All Outputs (225)

Students’ views towards sars-cov-2 mass asymptomatic testing, social distancing and self-isolation in a university setting during the covid-19 pandemic: A qualitative study (2021)
Journal Article

We aimed to explore university students’ perceptions and experiences of SARS-CoV-2 mass asymptomatic testing, social distancing and self-isolation, during the COVID-19 pandemic. This qualitative study comprised of four rapid online focus groups condu... Read More about Students’ views towards sars-cov-2 mass asymptomatic testing, social distancing and self-isolation in a university setting during the covid-19 pandemic: A qualitative study.

New phosphosite-specific antibodies to unravel the role of GRK phosphorylation in dopamine D2 receptor regulation and signaling (2021)
Journal Article

The dopamine D2 receptor (D2R) is the target of drugs used to treat the symptoms of Parkinson’s disease and schizophrenia. The D2R is regulated through its interaction with and phosphorylation by G protein receptor kinases (GRKs) and interaction with... Read More about New phosphosite-specific antibodies to unravel the role of GRK phosphorylation in dopamine D2 receptor regulation and signaling.

Combining Inducible Lectin Expression and Magnetic Glyconanoparticles for the Selective Isolation of Bacteria from Mixed Populations (2021)
Journal Article

The selective isolation of bacteria from mixed populations has been investigated in varied applications ranging from differential pathogen identification in medical diagnostics and food safety to the monitoring of microbial stress dynamics in industr... Read More about Combining Inducible Lectin Expression and Magnetic Glyconanoparticles for the Selective Isolation of Bacteria from Mixed Populations.

Variants in urate transporters, ADH1B, GCKR and MEPE genes associate with transition from asymptomatic hyperuricaemia to gout: Results of the first gout versus asymptomatic hyperuricaemia GWAS in Caucasians using data from the UK Biobank (2021)
Journal Article

Objectives: To perform a genome-wide association study (GWAS) of gout cases vs. asymptomatic hyperuricaemia (AH) controls, and gout cases vs. normouricaemia controls, and to generate a polygenic risk score (PRS) to determine gout-case vs. AH-control... Read More about Variants in urate transporters, ADH1B, GCKR and MEPE genes associate with transition from asymptomatic hyperuricaemia to gout: Results of the first gout versus asymptomatic hyperuricaemia GWAS in Caucasians using data from the UK Biobank.

Magnesium and calcium overaccumulate in the leaves of a schengen3 mutant of Brassica rapa (2021)
Journal Article

Magnesium (Mg) and calcium (Ca) are essential mineral nutrients poorly supplied in many human food systems. In grazing livestock, Mg and Ca deficiencies are costly welfare issues. Here, we report a Brassica rapa loss-of-function schengen3 (sgn3) muta... Read More about Magnesium and calcium overaccumulate in the leaves of a schengen3 mutant of Brassica rapa.

Mobilizing molluscan models and genomes in biology (2021)
Journal Article

Molluscs are among the most ancient, diverse, and important of all animal taxa. Even so, no individual mollusc species has emerged as a broadly applied model system in biology. We here make the case that both perceptual and methodological barriers ha... Read More about Mobilizing molluscan models and genomes in biology.

Pearls of wisdom—a Theo Murphy issue on molluscan genomics (2021)
Journal Article

Improved CRISPR/Cas9 Tools for the Rapid Metabolic Engineering of Clostridium acetobutylicum (2021)
Journal Article

Clustered regularly interspaced short palindromic repeats (CRISPR)/Cas (CRISPR-associated proteins)9 tools have revolutionized biology—several highly efficient tools have been constructed that have resulted in the ability to quickly engineer model ba... Read More about Improved CRISPR/Cas9 Tools for the Rapid Metabolic Engineering of Clostridium acetobutylicum.

Study Protocol: The Heart and Brain Study (2021)
Journal Article

Background: It is well-established that what is good for the heart is good for the brain. Vascular factors such as hypertension, diabetes, and high cholesterol, and genetic factors such as the apolipoprotein E4 allele increase the risk of developing... Read More about Study Protocol: The Heart and Brain Study.

Zebrafish as a tractable model of human cardiovascular disease (2021)
Journal Article

Mammalian models including non-human primates, pigs and rodents have been used extensively to study the mechanisms of cardiovascular disease. However, there is an increasing desire for alternative model systems that provide excellent scientific value... Read More about Zebrafish as a tractable model of human cardiovascular disease.

Mitigating the foreign body response through ‘immune-instructive’ biomaterials (2021)
Journal Article

Objectives Biomaterials are routinely used in clinical applications. A key to the clinical success of implanted biomaterials is not eliciting detrimental immune responses. In this article, we provide an overview of immune responses to biomaterials,... Read More about Mitigating the foreign body response through ‘immune-instructive’ biomaterials.

Novelty and Convergence in Adaptation to Whole Genome Duplication (2021)
Journal Article

Whole genome duplication (WGD) can promote adaptation but is disruptive to conserved processes, especially meiosis. Studies in Arabidopsis arenosa revealed a coordinated evolutionary response to WGD involving interacting proteins controlling meiotic... Read More about Novelty and Convergence in Adaptation to Whole Genome Duplication.

Seasonal patterns in habitat use by the harvest mouse (Micromys minutus) and other small mammals (2021)
Journal Article

The ecology of the harvest mouse (Micromys minutus) is poorly understood, partly because it is a difficult species to monitor. It is commonly associated with reedbeds, where evidence suggests that it experiences strong seasonal fluctuations in abunda... Read More about Seasonal patterns in habitat use by the harvest mouse (Micromys minutus) and other small mammals.

Exploration of the 2016 Yellowstone River fish kill and proliferative kidney disease in wild fish populations (2021)
Journal Article

Proliferative kidney disease (PKD) is an emerging disease that recently resulted in a large mortality event of salmonids in the Yellowstone River (Montana, USA). Total PKD fish mortalities in the Yellowstone River were estimated in the tens of thousa... Read More about Exploration of the 2016 Yellowstone River fish kill and proliferative kidney disease in wild fish populations.

Trypanosome KKIP1 Dynamically Links the Inner Kinetochore to a Kinetoplastid Outer Kinetochore Complex (2021)
Journal Article

Kinetochores perform an essential role in eukaryotes, coupling chromosomes to the mitotic spindle. In model organisms they are composed of a centromere-proximal inner kinetochore and an outer kinetochore network that binds to microtubules. In spite o... Read More about Trypanosome KKIP1 Dynamically Links the Inner Kinetochore to a Kinetoplastid Outer Kinetochore Complex.

Human lung-on-chips: Advanced systems for respiratory virus models and assessment of immune response (2021)
Journal Article

Respiratory viral infections are leading causes of death worldwide. A number of human respiratory viruses circulate in all age groups and adapt to person-to-person transmission. It is vital to understand how these viruses infect the host and how the... Read More about Human lung-on-chips: Advanced systems for respiratory virus models and assessment of immune response.

Hybrid assembly of an agricultural slurry virome reveals a diverse and stable community with the potential to alter the metabolism and virulence of veterinary pathogens (2021)
Journal Article

Viruses are the most abundant biological entities on Earth, known to be crucial components of microbial ecosystems. However, there is little information on the viral community within agricultural waste. There are currently ~ 2.7 million dairy cattle... Read More about Hybrid assembly of an agricultural slurry virome reveals a diverse and stable community with the potential to alter the metabolism and virulence of veterinary pathogens.

Potentiated inhibition of Trichoderma virens and other environmental fungi by new biocide combinations (2021)
Journal Article

Fungi cause diverse, serious socio-economic problems, including biodeterioration of valuable products and materials that spawns a biocides industry worth ~$11 billion globally. To help combat environmental fungi that commonly colonise material produc... Read More about Potentiated inhibition of Trichoderma virens and other environmental fungi by new biocide combinations.

Extracellular Vesicles and Intercellular Communication in the Central Nervous System (2021)
Journal Article

Neurons and glial cells of the central nervous system (CNS) release extracellular vesicles (EVs) to the interstitial fluid of the brain and spinal cord parenchyma. EVs contain proteins, nucleic acids and lipids that can be taken up by, and modulate t... Read More about Extracellular Vesicles and Intercellular Communication in the Central Nervous System.

Analysis of sequence divergence in mammalian abcgs predicts a structural network of residues that underlies functional divergence (2021)
Journal Article

© 2021 by the authors. Licensee MDPI, Basel, Switzerland. The five members of the mammalian G subfamily of ATP-binding cassette transporters differ greatly in their substrate specificity. Four members of the subfamily are important in lipid transport... Read More about Analysis of sequence divergence in mammalian abcgs predicts a structural network of residues that underlies functional divergence.