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The dysregulated Pink1- drosophila mitochondrial proteome is partially corrected with exercise

Ebanks, Brad; Ingram, Thomas L.; Katyal, Gunjan; Ingram, John R.; Moisoi, Nicoleta; Chakrabarti, Lisa

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Authors

Brad Ebanks

Thomas L. Ingram

Gunjan Katyal

John R. Ingram

Nicoleta Moisoi

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LISA CHAKRABARTI LISA.CHAKRABARTI@NOTTINGHAM.AC.UK
Professor of Mitochondrial Biology



Abstract

One of the genes which has been linked to the onset of juvenile/early onset Parkinson’s disease (PD) is PINK1. There is evidence that supports the therapeutic potential of exercise in the alleviation of PD symptoms. It is possible that exercise may enhance synaptic plasticity, protect against neuro-inflammation and modulate L-Dopa regulated signalling pathways. We explored the effects of exercise on Pink1 deficient Drosophila melanogaster which undergo neurodegeneration and muscle degeneration. We used a ‘power-tower’ type exercise platform to deliver exercise activity to Pink1- and age matched wild-type Drosophila. Mitochondrial proteomic profiles responding to exercise were obtained. Of the 516 proteins identified, 105 proteins had different levels between Pink1- and wild-type non-exercised Drosophila. Gene ontology enrichment analysis and STRING network analysis highlighted proteins and pathways with altered expression within the mitochondrial proteome. Comparison of the Pink1- exercised proteome to wild-type proteomes showed that exercising the Pink1- Drosophila caused their proteomic profile to return towards wild-type levels.

Citation

Ebanks, B., Ingram, T. L., Katyal, G., Ingram, J. R., Moisoi, N., & Chakrabarti, L. (2021). The dysregulated Pink1- drosophila mitochondrial proteome is partially corrected with exercise. Aging, 13(11), 14709-14728. https://doi.org/10.18632/aging.203128

Journal Article Type Article
Acceptance Date May 20, 2021
Online Publication Date Jun 1, 2021
Publication Date Jun 15, 2021
Deposit Date Jun 3, 2021
Publicly Available Date Mar 29, 2024
Journal Aging
Publisher Impact Journals, LLC
Peer Reviewed Peer Reviewed
Volume 13
Issue 11
Pages 14709-14728
DOI https://doi.org/10.18632/aging.203128
Public URL https://nottingham-repository.worktribe.com/output/5623816
Publisher URL https://www.aging-us.com/article/203128/text

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