All Outputs (2275)

Optimization of Peptide Linker-Based Fluorescent Ligands for the Histamine H1 Receptor (2022)
Journal Article
Kok, Z. Y., Stoddart, L. A., Mistry, S. J., Mocking, T. A., Vischer, H. F., Leurs, R., …Kellam, B. (2022). Optimization of Peptide Linker-Based Fluorescent Ligands for the Histamine H1 Receptor. Journal of Medicinal Chemistry, 65(12), 8258–8288. https://doi.org/10.1021/acs.jmedchem.2c00125

The histamine H1 receptor (H1R) has recently been implicated in mediating cell proliferation and cancer progression, therefore high affinity H1R-selective fluorescent ligands are desirable tools for further investigation of this behaviour in vitro an... Read More about Optimization of Peptide Linker-Based Fluorescent Ligands for the Histamine H1 Receptor.

Symbiopectobacterium purcellii, gen. nov., sp. nov., isolated from the leafhopper Empoasca decipiens (2022)
Journal Article
Nadal-Jimenez, P., Siozios, S., Halliday, N., Cámara, M., & Hurst, G. D. D. (2022). Symbiopectobacterium purcellii, gen. nov., sp. nov., isolated from the leafhopper Empoasca decipiens. International Journal of Systematic and Evolutionary Microbiology, 72(6), Article 005440. https://doi.org/10.1099/ijsem.0.005440

Bacterial endosymbionts are found in multiple arthropod species, where they play crucial roles as nutritional symbionts, defensive symbionts or reproductive parasites. Recent work has highlighted a new clade of heritable microbes within the gammaprot... Read More about Symbiopectobacterium purcellii, gen. nov., sp. nov., isolated from the leafhopper Empoasca decipiens.

Energy Metabolism in Mouse Sciatic Nerve A Fibres during Increased Energy Demand (2022)
Journal Article
Rich, L. R., Ransom, B. R., & Brown, A. M. (2022). Energy Metabolism in Mouse Sciatic Nerve A Fibres during Increased Energy Demand. Metabolites, 12(6), Article 505. https://doi.org/10.3390/metabo12060505

The ability of sciatic nerve A fibres to conduct action potentials relies on an adequate supply of energy substrate, usually glucose, to maintain necessary ion gradients. Under our ex vivo experimental conditions, the absence of exogenously applied g... Read More about Energy Metabolism in Mouse Sciatic Nerve A Fibres during Increased Energy Demand.

Involvement of β-adrenoceptors in the cardiovascular responses induced by selective adenosine A2A and A2B receptor agonists (2022)
Journal Article
Wragg, E. S., Pannucci, P., Hill, S. J., Woolard, J., & Cooper, S. L. (2022). Involvement of β-adrenoceptors in the cardiovascular responses induced by selective adenosine A2A and A2B receptor agonists. Pharmacology Research and Perspectives, 10(3), Article e00975. https://doi.org/10.1002/prp2.975

A2A and A2B adenosine receptors produce regionally selective regulation of vascular tone and elicit differing effects on mean arterial pressure (MAP), whilst inducing tachycardia. The tachycardia induced by the stimulation of A2A or A2B receptors has... Read More about Involvement of β-adrenoceptors in the cardiovascular responses induced by selective adenosine A2A and A2B receptor agonists.

Are polymorphisms affecting serum urate, renal urate handling and alcohol intake associated with co-morbidities in gout cases? A case–control study using data from the UK Biobank (2022)
Journal Article
Sandoval-Plata, G., Morgan, K., & Abhishek, A. (2022). Are polymorphisms affecting serum urate, renal urate handling and alcohol intake associated with co-morbidities in gout cases? A case–control study using data from the UK Biobank. Rheumatology International, 42, 1617-1622. https://doi.org/10.1007/s00296-022-05148-7

Objective: To examine the association between common comorbidities, eGFR and loci involved in the hyperuricaemia-gout transition. Methods: This study was conducted in people with gout from the UK Biobank. Logistic regression was used to examine th... Read More about Are polymorphisms affecting serum urate, renal urate handling and alcohol intake associated with co-morbidities in gout cases? A case–control study using data from the UK Biobank.

Prognostic non-invasive biomarkers for all-cause mortality in non-alcoholic fatty liver disease: A systematic review and meta-analysis (2022)
Journal Article
Cianci, N., Subhani, M., Hill, T., Khanna, A., Zheng, D., Sheth, A., …Aithal, G. P. (2022). Prognostic non-invasive biomarkers for all-cause mortality in non-alcoholic fatty liver disease: A systematic review and meta-analysis. World Journal of Hepatology, 14(5), 1025-1037. https://doi.org/10.4254/wjh.v14.i5.1025

BACKGROUND Non-alcoholic fatty liver disease (NAFLD) represents a growing public health concern, with patients having higher risk of morbidity and mortality. It has a considerably high prevalence in the general population, estimated 20%-40% in Europe... Read More about Prognostic non-invasive biomarkers for all-cause mortality in non-alcoholic fatty liver disease: A systematic review and meta-analysis.

Production of 3′,3′-cGAMP by a Bdellovibrio bacteriovorus promiscuous GGDEF enzyme, Bd0367, regulates exit from prey by gliding motility (2022)
Journal Article
Lowry, R. C., Hallberg, Z. F., Till, R., Simons, T. J., Nottingham, R., Want, F., …Lambert, C. (2022). Production of 3′,3′-cGAMP by a Bdellovibrio bacteriovorus promiscuous GGDEF enzyme, Bd0367, regulates exit from prey by gliding motility. PLoS Genetics, 18(5), Article e1010164. https://doi.org/10.1371/journal.pgen.1010164

Bacterial second messengers are important for regulating diverse bacterial lifestyles. Cyclic di-GMP (c-di-GMP) is produced by diguanylate cyclase enzymes, named GGDEF proteins, which are widespread across bacteria. Recently, hybrid promiscuous (Hypr... Read More about Production of 3′,3′-cGAMP by a Bdellovibrio bacteriovorus promiscuous GGDEF enzyme, Bd0367, regulates exit from prey by gliding motility.

Economic significance of biofilms: a multidisciplinary and cross-sectoral challenge (2022)
Journal Article
Cámara, M., Green, W., MacPhee, C. E., Rakowska, P. D., Raval, R., Richardson, M. C., …Webb, J. S. (2022). Economic significance of biofilms: a multidisciplinary and cross-sectoral challenge. npj Biofilms and Microbiomes, 8(1), Article 42. https://doi.org/10.1038/s41522-022-00306-y

The increasing awareness of the significance of microbial biofilms across different sectors is continuously revealing new areas of opportunity in the development of innovative technologies in translational research, which can address their detrimenta... Read More about Economic significance of biofilms: a multidisciplinary and cross-sectoral challenge.

Age- and sex-specific effects of a long-term lifestyle intervention on body weight and cardiometabolic health markers in adults with prediabetes: results from the diabetes prevention study PREVIEW (2022)
Journal Article
Zhu, R., Craciun, I., Bernhards-Werge, J., Jalo, E., Poppitt, S. D., Silvestre, M. P., …Raben, A. (2022). Age- and sex-specific effects of a long-term lifestyle intervention on body weight and cardiometabolic health markers in adults with prediabetes: results from the diabetes prevention study PREVIEW. Diabetologia, 65(8), 1262-1277. https://doi.org/10.1007/s00125-022-05716-3

Aims/hypothesis Lifestyle interventions are the first-line treatment option for body weight and cardiometabolic health management. However, whether age groups or women and men respond differently to lifestyle interventions is under debate. We aime... Read More about Age- and sex-specific effects of a long-term lifestyle intervention on body weight and cardiometabolic health markers in adults with prediabetes: results from the diabetes prevention study PREVIEW.

Basement membrane properties and their recapitulation in organ-on-chip applications (2022)
Journal Article
Salimbeigi, G., Vrana, N. E., Ghaemmaghami, A. M., Huri, P. Y., & McGuinness, G. B. (2022). Basement membrane properties and their recapitulation in organ-on-chip applications. Materials Today Bio, 15, Article 100301. https://doi.org/10.1016/j.mtbio.2022.100301

Drug discovery and toxicology is a complex process that involves considerable basic research and preclinical evaluation. These depend highly on animal testing which often fails to predict human trial outcomes due to species differences. Coupled with... Read More about Basement membrane properties and their recapitulation in organ-on-chip applications.

Towards Development of a Non-Toxigenic Clostridioides difficile Oral Spore Vaccine against Toxigenic C. difficile (2022)
Journal Article
Hughes, J., Aston, C., Kelly, M. L., & Griffin, R. (2022). Towards Development of a Non-Toxigenic Clostridioides difficile Oral Spore Vaccine against Toxigenic C. difficile. Pharmaceutics, 14(5), Article 1086. https://doi.org/10.3390/pharmaceutics14051086

Clostridioides difficile is an opportunistic gut pathogen which causes severe colitis, leading to significant morbidity and mortality due to its toxins, TcdA and TcdB. Two intra-muscular toxoid vaccines entered Phase III trials and strongly induced t... Read More about Towards Development of a Non-Toxigenic Clostridioides difficile Oral Spore Vaccine against Toxigenic C. difficile.

The changing vaccine landscape: rates of COVID-19 vaccine acceptance and hesitancy in young adults during vaccine rollout (2022)
Journal Article
Knight, H., Jia, R., Ayling, K., Blake, H., Morling, J. R., Villalon, A. M., …Vedhara, K. (2023). The changing vaccine landscape: rates of COVID-19 vaccine acceptance and hesitancy in young adults during vaccine rollout. Perspectives in Public Health, 143(4), 220-224. https://doi.org/10.1177/17579139221094750

Aims: Development and rollout of vaccines offers the best opportunity for population protection against the SARS-CoV-2 (COVID-19) virus. However, hesitancy towards the vaccines might impede successful uptake in the United Kingdom, particularly in you... Read More about The changing vaccine landscape: rates of COVID-19 vaccine acceptance and hesitancy in young adults during vaccine rollout.

Experimental Investigation of a MopFan-Based Photocatalytic Air Purification Device (2022)
Journal Article
Tapia-Brito, E., Riffat, J., Wang, Y., Ghaemmaghami, A. M., Coleman, C. M., & Riffat, S. (2022). Experimental Investigation of a MopFan-Based Photocatalytic Air Purification Device. Future Cities and Environment, 8(1), https://doi.org/10.5334/fce.149

Photocatalytic oxidation (PCO) is a potential approach for air cleaning, especially when utilising titanium dioxide (TiO2). A MopFan is similar to a roller brush but is made of flexible fibres coated with TiO2. Unlike conventional filter/mesh UV syst... Read More about Experimental Investigation of a MopFan-Based Photocatalytic Air Purification Device.

Plasmodium SAS4: basal body component of male cell which is dispensable for parasite transmission (2022)
Journal Article
Zeeshan, M., Brady, D., Markus, R., Vaughan, S., Ferguson, D., Holder, A. A., & Tewari, R. (2022). Plasmodium SAS4: basal body component of male cell which is dispensable for parasite transmission. Life Science Alliance, 5(9), Article e202101329. https://doi.org/10.26508/lsa.202101329

The centriole/basal body (CBB) is an evolutionarily conserved organelle acting as a microtubule organising centre (MTOC) to nucleate cilia, flagella, and the centrosome. SAS4/CPAP is a conserved component associated with BB biogenesis in many model f... Read More about Plasmodium SAS4: basal body component of male cell which is dispensable for parasite transmission.

The Use and Effectiveness of Selected Alternative Markers for Insulin Sensitivity and Secretion Compared with Gold Standard Markers in Dietary Intervention Studies in Individuals without Diabetes: Results of a Systematic Review (2022)
Journal Article
Vazquez Rocha, L., Macdonald, I., Alssema, M., & Færch, K. (2022). The Use and Effectiveness of Selected Alternative Markers for Insulin Sensitivity and Secretion Compared with Gold Standard Markers in Dietary Intervention Studies in Individuals without Diabetes: Results of a Systematic Review. Nutrients, 14(10), Article 2036. https://doi.org/10.3390/nu14102036

Background: The gold‐standard techniques for measuring insulin sensitivity and secretion are well established. However, they may be perceived as invasive and expensive for use in dietary intervention studies. Thus, surrogate markers have been propose... Read More about The Use and Effectiveness of Selected Alternative Markers for Insulin Sensitivity and Secretion Compared with Gold Standard Markers in Dietary Intervention Studies in Individuals without Diabetes: Results of a Systematic Review.

Melanoma-specific antigen-associated antitumor antibody reactivity as an immune-related biomarker for targeted immunotherapies (2022)
Journal Article
Rähni, A., Jaago, M., Sadam, H., Pupina, N., Pihlak, A., Tuvikene, J., …Palm, K. (2022). Melanoma-specific antigen-associated antitumor antibody reactivity as an immune-related biomarker for targeted immunotherapies. Communications Medicine, 2(1), Article 48. https://doi.org/10.1038/s43856-022-00114-7

Background: Immunotherapies, including cancer vaccines and immune checkpoint inhibitors have transformed the management of many cancers. However, a large number of patients show resistance to these immunotherapies and current research has provided l... Read More about Melanoma-specific antigen-associated antitumor antibody reactivity as an immune-related biomarker for targeted immunotherapies.

Enterovirus D68 epidemic, UK, 2018, was caused by subclades B3 and D1, predominantly in children and adults, respectively, with both subclades exhibiting extensive genetic diversity (2022)
Journal Article
Howson-Wells, H. C., Tsoleridis, T., Zainuddin, I., Tarr, A. W., Irving, W. L., Ball, J. K., …McClure, C. P. (2022). Enterovirus D68 epidemic, UK, 2018, was caused by subclades B3 and D1, predominantly in children and adults, respectively, with both subclades exhibiting extensive genetic diversity. Microbial Genomics, 8(5), https://doi.org/10.1099/mgen.0.000825

Enterovirus D68 (EV-D68) has recently been identified in biennial epidemics coinciding with diagnoses of non-polio acute flaccid paralysis/myelitis (AFP/AFM). We investigated the prevalence, genetic relatedness and associated clinical features of EV-... Read More about Enterovirus D68 epidemic, UK, 2018, was caused by subclades B3 and D1, predominantly in children and adults, respectively, with both subclades exhibiting extensive genetic diversity.

Kv3.3 subunits control presynaptic action potential waveform and neurotransmitter release at a central excitatory synapse (2022)
Journal Article
Richardson, A., Ciampani, V., Stancu, M., Bondarenko, K., Newton, S., Steinert, J. R., …Forsythe, I. D. (2022). Kv3.3 subunits control presynaptic action potential waveform and neurotransmitter release at a central excitatory synapse. eLife, 11, Article e75219. https://doi.org/10.7554/eLife.75219

Kv3 potassium currents mediate rapid repolarisation of action potentials (APs), supporting fast spikes and high repetition rates. Of the four Kv3 gene family members, Kv3.1 and Kv3.3 are highly expressed in the auditory brainstem and we exploited thi... Read More about Kv3.3 subunits control presynaptic action potential waveform and neurotransmitter release at a central excitatory synapse.

The effect of agri-environment schemes on Bombus terrestris colony success (2022)
Journal Article
Crowther, L. I., Reader, T., & Gilbert, F. (2022). The effect of agri-environment schemes on Bombus terrestris colony success. Ecological Entomology, 47(5), 911-914. https://doi.org/10.1111/een.13155

As with other species linked to agricultural environments, many bumblebee species are exhibiting significant population declines. This study assesses the success of colonies of Bombus terrestris audax on farms differing in conservation inputs via agr... Read More about The effect of agri-environment schemes on Bombus terrestris colony success.

A genome-scale metabolic model of Cupriavidus necator H16 integrated with TraDIS and transcriptomic data reveals metabolic insights for biotechnological applications (2022)
Journal Article
Pearcy, N., Garavaglia, M., Millat, T., Gilbert, J. P., Song, Y., Hartman, H., …Minton, N. P. (2022). A genome-scale metabolic model of Cupriavidus necator H16 integrated with TraDIS and transcriptomic data reveals metabolic insights for biotechnological applications. PLoS Computational Biology, 18(5), Article e1010106. https://doi.org/10.1371/journal.pcbi.1010106

Exploiting biological processes to recycle renewable carbon into high value platform chemicals provides a sustainable and greener alternative to current reliance on petrochemicals. In this regard Cupriavidus necator H16 represents a particularly prom... Read More about A genome-scale metabolic model of Cupriavidus necator H16 integrated with TraDIS and transcriptomic data reveals metabolic insights for biotechnological applications.