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The Use and Effectiveness of Selected Alternative Markers for Insulin Sensitivity and Secretion Compared with Gold Standard Markers in Dietary Intervention Studies in Individuals without Diabetes: Results of a Systematic Review

Vazquez Rocha, Lucia; Macdonald, Ian; Alssema, Marjan; Færch, Kristine

The Use and Effectiveness of Selected Alternative Markers for Insulin Sensitivity and Secretion Compared with Gold Standard Markers in Dietary Intervention Studies in Individuals without Diabetes: Results of a Systematic Review Thumbnail


Authors

Ian Macdonald

Marjan Alssema

Kristine Færch



Abstract

Background: The gold‐standard techniques for measuring insulin sensitivity and secretion are well established. However, they may be perceived as invasive and expensive for use in dietary intervention studies. Thus, surrogate markers have been proposed as alternative markers for insulin sensitivity and secretion. This systematic review aimed to identify markers of insulin sensitivity and secretion in response to dietary intervention and assess their suitability as surrogates for the gold‐standard method-ology. Methods: Three databases, PubMed, Scopus, and Cochrane were searched, intervention studies and randomised controlled trials reporting data on dietary intake, a gold standard of analysis of insulin sensitivity (either euglycaemic‐hyperinsulinaemic clamp or intravenous glucose tolerance test and secretion (acute insulin response to glucose), as well as surrogate markers for insulin sensitivity (either fasting insulin, area under the curve oral glucose tolerance tests and HOMA‐IR) and insulin secretion (disposi-tion index), were selected. Results: We identified thirty‐five studies that were eligible for inclusion. We found insufficient evidence to predict insulin sensitivity and secretion with surrogate markers when compared to gold standards in nutritional intervention studies. Conclusions: Future research is needed to investigate if surrogate measures of insulin sensitivity and secretion can be repeatable and reproduci-ble in the same way as gold standards.

Journal Article Type Article
Acceptance Date May 10, 2022
Online Publication Date May 12, 2022
Publication Date May 12, 2022
Deposit Date Jul 11, 2022
Publicly Available Date Jul 11, 2022
Journal Nutrients
Electronic ISSN 2072-6643
Publisher MDPI AG
Peer Reviewed Peer Reviewed
Volume 14
Issue 10
Article Number 2036
DOI https://doi.org/10.3390/nu14102036
Keywords Food Science; Nutrition and Dietetics
Public URL https://nottingham-repository.worktribe.com/output/8947339
Publisher URL https://www.mdpi.com/2072-6643/14/10/2036

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