All Outputs (176)

Functional and immunogenic characterization of diverse HCV glycoprotein E2 variants (2018)
Journal Article
Khera, T., Behrendt, P., Bankwitz, D., Brown, R. J., Todt, D., Doepke, M., …Pietschmann, T. (2019). Functional and immunogenic characterization of diverse HCV glycoprotein E2 variants. Journal of Hepatology, 70(4), 593-602. https://doi.org/10.1016/j.jhep.2018.11.003

© 2018 European Association for the Study of the Liver Background & Aims: Induction of cross-reactive antibodies targeting conserved epitopes of the envelope proteins E1E2 is a key requirement for an hepatitis C virus vaccine. Conserved epitopes like... Read More about Functional and immunogenic characterization of diverse HCV glycoprotein E2 variants.

Monitoring of fluconazole and caspofungin activity against in vivo Candida glabrata biofilms by bioluminescence imaging (2018)
Journal Article
Persyn, A., Rogiers, O., Brock, M., Vande Velde, G., Lamkanfi, M., Jacobsen, I. D., …Kucharíková, S. (2018). Monitoring of fluconazole and caspofungin activity against in vivo Candida glabrata biofilms by bioluminescence imaging. Antimicrobial Agents and Chemotherapy, 63(2), https://doi.org/10.1128/aac.01555-18

Candida glabrata can attach to various medical implants and forms thick biofilms despite its inability to switch from-yeast-to hyphae. Current in vivo C. glabrata biofilm models only provide limited information about colonization and infection and us... Read More about Monitoring of fluconazole and caspofungin activity against in vivo Candida glabrata biofilms by bioluminescence imaging.

The effect of hyperglycemia on neurovascular coupling and cerebrovascular patterning in zebrafish (2018)
Journal Article
Chhabria, K., Plant, K., Bandmann, O., Wilkinson, R. N., Martin, C., Kugler, E., …Howarth, C. (2020). The effect of hyperglycemia on neurovascular coupling and cerebrovascular patterning in zebrafish. Journal of Cerebral Blood Flow and Metabolism, 40(2), 298-313. https://doi.org/10.1177/0271678X18810615

Neurovascular coupling (through which local cerebral blood flow changes in response to neural activation are mediated) is impaired in many diseases including diabetes. Current preclinical rodent models of neurovascular coupling rely on invasive surge... Read More about The effect of hyperglycemia on neurovascular coupling and cerebrovascular patterning in zebrafish.

Musculoskeletal radiology teaching at a UK medical school-do we need to improve? (2018)
Journal Article
Marino, K., Merrick, D., Edwards, K., & Pratten, M. (2019). Musculoskeletal radiology teaching at a UK medical school-do we need to improve?. Anatomical Sciences Education, 12(3), 257-263. doi:10.1002/ase.1834

The United Kingdom is currently facing crisis due to a shortage of radiology consultants despite ever‐increasing demand for medical imaging. The specifics of how best to teach radiology has generated increasing interest. This study aims to determine... Read More about Musculoskeletal radiology teaching at a UK medical school-do we need to improve?.

Lamina-specific population encoding of cutaneous signals in the spinal dorsal horn using multi-electrode arrays (2018)
Journal Article
Greenspon, C. M., Battell, E. E., Devonshire, I. M., Donaldson, L. F., Chapman, V., & Hathway, G. J. (2019). Lamina-specific population encoding of cutaneous signals in the spinal dorsal horn using multi-electrode arrays. Journal of Physiology, 597(2), 377-397. https://doi.org/10.1113/jp277036

The dorsal spinal cord (DH) is a complex laminar structure integrating peripheral signals into the central nervous system. Spinal somatosensory processing is commonly measured electrophysiologically in vivo by recording the activity of individual Wid... Read More about Lamina-specific population encoding of cutaneous signals in the spinal dorsal horn using multi-electrode arrays.

The Rnf complex is an energy-coupled transhydrogenase essential to reversibly link cellular NADH and ferredoxin pools in the acetogen acetobacterium woodii (2018)
Journal Article
Westphal, L., Wiechmann, A., Baker, J., Minton, N. P., & Müller, V. (2018). The Rnf complex is an energy-coupled transhydrogenase essential to reversibly link cellular NADH and ferredoxin pools in the acetogen acetobacterium woodii. Journal of Bacteriology, 200(21), https://doi.org/10.1128/JB.00357-18

© 2018 American Society for Microbiology. The Rnf complex is a respiratory enzyme that catalyzes the oxidation of reduced ferredoxin to the reduction of NAD + , and the negative free energy change of this reaction is used to generate a transmembrane... Read More about The Rnf complex is an energy-coupled transhydrogenase essential to reversibly link cellular NADH and ferredoxin pools in the acetogen acetobacterium woodii.

p53 mutants cooperate with HIF-1 in transcriptional regulation of extracellular matrix components to promote tumor progression (2018)
Journal Article
Amelio, I., Antonov, A. A., Mancini, M., Petrova, V., Cairns, R. A., Vikhreva, P., …Melino, G. (2018). p53 mutants cooperate with HIF-1 in transcriptional regulation of extracellular matrix components to promote tumor progression. Proceedings of the National Academy of Sciences, 115(46), E10869-E10878. https://doi.org/10.1073/pnas.1808314115

Mutations in the TP53 gene and microenvironmentally driven activation of hypoxia-inducible factor-1 (HIF-1) typically occur in later stages of tumorigenesis. An ongoing challenge is the identification of molecular determinants of advanced cancer path... Read More about p53 mutants cooperate with HIF-1 in transcriptional regulation of extracellular matrix components to promote tumor progression.

Estimating species distribution and abundance in river networks using environmental DNA (2018)
Journal Article
Rinaldo, A., Carraro, L., Bertuzzo, E., Hartikainen, H., & Jokela, J. (2018). Estimating species distribution and abundance in river networks using environmental DNA. Proceedings of the National Academy of Sciences, 115(46), 11724-11729. https://doi.org/10.1073/pnas.1813843115

All organisms leave traces of DNA in their environment. This environmental DNA (eDNA) is often used to track occurrence patterns of target species. Applications are especially promising in rivers, where eDNA can integrate information about population... Read More about Estimating species distribution and abundance in river networks using environmental DNA.

Infection Augments Expression of Mechanosensing Piezo1 Channels in Amyloid Plaque-Reactive Astrocytes (2018)
Journal Article
Velasco-Estevez, M., Mampay, M., Boutin, H., Chaney, A., Warn, P., Sharp, A., …Sheridan, G. K. (2018). Infection Augments Expression of Mechanosensing Piezo1 Channels in Amyloid Plaque-Reactive Astrocytes. Frontiers in Aging Neuroscience, 10, Article 332. https://doi.org/10.3389/fnagi.2018.00332

© 2018 Velasco-Estevez, Mampay, Boutin, Chaney, Warn, Sharp, Burgess, Moeendarbary, Dev and Sheridan. A defining pathophysiological hallmark of Alzheimer's disease (AD) is the amyloid plaque; an extracellular deposit of aggregated fibrillar Aβ142 pep... Read More about Infection Augments Expression of Mechanosensing Piezo1 Channels in Amyloid Plaque-Reactive Astrocytes.

Relationships between muscle size, strength, and physical activity in adults with muscular dystrophy: Muscle strength, size and physical activity in muscular dystrophy (2018)
Journal Article
Jacques, M. F., Onambele-Pearson, G. L., Reeves, N. D., Stebbings, G. K., Smith, J., & Morse, C. I. (2018). Relationships between muscle size, strength, and physical activity in adults with muscular dystrophy: Muscle strength, size and physical activity in muscular dystrophy. Journal of Cachexia, Sarcopenia and Muscle, 9(6), 1042-1052. https://doi.org/10.1002/jcsm.12347

Background Muscular dystrophy (MD) is characterized by progressive muscle wasting and weakness, yet few comparisons to non-MD controls (CTRL) of muscle strength and size in this adult population exist. Physical activity (PA) is promoted to maintain... Read More about Relationships between muscle size, strength, and physical activity in adults with muscular dystrophy: Muscle strength, size and physical activity in muscular dystrophy.

Obese subcutaneous adipose tissue impairs human myogenesis, particularly in old skeletal muscle, via resistin-mediated activation of NFκB (2018)
Journal Article
O’Leary, M. F., Wallace, G. R., Davis, E. T., Murphy, D. P., Nicholson, T., Bennett, A. J., …Jones, S. W. (2018). Obese subcutaneous adipose tissue impairs human myogenesis, particularly in old skeletal muscle, via resistin-mediated activation of NFκB. Scientific Reports, 8(1), Article 15360. https://doi.org/10.1038/s41598-018-33840-x

Adiposity and adipokines are implicated in the loss of skeletal muscle mass with age and in several chronic disease states. The aim of this study was to determine the effects of human obese and lean subcutaneous adipose tissue secretome on myogenesis... Read More about Obese subcutaneous adipose tissue impairs human myogenesis, particularly in old skeletal muscle, via resistin-mediated activation of NFκB.

Human SETMAR is a DNA sequence-specific histone-methylase with a broad effect on the transcriptome (2018)
Journal Article
Tellier, M., & Chalmers, R. (2019). Human SETMAR is a DNA sequence-specific histone-methylase with a broad effect on the transcriptome. Nucleic Acids Research, 47(1), 122–133. https://doi.org/10.1093/nar/gky937

Transposons impart dynamism to the genomes they inhabit and their movements frequently rewire the control of nearby genes. Occasionally, their proteins are domesticated when they evolve a new function. SETMAR is a protein methylase with a sequence-sp... Read More about Human SETMAR is a DNA sequence-specific histone-methylase with a broad effect on the transcriptome.

Consensus report of the 8 and 9th Weinman Symposia on Gene x Environment Interaction in carcinogenesis: novel opportunities for precision medicine (2018)
Journal Article
Carbone, M., Amelio, I., Affar, E. B., Brugarolas, J., Cannon-Albright, L. A., Cantley, L. C., …Melino, G. (2018). Consensus report of the 8 and 9th Weinman Symposia on Gene x Environment Interaction in carcinogenesis: novel opportunities for precision medicine. Cell Death and Differentiation, 25(11), 1885-1904. https://doi.org/10.1038/s41418-018-0213-5

The relative contribution of intrinsic genetic factors and extrinsic environmental ones to cancer aetiology and natural history is a lengthy and debated issue. Gene–environment interactions (G x E) arise when the combined presence of both a germline... Read More about Consensus report of the 8 and 9th Weinman Symposia on Gene x Environment Interaction in carcinogenesis: novel opportunities for precision medicine.

Cysteines and Disulfide-Bridged Macrocyclic Mimics of Teixobactin Analogues and Their Antibacterial Activity Evaluation against Methicillin-Resistant Staphylococcus Aureus (MRSA) (2018)
Journal Article
Malkawi, R., Iyer, A., Parmar, A., Lloyd, D. G., Lloyd, D., Leng Goh, E. T., …Singh, I. (2018). Cysteines and Disulfide-Bridged Macrocyclic Mimics of Teixobactin Analogues and Their Antibacterial Activity Evaluation against Methicillin-Resistant Staphylococcus Aureus (MRSA). Pharmaceutics, 10(4), Article 183. https://doi.org/10.3390/pharmaceutics10040183

Teixobactin is a highly potent cyclic depsipeptide which kills a broad range of multi-drug resistant, Gram-positive bacteria, such as Methicillin-resistant Staphylococcus aureus (MRSA) without detectable resistance. In this work, we describe the desi... Read More about Cysteines and Disulfide-Bridged Macrocyclic Mimics of Teixobactin Analogues and Their Antibacterial Activity Evaluation against Methicillin-Resistant Staphylococcus Aureus (MRSA).

13C Pyruvate Transport Across the Blood-Brain Barrier in Preclinical Hyperpolarised MRI (2018)
Journal Article
Miller, J. J., Grist, J. T., Serres, S., Larkin, J. R., Lau, A. Z., Ray, K., …Sibson, N. (2018). 13C Pyruvate Transport Across the Blood-Brain Barrier in Preclinical Hyperpolarised MRI. Scientific Reports, 8(1), Article 15082. https://doi.org/10.1038/s41598-018-33363-5

Hyperpolarised MRI with Dynamic Nuclear Polarisation overcomes the fundamental thermodynamic limitations of conventional magnetic resonance, and is translating to human studies with several early-phase clinical trials in progress including early repo... Read More about 13C Pyruvate Transport Across the Blood-Brain Barrier in Preclinical Hyperpolarised MRI.

Monoamine oxidase-A promotes protective autophagy in human SH-SY5Y neuroblastoma cells through Bcl-2 phosphorylation (2018)
Journal Article
Ugun-Klusek, A., Theodosi, T. S., Fitzgerald, J. C., Burté, F., Ufer, C., Boocock, D. J., …Billett, E. E. (2019). Monoamine oxidase-A promotes protective autophagy in human SH-SY5Y neuroblastoma cells through Bcl-2 phosphorylation. Redox Biology, 20, 167-181. https://doi.org/10.1016/j.redox.2018.10.003

Monoamine oxidases (MAOs) are located on the outer mitochondrial membrane and are drug targets for the treatment of neurological disorders. MAOs control the levels of neurotransmitters in the brain via oxidative deamination and contribute to reactive... Read More about Monoamine oxidase-A promotes protective autophagy in human SH-SY5Y neuroblastoma cells through Bcl-2 phosphorylation.

Molecular recognition of lipopolysaccaride by the lantibiotic nisin (2018)
Journal Article
Lanne, A. B., Goode, A., Prattley, C., Kumari, D., Drasbek, M. R., Williams, P., …Bonev, B. B. (2019). Molecular recognition of lipopolysaccaride by the lantibiotic nisin. BBA - Biomembranes, 1861(1), 83-92. https://doi.org/10.1016/j.bbamem.2018.10.006

Nisin is a lanthionine antimicrobial effective against diverse Gram-positive bacteria and is used as a food preservative worldwide. Its action is mediated by pyrophosphate recognition of the bacterial cell wall receptors lipid II and undecaprenyl pyr... Read More about Molecular recognition of lipopolysaccaride by the lantibiotic nisin.

Novel combinations of agents targeting translation that synergistically inhibit fungal pathogens (2018)
Journal Article
Vallières, C., Raulo, R., Dickinson, M., & Avery, S. V. (2018). Novel combinations of agents targeting translation that synergistically inhibit fungal pathogens. Frontiers in Microbiology, 9, Article 2355. https://doi.org/10.3389/fmicb.2018.02355

A range of fungicides or antifungals are currently deployed to control fungi in agriculture or medicine, but resistance to current agents is growing so new approaches and molecular targets are urgently needed. Recently, different aminoglycoside antib... Read More about Novel combinations of agents targeting translation that synergistically inhibit fungal pathogens.

Rapid and accurate analysis of stem cell-derived extracellular vesicles with super resolution microscopy and live imaging (2018)
Journal Article
Nizamudeen, Z., Markus, R., Lodge, R., Parmenter, C., Platt, M., Chakrabarti, L., & Sottile, V. (2018). Rapid and accurate analysis of stem cell-derived extracellular vesicles with super resolution microscopy and live imaging. Biochimica et Biophysica Acta (BBA) - Molecular Cell Research, 1865(12), 1891-1900. https://doi.org/10.1016/j.bbamcr.2018.09.008

Extracellular vesicles (EVs) have prevalent roles in cancer biology and regenerative medicine. Conventional techniques for characterising EVs including electron microscopy (EM), nanoparticle tracking analysis (NTA) and tuneable resistive pulse sensin... Read More about Rapid and accurate analysis of stem cell-derived extracellular vesicles with super resolution microscopy and live imaging.

Hormones, neurotransmitters, growth factors, receptors, and signaling: Inflammation-associated changes in DOR expression and function in the mouse colon (2018)
Journal Article
Dicello, J., Saito, A., Rajasekhar, P., Eriksson, E., McQuade, R., Nowell, C., …Poole, D. (2018). Hormones, neurotransmitters, growth factors, receptors, and signaling: Inflammation-associated changes in DOR expression and function in the mouse colon. American Journal of Physiology, 315(4), G544-G559. https://doi.org/10.1152/ajpgi.00025.2018

Endoge-nous opioids activate opioid receptors (ORs) in the enteric nervous system to control intestinal motility and secretion. The μ-OR mediates the deleterious side effects of opioid analgesics, including constipation, respiratory depression, and a... Read More about Hormones, neurotransmitters, growth factors, receptors, and signaling: Inflammation-associated changes in DOR expression and function in the mouse colon.