All Outputs (125)

Mass spectrometry and machine learning for the accurate diagnosis of benzylpenicillin and multidrug resistance of Staphylococcus aureus in bovine mastitis (2021)
Journal Article
Esener, N., Guerra, A. M., Giebel, K., Lea, D., Green, M. J., Bradley, A. J., & Dottorini, T. (2021). Mass spectrometry and machine learning for the accurate diagnosis of benzylpenicillin and multidrug resistance of Staphylococcus aureus in bovine mastitis. PLoS Computational Biology, 17(6), Article e1009108. https://doi.org/10.1371/journal.pcbi.1009108

Staphylococcus aureus is a serious human and animal pathogen threat exhibiting extraordinary capacity for acquiring new antibiotic resistance traits in the pathogen population worldwide. The development of fast, affordable and effective diagnostic... Read More about Mass spectrometry and machine learning for the accurate diagnosis of benzylpenicillin and multidrug resistance of Staphylococcus aureus in bovine mastitis.

BSE can propagate in sheep co-infected or pre-infected with scrapie (2021)
Journal Article
Chong, A., Foster, J. D., Goldmann, W., Gonzalez, L., Jeffrey, M., O'Connor, M. J., …Hunter, N. (2021). BSE can propagate in sheep co-infected or pre-infected with scrapie. Scientific Reports, 11, Article 11931. https://doi.org/10.1038/s41598-021-91397-8

To understand the possible role of mixed-prion infections in disease presentation, the current study reports the co-infection of sheep with bovine spongiform encephalopathy (BSE) and scrapie. The bovine BSE agent was inoculated subcutaneously into sh... Read More about BSE can propagate in sheep co-infected or pre-infected with scrapie.

LINE-1 transcription in round spermatids is associated with accretion of 5-carboxylcytosine in their open reading frames (2021)
Journal Article
Blythe, M. J., Kocer, A., Rubio-Roldan, A., Giles, T., Abakir, A., Ialy-Radio, C., …Ruzov, A. (2021). LINE-1 transcription in round spermatids is associated with accretion of 5-carboxylcytosine in their open reading frames. Communications Biology, 4, Article 691. https://doi.org/10.1038/s42003-021-02217-8

Chromatin of male and female gametes undergoes a number of reprogramming events during the transition from germ cell to embryonic developmental programs. Although the rearrangement of DNA methylation patterns occurring in the zygote has been extensiv... Read More about LINE-1 transcription in round spermatids is associated with accretion of 5-carboxylcytosine in their open reading frames.

Practical data skills for the farm animal vet (2021)
Journal Article
Hyde, R., Green, M., Hudson, C., & Remnant, J. (2021). Practical data skills for the farm animal vet. In Practice, 43(5), 257-268. https://doi.org/10.1002/inpr.53

Background: While farm animal veterinarians receive extensive training in the diagnosis and treatment of individual animals, population medicine or ‘herd health’ has also become commonplace in modern production animal veterinary medicine. Clinicians... Read More about Practical data skills for the farm animal vet.

Biology, epidemiology, clinical features, diagnosis, and treatment of selected fish-borne parasitic zoonoses (2021)
Journal Article
Cong, W., & Elsheikha, H. M. (2021). Biology, epidemiology, clinical features, diagnosis, and treatment of selected fish-borne parasitic zoonoses. Yale Journal of Biology and Medicine, 94(2), 297-309

Fish-borne parasites have been part of the global landscape of food-borne zoonotic diseases for many decades and are often endemic in certain regions of the world. The past 20 years or so have seen the expansion of the range of fish-borne parasitic z... Read More about Biology, epidemiology, clinical features, diagnosis, and treatment of selected fish-borne parasitic zoonoses.

The dysregulated Pink1- drosophila mitochondrial proteome is partially corrected with exercise (2021)
Journal Article
Ebanks, B., Ingram, T. L., Katyal, G., Ingram, J. R., Moisoi, N., & Chakrabarti, L. (2021). The dysregulated Pink1- drosophila mitochondrial proteome is partially corrected with exercise. Aging, 13(11), 14709-14728. https://doi.org/10.18632/aging.203128

One of the genes which has been linked to the onset of juvenile/early onset Parkinson’s disease (PD) is PINK1. There is evidence that supports the therapeutic potential of exercise in the alleviation of PD symptoms. It is possible that exercise may e... Read More about The dysregulated Pink1- drosophila mitochondrial proteome is partially corrected with exercise.

Multiple model triangulation to identify factors associated with lameness in British sheep flocks (2021)
Journal Article
Lewis, K., Green, M., Witt, J., & Green, L. (2021). Multiple model triangulation to identify factors associated with lameness in British sheep flocks. Preventive Veterinary Medicine, 193, Article 105395. https://doi.org/10.1016/j.prevetmed.2021.105395

Identification of factors associated with an outcome can be challenging when the number of explanatory variables is large in relation to the number of observations. Multiple model triangulation, where results from several model types are combined, im... Read More about Multiple model triangulation to identify factors associated with lameness in British sheep flocks.

Proangiogenic Effect of 2A-Peptide Based Multicistronic Recombinant Constructs Encoding VEGF and FGF2 Growth Factors (2021)
Journal Article
Gatina, D. Z., Garanina, E. E., Zhuravleva, M. N., Synbulatova, G. E., Mullakhmetova, A. F., Solovyeva, V. V., …Salafutdinov, I. I. (2021). Proangiogenic Effect of 2A-Peptide Based Multicistronic Recombinant Constructs Encoding VEGF and FGF2 Growth Factors. International Journal of Molecular Sciences, 22(11), Article 5922. https://doi.org/10.3390/ijms22115922

Coronary artery disease remains one of the primary healthcare problems due to the high cost of treatment, increased number of patients, poor clinical outcomes, and lack of effective therapy. Though pharmacological and surgical treatments positively a... Read More about Proangiogenic Effect of 2A-Peptide Based Multicistronic Recombinant Constructs Encoding VEGF and FGF2 Growth Factors.

Bacterial Infective Stifle Arthritis Secondary to a Migrating Grass Seed Foreign Body in an Adult Dog (2021)
Journal Article
Prior, S., & Arthurs, G. (2021). Bacterial Infective Stifle Arthritis Secondary to a Migrating Grass Seed Foreign Body in an Adult Dog. Vet Record Case Reports, 9(3), Article e88. https://doi.org/10.1002/vrc2.88

An adult neutered male cocker spaniel was presented with a 2-3week history of left pelvic limb lameness, stifle effusion, general malaise and pyrexia. Computed tomography (CT) imaging revealed an irregular tubular tract, extending from the stifle d... Read More about Bacterial Infective Stifle Arthritis Secondary to a Migrating Grass Seed Foreign Body in an Adult Dog.

Trace element composition of tree fodder and potential nutritional use for livestock (2021)
Journal Article
Kendall, N., Smith, J., Whistance, L., Stergiadis, S., Stoate, C., Chesshire, H., & Smith, A. (2021). Trace element composition of tree fodder and potential nutritional use for livestock. Livestock Science, 250, Article 104560. https://doi.org/10.1016/j.livsci.2021.104560

Silvopastoral agroforestry, the integration of trees into livestock production systems, is an ancient practice with benefits to animal welfare and nutrition. Intensification of farming practices have reduced the presence of trees and hedgerows in th... Read More about Trace element composition of tree fodder and potential nutritional use for livestock.

Transforming growth factor-β1 disrupts angiogenesis during the follicular–luteal transition through the Smad–serpin family E member 1 (SERPINE1)/serpin family B member 5 (SERPINB5) signalling pathway in the cow (2021)
Journal Article
Yan, L., Qu, X., Yu, J., Robinson, B., Woad, K., & Shi, Z. (2021). Transforming growth factor-β1 disrupts angiogenesis during the follicular–luteal transition through the Smad–serpin family E member 1 (SERPINE1)/serpin family B member 5 (SERPINB5) signalling pathway in the cow. Reproduction, Fertility and Development, 33(10), 643-654. https://doi.org/10.1071/RD20325

Intense angiogenesis is critical for the development of the corpus luteum and is tightly regulated by numerous factors. However, the exact role transforming growth factor beta 1 (TGFB1) plays during this follicular-luteal transition remains unclear.... Read More about Transforming growth factor-β1 disrupts angiogenesis during the follicular–luteal transition through the Smad–serpin family E member 1 (SERPINE1)/serpin family B member 5 (SERPINB5) signalling pathway in the cow.

The Role of Extracellular Vesicles in the Development of a Cancer Stem Cell Microenvironment Niche and Potential Therapeutic Targets: a systematic review (2021)
Journal Article
Brown, T. J., & James, V. (2021). The Role of Extracellular Vesicles in the Development of a Cancer Stem Cell Microenvironment Niche and Potential Therapeutic Targets: a systematic review. Cancers, 13(10), Article 2435. https://doi.org/10.3390/cancers13102435

Cancer stem cells (CSCs) have increasingly been shown to be a crucial element of heterogenous tumors. Although a relatively small component of the population, they increase the resistance to treatment and the likelihood of recurrence. In recent years... Read More about The Role of Extracellular Vesicles in the Development of a Cancer Stem Cell Microenvironment Niche and Potential Therapeutic Targets: a systematic review.

Comparative Genomic Analysis of the Foodborne Pathogen Burkholderia gladioli pv. cocovenenans Harboring a Bongkrekic Acid Biosynthesis Gene Cluster (2021)
Journal Article
Peng, Z., Dottorini, T., Hu, Y., Li, M., Yan, S., Fanning, S., …Li, F. (2021). Comparative Genomic Analysis of the Foodborne Pathogen Burkholderia gladioli pv. cocovenenans Harboring a Bongkrekic Acid Biosynthesis Gene Cluster. Frontiers in Microbiology, 12, Article 628538. https://doi.org/10.3389/fmicb.2021.628538

The environmental bacterium Burkholderia gladioli pv. cocovenenans (B. cocovenenans) has been linked to fatal food poisoning cases in Asia and Africa. Bongkrekic acid (BA), a mitochondrial toxin produced by B. cocovenenans, is thought to be responsib... Read More about Comparative Genomic Analysis of the Foodborne Pathogen Burkholderia gladioli pv. cocovenenans Harboring a Bongkrekic Acid Biosynthesis Gene Cluster.

An Early Block in the Replication of the Atypical Bluetongue Virus Serotype 26 in Culicoides Cells Is Determined by Its Capsid Proteins (2021)
Journal Article
Guimerà Busquets, M., Pullinger, G. D., Darpel, K. E., Cooke, L., Armstrong, S., Simpson, J., …Mertens, P. P. C. (2021). An Early Block in the Replication of the Atypical Bluetongue Virus Serotype 26 in Culicoides Cells Is Determined by Its Capsid Proteins. Viruses, 13(5), Article 919. https://doi.org/10.3390/v13050919

Arboviruses such as bluetongue virus (BTV) replicate in arthropod vectors involved in their transmission between susceptible vertebrate-hosts. The “classical” BTV strains infect and replicate effectively in cells of their insect-vectors (Culicoides b... Read More about An Early Block in the Replication of the Atypical Bluetongue Virus Serotype 26 in Culicoides Cells Is Determined by Its Capsid Proteins.

IFI16 directly senses viral RNA and enhances RIG-I transcription and activation to restrict influenza virus infection (2021)
Journal Article
Jiang, Z., Wei, F., Zhang, Y., Wang, T., Gao, W., Yu, S., …Liu, J. (2021). IFI16 directly senses viral RNA and enhances RIG-I transcription and activation to restrict influenza virus infection. Nature Microbiology, 6, 932–945. https://doi.org/10.1038/s41564-021-00907-x

The retinoic acid-inducible gene I (RIG-I) receptor senses cytoplasmic viral RNA and activates type I interferons (IFN-I) and downstream antiviral immune responses. How RIG-I binds to viral RNA and how its activation is regulated remains unclear. Her... Read More about IFI16 directly senses viral RNA and enhances RIG-I transcription and activation to restrict influenza virus infection.

Histological and immunohistochemical investigation of canine prostate carcinoma with identification of common intraductal carcinoma component (2021)
Journal Article
Brot, S., Lothion?Roy, J., Grau?Roma, L., White, E., Guscetti, F., Rubin, M. A., & Mongan, N. P. (2022). Histological and immunohistochemical investigation of canine prostate carcinoma with identification of common intraductal carcinoma component. Veterinary and Comparative Oncology, 20(1), 38-49. https://doi.org/10.1111/vco.12704

A limited number of species, including men and dogs, spontaneously develop prostate cancer (PC). The histological and molecular relevance of canine PC as a model for the disease in men remains controversial. To address this challenge, this study aime... Read More about Histological and immunohistochemical investigation of canine prostate carcinoma with identification of common intraductal carcinoma component.

Quality Improvement: origins, purpose and the future for veterinary practice (2021)
Journal Article
Rooke, F., Burford, J., Freeman, S., Mair, T., Suthers, J., & Brennan, M. (2021). Quality Improvement: origins, purpose and the future for veterinary practice. Veterinary Evidence, 6(2), https://doi.org/10.18849/ve.v6i2.358

Providing the highest quality veterinary care can often be a delicate balancing act: the client/owner’s wishes, financial parameters and emotional needs have to be considered, whilst also meeting the animal’s clinical needs. But what actually defines... Read More about Quality Improvement: origins, purpose and the future for veterinary practice.

Diagnosis, Prognosis, Management, Treatment, Research and Advances in Canine Dilated Cardiomyopathy (2021)
Book Chapter
Simpson, S., Kordtomeikel, K., Wong, S., Bennison, S., El-Gendy, S. A., Cobb, M., & Rutland, C. S. (2021). Diagnosis, Prognosis, Management, Treatment, Research and Advances in Canine Dilated Cardiomyopathy. In C. Rutland (Ed.), Canine Medicine : Recent Topics and Advanced Research (1-22). InTech. https://doi.org/10.5772/intechopen.97682

Dilated cardiomyopathy involves enlargement of the ventricular chamber and systolic dysfunction. The reduction in quality of life and increased levels of congestive heart failure, combined with the high diagnosis rate within the canine population, hi... Read More about Diagnosis, Prognosis, Management, Treatment, Research and Advances in Canine Dilated Cardiomyopathy.

An online survey of equestrian headcollar use and safety (2021)
Journal Article
Marlin, D. J., Williams, J. M., & Pickles, K. J. (2021). An online survey of equestrian headcollar use and safety. Equine Veterinary Education, https://doi.org/10.1111/eve.13480

Background Headcollars (halters, US) are one of the most commonly used pieces of equestrian ‘tack’. Despite this, there appears to be minimal information on their use, or more importantly, risk factors for injury of horses/handlers. Objective To... Read More about An online survey of equestrian headcollar use and safety.

From the other perspective: Behavioural factors associated with UK sheep farmers’ attitudes towards antibiotic use and antibiotic resistance (2021)
Journal Article
Doidge, C., Lima, E., Lovatt, F., Hudson, C., & Kaler, J. (2021). From the other perspective: Behavioural factors associated with UK sheep farmers’ attitudes towards antibiotic use and antibiotic resistance. PLoS ONE, 16(5), Article e0251439. https://doi.org/10.1371/journal.pone.0251439

Research suggests that many sheep farmers continue to carry out traditional antibiotic use practices despite new’good practice’ recommendations. The aim of this study was to group farmers depending on their attitudes around antibiotic use and antibio... Read More about From the other perspective: Behavioural factors associated with UK sheep farmers’ attitudes towards antibiotic use and antibiotic resistance.