Professor JAMES MCINERNEY JAMES.MCINERNEY@NOTTINGHAM.AC.UK
Chair in Evolutionary Biology
Why prokaryotes have pangenomes
McInerney, James O.; McNally, Alan; O'Connell, Mary J.
Authors
Alan McNally
Professor and Chair of Molecular Evolution MARY O'CONNELL MARY.O'CONNELL@NOTTINGHAM.AC.UK
Professor of Molecular Evolution
Abstract
The existence of large amounts of within-species genome content variability is puzzling. Population genetics tells us that fitness effects of new variants—either deleterious, neutral or advantageous—combined with the long-term effective population size of the species determines the likelihood of a new variant being removed, spreading to fixation or remaining polymorphic. Consequently, we expect that selection and drift will reduce genetic variation, which makes large amounts of gene content variation in some species so puzzling. Here, we amalgamate population genetic theory with models of horizontal gene transfer and assert that pangenomes most easily arise in organisms with large long-term effective population sizes, as a consequence of acquiring advantageous genes, and that the focal species has the ability to migrate to new niches. Therefore, we suggest that pangenomes are the result of adaptive, not neutral, evolution.
Citation
McInerney, J. O., McNally, A., & O'Connell, M. J. (2017). Why prokaryotes have pangenomes. Nature Microbiology, 2(4), https://doi.org/10.1038/nmicrobiol.2017.40
Journal Article Type | Article |
---|---|
Acceptance Date | Feb 22, 2017 |
Online Publication Date | Mar 28, 2017 |
Publication Date | 2017-04 |
Deposit Date | Mar 23, 2020 |
Journal | Nature Microbiology |
Electronic ISSN | 2058-5276 |
Publisher | Nature Publishing Group |
Peer Reviewed | Peer Reviewed |
Volume | 2 |
Issue | 4 |
Article Number | 17040 |
DOI | https://doi.org/10.1038/nmicrobiol.2017.40 |
Public URL | https://nottingham-repository.worktribe.com/output/1622969 |
Publisher URL | https://www.nature.com/articles/nmicrobiol201740 |
You might also like
Evidence for Selection in the Abundant Accessory Gene Content of a Prokaryote Pangenome
(2021)
Journal Article
Evidence for selection in a prokaryote pangenome
(2020)
Working Paper
Coinfinder: Detecting significant associations and dissociations in pangenomes
(2020)
Journal Article
Coinfinder: Detecting Significant Associations and Dissociations in Pangenomes
(2019)
Working Paper
Eukaryote genes are more likely than prokaryote genes to be composites
(2019)
Journal Article
Downloadable Citations
About Repository@Nottingham
Administrator e-mail: digital-library-support@nottingham.ac.uk
This application uses the following open-source libraries:
SheetJS Community Edition
Apache License Version 2.0 (http://www.apache.org/licenses/)
PDF.js
Apache License Version 2.0 (http://www.apache.org/licenses/)
Font Awesome
SIL OFL 1.1 (http://scripts.sil.org/OFL)
MIT License (http://opensource.org/licenses/mit-license.html)
CC BY 3.0 ( http://creativecommons.org/licenses/by/3.0/)
Powered by Worktribe © 2024
Advanced Search