All Outputs (82)

A 3D printed drug delivery implant formed from a dynamic supramolecular polyurethane formulation (2020)
Journal Article
Salimi, S., Wu, Y., Barreiros, M. I. E., Natfji, A. A., Khaled, S., Wildman, R., …Hayes, W. (2020). A 3D printed drug delivery implant formed from a dynamic supramolecular polyurethane formulation. Polymer Chemistry, 11(20), 3453-3464. https://doi.org/10.1039/d0py00068j

© 2020 The Royal Society of Chemistry. Using a novel molecular design approach, we have prepared a thermo-responsive supramolecular polyurethane as a matrix material for use in drug eluting implants. The dynamic supramolecular polyurethane (SPU) is a... Read More about A 3D printed drug delivery implant formed from a dynamic supramolecular polyurethane formulation.

Making tablets for delivery of poorly soluble drugs using photoinitiated 3D inkjet printing (2019)
Journal Article
Yoo, J., Clark, E. A., Wallace, M. J., Irvine, D. J., Alexander, M. R., Roberts, C. J., & Wildman, R. D. (2020). Making tablets for delivery of poorly soluble drugs using photoinitiated 3D inkjet printing. International Journal of Pharmaceutics, 578, https://doi.org/10.1016/j.ijpharm.2019.118805

© 2019 In this study, we investigate the viability of three-dimensional (3D) inkjet printing with UV curing to produce solid dosage forms containing a known poorly soluble drug, carvedilol. The formulation consists of 10 wt% carvedilol, Irgacure 2959... Read More about Making tablets for delivery of poorly soluble drugs using photoinitiated 3D inkjet printing.

Design of highly stabilized nanocomposite inks based on biodegradable polymer-matrix and gold nanoparticles for Inkjet Printing (2019)
Journal Article
Begines, B., Alcudia, A., Aguilera-Velazquez, R., Martinez, G., He, Y., Wildman, R., …Prado-Gotor, R. (2019). Design of highly stabilized nanocomposite inks based on biodegradable polymer-matrix and gold nanoparticles for Inkjet Printing. Scientific Reports, 9, Article 16097. https://doi.org/10.1038/s41598-019-52314-2

Nowadays there is a worldwide growing interest in the Inkjet Printing technology owing to its potentially high levels of geometrical complexity, personalization and resolution. There is also social concern about usage, disposal and accumulation of pl... Read More about Design of highly stabilized nanocomposite inks based on biodegradable polymer-matrix and gold nanoparticles for Inkjet Printing.

Towards digital metal additive manufacturing via high-temperature drop-on-demand jetting (2019)
Journal Article
Simonelli, M., Aboulkhair, N., Rasa, M., East, M., Tuck, C., Wildman, R., …Hague, R. (2019). Towards digital metal additive manufacturing via high-temperature drop-on-demand jetting. Additive Manufacturing, 30, Article 100930. https://doi.org/10.1016/j.addma.2019.100930

Drop-on-demand jetting of metals offers a fully digital manufacturing approach to surpass the limitations of the current generation powder-based additive manufacturing technologies. However, research on this topic has been restricted mainly to near-n... Read More about Towards digital metal additive manufacturing via high-temperature drop-on-demand jetting.

Multifunctional Bioinstructive 3D Architectures to Modulate Cellular Behavior (2019)
Journal Article
Vaithilingam, J., Sanjuan‐Alberte, P., Campora, S., Rance, G. A., Jiang, L., Thorpe, J., …Rawson, F. J. (2019). Multifunctional Bioinstructive 3D Architectures to Modulate Cellular Behavior. Advanced Functional Materials, 29(38), Article 1902016. https://doi.org/10.1002/adfm.201902016

Biological structures control cell behavior via physical, chemical, electrical, and mechanical cues. Approaches that allow us to build devices that mimic these cues in a combinatorial way are lacking due to there being no suitable instructive materia... Read More about Multifunctional Bioinstructive 3D Architectures to Modulate Cellular Behavior.

High-throughput characterization of fluid properties to predict droplet ejection for three-dimensional inkjet printing formulations (2019)
Journal Article
Zhou, Z., Ruiz Cantu, L., Chen, X., Alexander, M. R., Roberts, C. J., Hague, R., …Wildman, R. (2019). High-throughput characterization of fluid properties to predict droplet ejection for three-dimensional inkjet printing formulations. Additive Manufacturing, 29, Article 100792. https://doi.org/10.1016/j.addma.2019.100792

Inkjet printing has been used as an Additive Manufacturing (AM) method to fabricate three-dimensional (3D) structures. However, a lack of materials suitable for inkjet printing poses one of the key challenges that impedes industry from fully adopting... Read More about High-throughput characterization of fluid properties to predict droplet ejection for three-dimensional inkjet printing formulations.

Water-Based 3D Inkjet Printing of an Oral Pharmaceutical Dosage Form (2019)
Journal Article
Cader, H. K., Rance, G. A., Alexander, M. R., Gonçalves, A. D., Roberts, C. J., Tuck, C. J., & Wildman, R. D. (2019). Water-Based 3D Inkjet Printing of an Oral Pharmaceutical Dosage Form. International Journal of Pharmaceutics, 564, 359-368. https://doi.org/10.1016/j.ijpharm.2019.04.026

Inkjet printing is a form of additive manufacturing where liquid droplets are selectively deposited onto a substrate followed by solidification. The process provides significant potential advantages for producing solid oral dosage forms or tablets, i... Read More about Water-Based 3D Inkjet Printing of an Oral Pharmaceutical Dosage Form.

Lipids and polymers in pharmaceutical technology: lifelong companions (2019)
Journal Article
Siepmann, J., Faham, A., Clas, S., Boyd, B. J., Jannin, V., Bernkop-Schnürch, A., …Leroux, J. (2019). Lipids and polymers in pharmaceutical technology: lifelong companions. International Journal of Pharmaceutics, 558, 128-142. https://doi.org/10.1016/j.ijpharm.2018.12.080

In pharmaceutical technology, lipids and polymers are considered pillar excipients for the fabrication of most dosage forms, irrespective of the administration route. They play various roles ranging from support vehicles to release rate modifiers, st... Read More about Lipids and polymers in pharmaceutical technology: lifelong companions.

Reactive material jetting of polyimide insulators for complex circuit board design (2018)
Journal Article
Zhang, F., Saleh, E., Vaithilingam, J., Li, Y., Tuck, C., Hague, R., …He, Y. (2019). Reactive material jetting of polyimide insulators for complex circuit board design. Additive Manufacturing, 25, 477-484. https://doi.org/10.1016/j.addma.2018.11.017

Polyimides are a group of high performance thermal stable dielectric materials used in diverse applications. In this article, we synthesized and developed a high-performance polyimide precursor ink for a Material Jetting (MJ) process. The proposed in... Read More about Reactive material jetting of polyimide insulators for complex circuit board design.

Geometrical effects on residual stress in selective laser melting (2018)
Journal Article
Parry, L., Ashcroft, I., & Wildman, R. (2019). Geometrical effects on residual stress in selective laser melting. Additive Manufacturing, 25, 166-175. https://doi.org/10.1016/j.addma.2018.09.026

Selective laser melting is an increasingly attractive technology for the manufacture of complex and low volume / high value metal parts. However, the inevitable residual stresses that are generated can lead to defects or build failure. Due to the com... Read More about Geometrical effects on residual stress in selective laser melting.

Extrusion 3D printing of paracetamol tablets from a single formulation with tunable release profiles through control of tablet geometry (2018)
Journal Article
Khaled, S. A., Alexander, M. R., Irvine, D. J., Wildman, R. D., Wallace, M. J., Sharpe, S., …Roberts, C. J. (2018). Extrusion 3D printing of paracetamol tablets from a single formulation with tunable release profiles through control of tablet geometry. AAPS PharmSciTech, 19(8), 3403–3413. https://doi.org/10.1208/s12249-018-1107-z

An extrusion based 3D printer was used to fabricate paracetamol tablets with different geometries (mesh, ring, and solid) from a single paste-based formulation formed from standard pharmaceutical ingredients. The tablets demonstrate that tunable drug... Read More about Extrusion 3D printing of paracetamol tablets from a single formulation with tunable release profiles through control of tablet geometry.

Optimisation of substrate angles for multi-material and multi-functional inkjet printing (2018)
Journal Article
Vaithilingam, J., Saleh, E., Wildman, R. D., Hague, R. J., & Tuck, C. (2018). Optimisation of substrate angles for multi-material and multi-functional inkjet printing. Scientific Reports, 8, Article 9030. https://doi.org/10.1038/s41598-018-27311-6

Three dimensional inkjet printing of multiple materials for electronics applications are challenging due to the limited material availability, inconsistencies in layer thickness between dissimilar materials and the need to expose the printed tracks o... Read More about Optimisation of substrate angles for multi-material and multi-functional inkjet printing.

Effective design and simulation of surface-based lattice structures featuring volume fraction and cell type grading (2018)
Journal Article
Maskery, I., Aremu, A., Parry, L., Wildman, R., Tuck, C., & Ashcroft, I. (2018). Effective design and simulation of surface-based lattice structures featuring volume fraction and cell type grading. Materials and Design, 155, 220-232. https://doi.org/10.1016/j.matdes.2018.05.058

In this paper we present a numerical investigation into surface-based lattice structures with the aim of facilitating their design for additive manufacturing. We give the surface equations for these structures and show how they can be used to tailor... Read More about Effective design and simulation of surface-based lattice structures featuring volume fraction and cell type grading.

3D-printed components for quantum devices (2018)
Journal Article
Saint, R., Evans, W., Zhou, Y., Barrett, T. J., Fromhold, T., Saleh, E., …Krüger, P. (2018). 3D-printed components for quantum devices. Scientific Reports, 8, https://doi.org/10.1038/s41598-018-26455-9

Recent advances in the preparation, control and measurement of atomic gases have led to new insights into the quantum world and unprecedented metrological sensitivities, e.g. in measuring gravitational forces and magnetic fields. The full potential o... Read More about 3D-printed components for quantum devices.

Effect of surfactant on Pseudomonas aeruginosa colonization of polymer microparticles and flat films (2018)
Journal Article
Hüsler, A., Haas, S., Parry, L., Romero, M., Nisisako, T., Williams, P., …Alexander, M. R. (2018). Effect of surfactant on Pseudomonas aeruginosa colonization of polymer microparticles and flat films. RSC Advances, 8(28), https://doi.org/10.1039/c8ra01491d

Micro- and nanoparticles are of great interest because of their potential for trafficking into the body for applications such as low-fouling coatings on medical devices, drug delivery in pharmaceutics and cell carriers in regenerative medicine strate... Read More about Effect of surfactant on Pseudomonas aeruginosa colonization of polymer microparticles and flat films.

Author Correction: Additive manufacture of complex 3D Au-containing nanocomposites by simultaneous two-photon polymerisation and photoreduction (2018)
Journal Article
Hu, Q., Sun, X., Parmenter, C. D. J., Fay, M. W., Smith, E. F., Rance, G. A., …Wildman, R. (2018). Author Correction: Additive manufacture of complex 3D Au-containing nanocomposites by simultaneous two-photon polymerisation and photoreduction. Scientific Reports, 8(1), Article 3512. https://doi.org/10.1038/s41598-018-21513-8

A correction to this article has been published and is linked from the HTML and PDF versions of this paper. The error has not been fixed in the paper.

Tuneable ionic control of polymeric films for inkjet based 3D printing (2018)
Journal Article
Karjalainen, E., Wales, D. J., Gunasekera, D. H., Dupont, J., Licence, P., Wildman, R. D., & Sans, V. (in press). Tuneable ionic control of polymeric films for inkjet based 3D printing. ACS Sustainable Chemistry and Engineering, https://doi.org/10.1021/acssuschemeng.7b04279

Inkjet printing is a powerful additive manufacturing (AM) technique to generate advanced and complex geometries. However, requirements of low viscosity and surface tension are limiting the range of functional inks available, thus hindering the develo... Read More about Tuneable ionic control of polymeric films for inkjet based 3D printing.

Topology optimization of geometrically nonlinear structures using an evolutionary optimization method (2018)
Journal Article
Abdi, M., Ashcroft, I., & Wildman, R. (in press). Topology optimization of geometrically nonlinear structures using an evolutionary optimization method. Engineering Optimization, https://doi.org/10.1080/0305215X.2017.1418864

Iso-XFEM method is an evolutionary optimization method developed in our previous studies to enable the generation of high resolution topology optimised designs suitable for additive manufacture. Conventional approaches for topology optimization requi... Read More about Topology optimization of geometrically nonlinear structures using an evolutionary optimization method.

3D extrusion printing of high drug loading immediate release paracetamol tablets (2018)
Journal Article
Khaled, S. A., Alexander, M. R., Wildman, R. D., Wallace, M. J., Sharpe, S., Yoo, J., & Roberts, C. J. (2018). 3D extrusion printing of high drug loading immediate release paracetamol tablets. International Journal of Pharmaceutics, 538(1-2), 223-230. https://doi.org/10.1016/j.ijpharm.2018.01.024

The manufacture of immediate release high drug loading paracetamol oral tablets was achieved using an extrusion based 3D printer from a premixed water based paste formulation. The 3D printed tablets demonstrate that a very high drug (paracetamol) loa... Read More about 3D extrusion printing of high drug loading immediate release paracetamol tablets.

Design optimization for an additively manufactured automotive component (2018)
Journal Article
Abdi, M., Ashcroft, I., & Wildman, R. D. (2018). Design optimization for an additively manufactured automotive component. International Journal of Powertrains, 7(1-3), https://doi.org/10.1504/IJPT.2018.090371

The aim of this paper is to investigate the design optimization and additive manufacture of automotive components. A Titanium brake pedal processed through Selective Laser Melting (SLM) is considered as a test case. Different design optimisation tech... Read More about Design optimization for an additively manufactured automotive component.