidacy in adults.