Zebrafish as a tractable model of human cardiovascular disease

Bowley, George; Kugler, Elizabeth; Wilkinson, Rob; Lawrie, Allan; Eeden, Freek; Chico, Tim J. A.; Evans, Paul C.; No�l, Emily S.; Serbanovic?Canic, Jovana

Abstract

Mammalian models including non-human primates, pigs and rodents have been used extensively to study the mechanisms of cardiovascular disease. However, there is an increasing desire for alternative model systems that provide excellent scientific value while replacing or reducing the use of mammals. Here, we review the use of zebrafish, Danio rerio, to study cardiovascular development and disease. The anatomyand physiology of zebrafish and mammalian cardiovascular systems are compared, and we describe the use of zebrafish models in studying the mechanisms of cardiac (e.g. congenital heart defects, cardiomyopathy, conduction disorders and regeneration) and vascular (endothelial dysfunction and atherosclerosis, lipid metabolism, vascular ageing, neurovascular physiology and stroke) pathologies. We also review the use of zebrafish for studying pharmacological responses to cardiovascular drugs and describe several features of zebrafish that make them a compelling model forin vivo screening of compounds for the treatment cardiovascular disease.

Citation

Bowley, G., Kugler, E., Wilkinson, R., Lawrie, A., Eeden, F., Chico, T. J. A., …Serbanovic‐Canic, J. (2022). Zebrafish as a tractable model of human cardiovascular disease. British Journal of Pharmacology, 179(5), 900-917. https://doi.org/10.1111/bph.15473

• Journal Article Type: Review
• Acceptance Date: Mar 24, 2021
• Online Publication Date: Mar 31, 2021
• Publication Date: Mar 1, 2022
• Deposit Date: Nov 1, 2021
• Publicly Available Date: Nov 3, 2021
• Journal: British Journal of Pharmacology
• Print ISSN: 0007-1188
• Electronic ISSN: 1476-5381
• Publisher: Wiley
• Peer Reviewed: Peer Reviewed
• Volume: 179
• Issue: 5
• Pages: 900-917
• DOI: https://doi.org/10.1111/bph.15473
• Keywords: Pharmacology
• Public URL: https://nottingham-repository.worktribe.com/output/6605963
• Publisher URL: https://bpspubs.onlinelibrary.wiley.com/doi/10.1111/bph.15473