Lipids and polymers in pharmaceutical technology: lifelong companions

Siepmann, Juergen; Faham, Amina; Clas, Sophie-Dorothée; Boyd, Ben J.; Jannin, Vincent; Bernkop-Schnürch, Andreas; Zhao, Hang; Lecommandoux, Sébastien; Evans, James C.; Allen, Christine; Merkel, Olivia M.; Costabile, Gabriella; Alexander, Morgan R.; Wildman, Ricky D.; Roberts, Clive J.; Leroux, Jean-Christophe

Abstract

In pharmaceutical technology, lipids and polymers are considered pillar excipients for the fabrication of most dosage forms, irrespective of the administration route. They play various roles ranging from support vehicles to release rate modifiers, stabilizers, solubilizers, permeation enhancers and transfection agents. Focusing on selected applications, which were discussed at the Annual Scientific Meeting of the Gattefossé Foundation 2018, this manuscript recapitulates the fundamental roles of these two important classes of excipients, either employed alone or in combination, and provides insight on their functional properties in various types of drug formulations. Emphasis is placed on oral formulations for the administration of active pharmaceutical ingredients with low aqueous solubilities or poor permeation properties. Additionally, this review article covers the use of lipids and polymers in the design of colloidal injectable delivery systems, and as substrates in additive manufacturing technologies for the production of tailor-made dosage forms.

Citation

Siepmann, J., Faham, A., Clas, S.-D., Boyd, B. J., Jannin, V., Bernkop-Schnürch, A., …Leroux, J.-C. (2019). Lipids and polymers in pharmaceutical technology: lifelong companions. International Journal of Pharmaceutics, 558, 128-142. https://doi.org/10.1016/j.ijpharm.2018.12.080

• Journal Article Type: Article
• Acceptance Date: Dec 24, 2018
• Online Publication Date: Jan 9, 2019
• Publication Date: Mar 10, 2019
• Deposit Date: Jun 3, 2019
• Publicly Available Date: Jun 4, 2019
• Journal: International Journal of Pharmaceutics
• Print ISSN: 0378-5173
• Electronic ISSN: 1873-3476
• Publisher: Elsevier
• Peer Reviewed: Peer Reviewed
• Volume: 558
• Pages: 128-142
• DOI: https://doi.org/10.1016/j.ijpharm.2018.12.080
• Keywords: Solid dispersions; Self-emulsifying drug delivery systems; Sustained release; Liposomes; Polymersomes; Peptides; Gene delivery; 3D printing
• Public URL: https://nottingham-repository.worktribe.com/output/1438903
• Publisher URL: https://doi.org/10.1016/j.ijpharm.2018.12.080
• Additional Information: This article is maintained by: Elsevier; Article Title: Lipids and polymers in pharmaceutical technology: Lifelong companions; Journal Title: International Journal of Pharmaceutics; CrossRef DOI link to publisher maintained version: https://doi.org/10.1016/j.ijpharm.2018.12.080; Content Type: article; Copyright: © 2019 The Authors. Published by Elsevier B.V.
• Contract Date: Feb 26, 2019