Refining the definition of HER2-low class in invasive breast cancer

Atallah, Nehal M.; Toss, Michael S.; Green, Andrew R.; Mongan, Nigel P.; Ball, Graham; Rakha, Emad A.

doi:10.1111/his.14780

Cryo-scanning electron microscopy demonstrates that ice morphology is not associated with the post-thaw survival of domestic boar (Sus domesticus) spermatozoa: A comparison of directional and conventional freezing methods (2022)
Journal Article
Gillis, J. D., Holt, W. V., Penfold, L. M., Woad, K. J., Graham, J. K., Watts, J. A., …Yon, L. (2022). Cryo-scanning electron microscopy demonstrates that ice morphology is not associated with the post-thaw survival of domestic boar (Sus domesticus) spermatozoa: A comparison of directional and conventional freezing methods. Cryobiology, 108, 10-18. https://doi.org/10.1016/j.cryobiol.2022.08.006

Directional freezing (in 2 or 10 ml hollow glass tubes) has been reported to improve post-thaw sperm survival parameters compared to conventional methods (in 0.5 ml straws). However, the biophysical properties that increase post-thaw survival are poo... Read More about Cryo-scanning electron microscopy demonstrates that ice morphology is not associated with the post-thaw survival of domestic boar (Sus domesticus) spermatozoa: A comparison of directional and conventional freezing methods.

Hoof lesions in partly housed pasture-based dairy cows (2022)
Journal Article
Browne, N., Hudson, C., Crossley, R., Sugrue, K., Huxley, J., & Conneely, M. (2022). Hoof lesions in partly housed pasture-based dairy cows. Journal of Dairy Science, 105(11), 9038-9053. https://doi.org/10.3168/jds.2022-22010

Lameness is a symptom of a painful disorder affecting the limbs, which impacts dairy cow welfare and productivity. Lameness is primarily caused by hoof lesions. The prevalence of different lesion types can differ depending on environmental conditions... Read More about Hoof lesions in partly housed pasture-based dairy cows.

Dissecting microbial communities and resistomes for interconnected humans, soil, and livestock (2022)
Journal Article
Maciel-Guerra, A., Baker, M., Hu, Y., Wang, W., Zhang, X., Rong, J., …Dottorini, T. (2023). Dissecting microbial communities and resistomes for interconnected humans, soil, and livestock. ISME Journal, 17, 21-35. https://doi.org/10.1038/s41396-022-01315-7

A debate is currently ongoing as to whether intensive livestock farms may constitute reservoirs of clinically relevant antimicrobial resistance (AMR), thus posing a threat to surrounding communities. Here, combining shotgun metagenome sequencing, mac... Read More about Dissecting microbial communities and resistomes for interconnected humans, soil, and livestock.

The role of extracellular vesicle miRNAs and tRNAs in synovial fibroblast senescence (2022)
Journal Article
Wijesinghe, S. N., Anderson, J., Brown, T. J., Nanus, D. E., Housmans, B., Green, J. A., …Peffers, M. J. (2022). The role of extracellular vesicle miRNAs and tRNAs in synovial fibroblast senescence. Frontiers in Molecular Biosciences, 9, Article 971621. https://doi.org/10.3389/fmolb.2022.971621

Extracellular vesicles are mediators of intercellular communication with critical roles in cellular senescence and ageing. In arthritis, senescence is linked to the activation of a pro-inflammatory phenotype contributing to chronic arthritis pathogen... Read More about The role of extracellular vesicle miRNAs and tRNAs in synovial fibroblast senescence.

Microfluidic-Based Formulation of Essential Oils-Loaded Chitosan Coated PLGA Particles Enhances Their Bioavailability and Nematocidal Activity (2022)
Journal Article
Helal, M. A., Abdel-Gawad, A. M., Kandil, O. M., Khalifa, M. M., Morrison, A. A., Bartley, D. J., …Elsheikha, H. M. (2022). Microfluidic-Based Formulation of Essential Oils-Loaded Chitosan Coated PLGA Particles Enhances Their Bioavailability and Nematocidal Activity. Pharmaceutics, 14(10), Article 2030. https://doi.org/10.3390/pharmaceutics14102030

In this study, poly (lactic-co-glycolic) acid (PLGA) particles were synthesized and coated with chitosan. Three essential oil (EO) components (eugenol, linalool, and geraniol) were entrapped inside these PLGA particles by using the continuous flow-fo... Read More about Microfluidic-Based Formulation of Essential Oils-Loaded Chitosan Coated PLGA Particles Enhances Their Bioavailability and Nematocidal Activity.

Trigeminal-mediated headshaking: A diagnostic challenge (2022)
Journal Article
Pickles, K. (2023). Trigeminal-mediated headshaking: A diagnostic challenge. Equine Veterinary Education, 35(4), 195-196. https://doi.org/10.1111/eve.13723

The term 'equine trigeminal-mediated headshaking' (TMHS) has replaced the previously used diagnosis of ‘idiopathic headshaking’ to reflect the clinical signs, which are considered to characterise trigeminal neuropathic pain (Pickles et al., 2014). Th... Read More about Trigeminal-mediated headshaking: A diagnostic challenge.

African Ancestry–Associated Gene Expression Profiles in Triple-Negative Breast Cancer Underlie Altered Tumor Biology and Clinical Outcome in Women of African Descent (2022)
Journal Article
Martini, R., Delpe, P., Chu, T. R., Arora, K., Lord, B., Verma, A., …Davis, M. B. (2022). African Ancestry–Associated Gene Expression Profiles in Triple-Negative Breast Cancer Underlie Altered Tumor Biology and Clinical Outcome in Women of African Descent. Cancer Discovery, 12(11), 2530-2551. https://doi.org/10.1158/2159-8290.CD-22-0138

Women of sub-Saharan African descent have disproportionately higher incidence of triple-negative breast cancer (TNBC) and TNBC-specific mortality across all populations. Population studies show racial differences in TNBC biology, including higher pre... Read More about African Ancestry–Associated Gene Expression Profiles in Triple-Negative Breast Cancer Underlie Altered Tumor Biology and Clinical Outcome in Women of African Descent.

Ki67 assessment in invasive luminal breast cancer: a comparative study between different scoring methods (2022)
Journal Article
Lashen, A., Toss, M. S., Green, A. R., Mongan, N. P., & Rakha, E. (2022). Ki67 assessment in invasive luminal breast cancer: a comparative study between different scoring methods. Histopathology, 81(6), 786-798. https://doi.org/10.1111/his.14781

Background: Ki67 reflects the proliferation activity in breast cancer (BC). However, an optimal method for its assessment in clinical settings has yet to be robustly defined. In this study, we compared several methods to score Ki67 to identify a reli... Read More about Ki67 assessment in invasive luminal breast cancer: a comparative study between different scoring methods.

Antimicrobial resistance in dairy slurry tanks: a critical point for measurement and control (2022)
Journal Article
Baker, M., Williams, A. D., Hooton, S. P., Helliwell, R., King, E., Dodsworth, T., …Stekel, D. J. (2022). Antimicrobial resistance in dairy slurry tanks: a critical point for measurement and control. Environment International, 169, Article 107516. https://doi.org/10.1016/j.envint.2022.107516

Waste from dairy production is one of the largest sources of contamination from antimicrobial resistant bacteria (ARB) and genes (ARGs) in many parts of the world. However, studies to date do not provide necessary evidence to inform antimicrobial res... Read More about Antimicrobial resistance in dairy slurry tanks: a critical point for measurement and control.

Lipidomic changes in the liver of beagle dogs associated with Toxocara canis infection (2022)
Journal Article
Li, H. Y., Zou, Y., Elsheikha, H. M., Xu, Y., Cai, L., Xie, S. C., …Zheng, W. B. (2022). Lipidomic changes in the liver of beagle dogs associated with Toxocara canis infection. Frontiers in Cellular and Infection Microbiology, 12, Article 890589. https://doi.org/10.3389/fcimb.2022.890589

A global lipidomic analysis using liquid chromatography–tandem mass spectrometry was performed on the liver of beagle dogs infected with Toxocara canis to profile hepatic lipid species at 12h post-infection (hpi), 24 hpi, and 36 days post-infection (... Read More about Lipidomic changes in the liver of beagle dogs associated with Toxocara canis infection.

Anatomy, histology, development and functions of Ossa cordis: A review (2022)
Journal Article
Best, A., Egerbacher, M., Swaine, S., Pérez, W., Alibhai, A., Rutland, P., …Rutland, C. S. (2022). Anatomy, histology, development and functions of Ossa cordis: A review. Anatomia, Histologia, Embryologia, 51(6), 683-695. https://doi.org/10.1111/ahe.12861

This systematic review highlights the similarities and variations in Ossa cordis prevalence, histology and anatomical location between differing veterinary species and in humans. In addition, it also identifies associated factors such as aging and ca... Read More about Anatomy, histology, development and functions of Ossa cordis: A review.

Evaluation of Current and Future Diagnostic and Prognostic Techniques for Traumatic Pericarditis in Cattle (2022)
Book Chapter
Hall, J., Barker, E., Best, A., & Rutland, C. S. (2022). Evaluation of Current and Future Diagnostic and Prognostic Techniques for Traumatic Pericarditis in Cattle. In C. Rutland, & S. El-Gendy (Eds.), Updates on Veterinary Anatomy and Physiology. InTech. https://doi.org/10.5772/intechopen.106576

Pericarditis in cattle can be classified as traumatic pericarditis (TP), idiopathic haemorrhagic, secondary to neoplasia or septic pericarditis due to haematogenous spread of organisms, such as Colibacilli or Pasturella. In cattle, pericardial diseas... Read More about Evaluation of Current and Future Diagnostic and Prognostic Techniques for Traumatic Pericarditis in Cattle.

Epidemiology of equine influenza in the Maghreb area (2022)
Journal Article
Kareche, H., Daly, J. M., & Laabassi, F. (2022). Epidemiology of equine influenza in the Maghreb area. Comparative Immunology, Microbiology and Infectious Diseases, 89, Article 101868. https://doi.org/10.1016/j.cimid.2022.101868

Equine influenza (EI) is one of the most contagious respiratory infections in horses, donkeys and mules, caused by equine influenza A virus (EIV). It remains a disease with a strong economic stake for the equine industry. This review focuses on the e... Read More about Epidemiology of equine influenza in the Maghreb area.

Optical photothermal infrared spectroscopy can differentiate equine osteoarthritic plasma extracellular vesicles from healthy controls (2022)
Journal Article
Clarke, E. J., Lima, C., Anderson, J. R., Castanheira, C., Beckett, A., James, V., …Peffers, M. J. (2022). Optical photothermal infrared spectroscopy can differentiate equine osteoarthritic plasma extracellular vesicles from healthy controls. Analytical Methods, 14(37), 3661-3670. https://doi.org/10.1039/d2ay00779g

Equine osteoarthritis is a chronic degenerative disease of the articular joint, characterised by cartilage degradation resulting in pain and reduced mobility and thus is a prominent equine welfare concern. Diagnosis is usually at a late stage through... Read More about Optical photothermal infrared spectroscopy can differentiate equine osteoarthritic plasma extracellular vesicles from healthy controls.

Potential of ESBL-producing Escherichia coli selection in bovine feces after intramammary administration of first generation cephalosporins using in vitro experiments (2022)
Journal Article
Speksnijder, D. C., Hopman, N. E. M., Kusters, N. E., Timmerman, A., Swinkels, J. M., Penterman, P. A. A., …Zomer, A. L. (2022). Potential of ESBL-producing Escherichia coli selection in bovine feces after intramammary administration of first generation cephalosporins using in vitro experiments. Scientific Reports, 12, Article 15083. https://doi.org/10.1038/s41598-022-15558-z

Selection and spread of Extended Spectrum Beta-Lactamase (ESBL) -producing Enterobacteriaceae within animal production systems and potential spillover to humans is a major concern. Intramammary treatment of dairy cows with first-generation cephalospo... Read More about Potential of ESBL-producing Escherichia coli selection in bovine feces after intramammary administration of first generation cephalosporins using in vitro experiments.

Ethnic meat products/Indian subcontinent (2022)
Book Chapter
Bhandare, S., & Gadekar, Y. (2022). Ethnic meat products/Indian subcontinent. In Reference Module in Food Science. Elsevier. https://doi.org/10.1016/b978-0-323-85125-1.00075-2

Ethnic meat products are part of the identity of a local culture, are always popular locally, have evolved over centuries and are passed over from generation to generation. There are several traditional meat products and recipes in the Indian subcont... Read More about Ethnic meat products/Indian subcontinent.

Artificial microvesicles: new perspective on healing tendon wounds (2022)
Journal Article
Zakirova, E., Aimaletdinov, A., Mansurova, M., Titova, A., Kurilov, I., Rutland, C. S., …Rizvanov, A. (2022). Artificial microvesicles: new perspective on healing tendon wounds. Cells Tissues Organs, https://doi.org/10.1159/000526845

Tendons have a limited capacity to repair both naturally and following clinical interventions. Damaged tissue often presents with structural and functional differences, adversely affecting animal performance, mobility, health and welfare. Advances in... Read More about Artificial microvesicles: new perspective on healing tendon wounds.

Effect of tuberculin skin testing on serological results against Mycobacterium avium ssp. paratuberculosis (MAP): Evidence of distinct effects in MAP-infected and noninfected cows (2022)
Journal Article
Nunney, E., Crotta, M., van Winden, S., Bond, K., Green, M., & Guitian, J. (2022). Effect of tuberculin skin testing on serological results against Mycobacterium avium ssp. paratuberculosis (MAP): Evidence of distinct effects in MAP-infected and noninfected cows. Journal of Dairy Science, 105(10), 8354-8363. https://doi.org/10.3168/jds.2021-21753

Johne's disease and bovine tuberculosis are diseases of economic, public health, and animal welfare importance. The single intradermal cervical comparative tuberculin (SICCT) test, which is used to determine bovine tuberculosis status as part of erad... Read More about Effect of tuberculin skin testing on serological results against Mycobacterium avium ssp. paratuberculosis (MAP): Evidence of distinct effects in MAP-infected and noninfected cows.

Refining the definition of HER2-low class in invasive breast cancer (2022)
Journal Article
Atallah, N. M., Toss, M. S., Green, A. R., Mongan, N. P., Ball, G., & Rakha, E. A. (2022). Refining the definition of HER2-low class in invasive breast cancer. Histopathology, 81(6), 770-785. https://doi.org/10.1111/his.14780

Background: Emerging evidence indicates that breast cancer (BC) patients whose tumours express HER2 protein without HER2 gene amplification (HER2-low), can benefit from antibody–drug conjugates (ADC). However, the current definition of HER2-low BC re... Read More about Refining the definition of HER2-low class in invasive breast cancer.

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