All Outputs (203)

p63 Adjusts Sugar Taste of Epidermal Layers (2017)
Journal Article

p63 is a master regulator of epidermal biology, sustaining stemness and renewal capacity of the proliferating keratinocyte compartment. Hamanaka and Mutlu propose that p63 regulates the keratinocyte proliferation/differentiation switch by affecting t... Read More about p63 Adjusts Sugar Taste of Epidermal Layers.

Real-time analysis of the binding of fluorescent VEGF165a to VEGFR2 in living cells: Effect of receptor tyrosine kinase inhibitors and fate of internalized agonist-receptor complexes (2017)
Journal Article

© 2017 The Authors Vascular endothelial growth factor (VEGF) is an important mediator of angiogenesis. Here we have used a novel stoichiometric protein-labeling method to generate a fluorescent variant of VEGF (VEGF165a-TMR) labeled on a single cyste... Read More about Real-time analysis of the binding of fluorescent VEGF165a to VEGFR2 in living cells: Effect of receptor tyrosine kinase inhibitors and fate of internalized agonist-receptor complexes.

Defining motility in the Staphylococci (2017)
Journal Article

The ability of bacteria to move is critical for their survival in diverse environments and multiple ways have evolved to achieve this. Two forms of motility have recently been described for Staphylococcus aureus, an organism previously considered to... Read More about Defining motility in the Staphylococci.

Intramyocellular lipid content and lipogenic gene expression responses following a single bout of resistance type exercise differ between young and older men (2017)
Journal Article

The aim of this study was to examine the temporal relationship between intramyocellular lipid (IMCL) content and the expression of genes associated with IMCL turnover, fat metabolism, and inflammation during recovery from an acute bout of resistance... Read More about Intramyocellular lipid content and lipogenic gene expression responses following a single bout of resistance type exercise differ between young and older men.

Climate change may drive cave spiders to extinction (2017)
Journal Article

Subterranean ecosystems present ideal opportunities to study mechanisms underlying responses to changes in climate because species within them are often adapted to a largely constant temperature. We have characterized the thermal conditions of caves... Read More about Climate change may drive cave spiders to extinction.

Why prokaryotes have pangenomes (2017)
Journal Article

The existence of large amounts of within-species genome content variability is puzzling. Population genetics tells us that fitness effects of new variants—either deleterious, neutral or advantageous—combined with the long-term effective population si... Read More about Why prokaryotes have pangenomes.

Stress-induced dynamic regulation of mitochondrial STAT3 and its association with cyclophilin D reduces mitochondrial ROS production (2017)
Journal Article

Signal Transducer and Activator of Transcription 3 (STAT3) has been tied to various physiological and pathological functions, mainly as a transcription factor that translocates to the nucleus upon tyrosine phosphorylation induced by cytokine stimulat... Read More about Stress-induced dynamic regulation of mitochondrial STAT3 and its association with cyclophilin D reduces mitochondrial ROS production.

Similarity- and substructure-based development of ?2-adrenergic receptor ligands based on unusual scaffolds (2017)
Journal Article

The ?2-adrenergic receptor (?2AR) is a G protein-coupled receptor (GPCR) and a well-explored target. Here, we report the discovery of 13 ligands, ten of which are novel, of this particular GPCR. They have been identified by similarity- and substructu... Read More about Similarity- and substructure-based development of ?2-adrenergic receptor ligands based on unusual scaffolds.

Tropomyosin 1: multiple roles in the developing heart and in the formation of congenital heart defects (2017)
Journal Article

Tropomyosin 1 (TPM1) is an essential sarcomeric component, stabilising the thin filament and facilitating actin's interaction with myosin. A number of sarcomeric proteins, such as alpha myosin heavy chain, play crucial roles in cardiac development. M... Read More about Tropomyosin 1: multiple roles in the developing heart and in the formation of congenital heart defects.

Vascular endothelial growth factor-A165b ameliorates outer-retinal barrier and vascular dysfunction in the diabetic retina (2017)
Journal Article

Diabetic retinopathy (DR) is one of the leading causes of blindness in the developed world. Characteristic features of DR are retinal neurodegeneration, pathological angiogenesis and breakdown of both the inner and outer retinal barriers of the retin... Read More about Vascular endothelial growth factor-A165b ameliorates outer-retinal barrier and vascular dysfunction in the diabetic retina.

Sensory innervation of perivascular adipose tissue: a crucial role in artery vasodilation and leptin release (2017)
Journal Article

Aims: Electrical field stimulation (EFS) elicits robust sensory neurogenic relaxation responses in the rat isolated mesenteric arterial bed but these responses are absent or difficult to demonstrate in isolated arteries. We believe that this mismatch... Read More about Sensory innervation of perivascular adipose tissue: a crucial role in artery vasodilation and leptin release.

The next generation fungal diversity researcher (2017)
Journal Article

Fungi are more important to our lives than is assumed by the general public. They can comprise both devastating pathogens and plant-associated mutualists in nature, and several species have also become important workhorses of biotechnology. Fungal di... Read More about The next generation fungal diversity researcher.

The soft mechanical signature of glial scars in the central nervous system (2017)
Journal Article

© The Author(s) 2017. Injury to the central nervous system (CNS) alters the molecular and cellular composition of neural tissue and leads to glial scarring, which inhibits the regrowth of damaged axons. Mammalian glial scars supposedly form a chemica... Read More about The soft mechanical signature of glial scars in the central nervous system.

Detection in blood of autoantibodies to tumour antigens as a case-finding method in lung cancer using the EarlyCDT®-Lung Test (ECLS): study protocol for a randomized controlled trial (2017)
Journal Article

Background: Lung cancer is the most common cause of cancer related death worldwide. The majority of cases are detected at a late stage when prognosis is poor. The EarlyCDT®-Lung Test detects autoantibodies to abnormal cell surface proteins in the ear... Read More about Detection in blood of autoantibodies to tumour antigens as a case-finding method in lung cancer using the EarlyCDT®-Lung Test (ECLS): study protocol for a randomized controlled trial.

Same-day diagnostic and surveillance data for tuberculosis via whole genome sequencing of direct respiratory samples (2017)
Journal Article

Routine full characterization of Mycobacterium tuberculosis (TB) is culture-based, taking many weeks. Whole-genome sequencing (WGS) can generate antibiotic susceptibility profiles to inform treatment, augmented with strain information for global surv... Read More about Same-day diagnostic and surveillance data for tuberculosis via whole genome sequencing of direct respiratory samples.

The role of indoleamine 2,3-dioxygenase-aryl hydrocarbon receptor pathway in the TLR4-induced tolerogenic phenotype in human DCs (2017)
Journal Article

A controlled inflammatory response is required for protection against infection, but persistent inflammation causes tissue damage. Dendritic cells (DCs) have a unique capacity to promote both inflammatory and anti-inflammatory processes. One key mech... Read More about The role of indoleamine 2,3-dioxygenase-aryl hydrocarbon receptor pathway in the TLR4-induced tolerogenic phenotype in human DCs.

Precipitation drives global variation in natural selection (2017)
Journal Article

Climate change has the potential to affect the ecology and evolution of every species on Earth. While the ecological consequences of climate change are increasingly well documented, the effects of climate on the key evolutionary process driving adapt... Read More about Precipitation drives global variation in natural selection.

High tolerance to self-targeting of the genome by the endogenous CRISPR-Cas system in an archaeon (2017)
Journal Article

CRISPR-Cas systems allow bacteria and archaea to acquire sequence-specific immunity against selfish genetic elements such as viruses and plasmids, by specific degradation of invader DNA or RNA. However, this involves the risk of autoimmunity if immun... Read More about High tolerance to self-targeting of the genome by the endogenous CRISPR-Cas system in an archaeon.

NMN deamidase delays Wallerian degeneration and rescues axonal defects caused by NMNAT2 deficiency in vivo (2017)
Journal Article

Axons require the axonal NAD-synthesizing enzyme NMNAT2 to survive. Injury or genetically-induced depletion of NMNAT2 triggers axonal degeneration or defective axon growth. We have previously proposed that axonal NMNAT2 primarily promotes axon surviv... Read More about NMN deamidase delays Wallerian degeneration and rescues axonal defects caused by NMNAT2 deficiency in vivo.

Cohort profile: the Hepatitis C Virus (HCV) Research UK clinical database and biobank (2017)
Journal Article