All Outputs (172)

Cell response to plasma electrolytic oxidation surface-modified low-modulus ?-type titanium alloys (2018)
Journal Article

Plasma electrolytic oxidation (PEO) has been demonstrated to be an effective surface treatment for enhancing the osteoconduction and osseointegration of commercially pure ?-Ti (CP ?-Ti) dental implant materials for clinical application. To explore th... Read More about Cell response to plasma electrolytic oxidation surface-modified low-modulus ?-type titanium alloys.

Cell death pathologies: targeting death pathways and the immune system for cancer therapy (2018)
Journal Article

Alterations in the molecular mechanisms of cell death are a common feature of cancer. These alterations enable malignant cells to survive intrinsic death signalling leading to accumulation of genetic aberrations and helping them to cope with adverse... Read More about Cell death pathologies: targeting death pathways and the immune system for cancer therapy.

Neurovascular structures in human vastus lateralis muscle and the ideal biopsy site (2018)
Journal Article

A density model of neurovascular structures was generated from 28 human vastus lateralis muscles isolated from embalmed cadavers. The intramuscular portion of arteries, veins and nerves was dissected, traced on transparencies and digitised before adj... Read More about Neurovascular structures in human vastus lateralis muscle and the ideal biopsy site.

SOX9 regulated matrix proteins are increased in patients serum and correlate with severity of liver fibrosis (2018)
Journal Article

Extracellular matrix (ECM) deposition and resultant scar play a major role in the pathogenesis and progression of liver fibrosis. Identifying core regulators of ECM deposition may lead to urgently needed diagnostic and therapetic strategies for the d... Read More about SOX9 regulated matrix proteins are increased in patients serum and correlate with severity of liver fibrosis.

Profiling of 54 plasma glycoproteins by label-free targeted LC-MS/MS (2018)
Journal Article

Glycoproteins play a central role in diverse biological processes and are linked with many serious human diseases. In this paper we present a simple, reproducible and cost-effective analytical workflow that enables the reliable quantification of clin... Read More about Profiling of 54 plasma glycoproteins by label-free targeted LC-MS/MS.

Plasmodium centrin PbCEN-4 localizes to the putative MTOC and is dispensable for malaria parasite proliferation (2018)
Journal Article

Centrins are calmodulin-like phosphoproteins present in the centrosome and play an active role in the duplication, separation and organization of centrosomal structures such as the microtubule-organizing centre (MTOC) during mitosis. They are also ma... Read More about Plasmodium centrin PbCEN-4 localizes to the putative MTOC and is dispensable for malaria parasite proliferation.

Cooperation between protein kinase A (PKA) and high osmolarity glycerol reponse (HOG) pathways is affecting cell wall carbohydrate mobilization in Aspergillus fumigatus (2018)
Journal Article

Aspergillus fumigatus mitogen-activated protein kinases (MAPKs) are involved in maintaining the normal morphology of the cell wall and providing resistance against cell wall-damaging agents. Upon cell wall stress, cell wall-related sugars need to be... Read More about Cooperation between protein kinase A (PKA) and high osmolarity glycerol reponse (HOG) pathways is affecting cell wall carbohydrate mobilization in Aspergillus fumigatus.

The use of decellularised animal tissue to study disseminating cancer cells (2018)
Journal Article

Since the establishment of cell culture, common practice has been to grow adherent cells in 2D monolayers. Although cells behave completely differently when grown under these artificial conditions, the ease of 2D culturing has meant that this practic... Read More about The use of decellularised animal tissue to study disseminating cancer cells.

TAp73 regulates ATP7A: possible implications for ageing-related diseases (2018)
Journal Article

The p53 family member p73 controls a wide range of cellular function. Deletion of p73 in mice results in increased tumorigenesis, infertility, neurological defects and altered immune system. Despite the extensive effort directed to define the molecul... Read More about TAp73 regulates ATP7A: possible implications for ageing-related diseases.

Cross-chemistry leads to product diversity from atromentin synthetases in Aspergilli from section Nigri (2018)
Journal Article

Nonribosomal peptide synthetase (NRPS)-like enzymes catalyse the non-oxidative homodimerisation of aromatic ?-keto acids, but the exact reaction mechanism is unknown. The furanone-forming thioesterase domain of the Aspergillus terreus aspulvinone E s... Read More about Cross-chemistry leads to product diversity from atromentin synthetases in Aspergilli from section Nigri.

The role of oral antibiotic preparation in elective colorectal surgery: a meta-analysis (2018)
Journal Article

© 2018 The Author(s). Published by Wolters Kluwer Health, Inc. Objectives:To compare the impact of the use of oral antibiotics (OAB) with or without mechanical bowel preparation (MBP) on outcome in elective colorectal surgery.Summary Background Data:... Read More about The role of oral antibiotic preparation in elective colorectal surgery: a meta-analysis.

Sustained protein synthesis and reduced eEF2K levels in TAp73-\- mice brain: a possible compensatory mechanism (2018)
Journal Article

The transcription factor p73 is a member of the p53 family, of which the transactivation domain containing isoform (TAp73) plays key roles in brain development and neuronal stem cells. TAp73 also facilitates homoeostasis and prevents oxidative damage... Read More about Sustained protein synthesis and reduced eEF2K levels in TAp73-\- mice brain: a possible compensatory mechanism.

The impact of anxiety on chronic musculoskeletal pain and the role of astrocyte activation (2018)
Journal Article

© 2018 International Association for the Study of Pain. Anxiety and depression are associated with increased pain responses in chronic pain states. The extent to which anxiety drives chronic pain, or vice versa, remains an important question that has... Read More about The impact of anxiety on chronic musculoskeletal pain and the role of astrocyte activation.

The Synthetic Genome Summer Course (2018)
Journal Article

Epidemiology and natural history of hepatitis C virus infection among children and young people (2018)
Journal Article

Parts list for a microtubule depolymerising kinesin (2018)
Journal Article

The Kinesin superfamily is a large group of molecular motors that use the turnover of ATP to regulate their interaction with the microtubule cytoskeleton. The coupled relationship between nucleotide turnover and microtubule binding is harnessed in va... Read More about Parts list for a microtubule depolymerising kinesin.

Start-Stop Assembly: a functionally scarless DNA assembly system optimized for metabolic engineering (2018)
Journal Article

© The Author(s) 2018. Published by Oxford University Press on behalf of Nucleic Acids Research. DNA assembly allows individual DNA constructs or libraries to be assembled quickly and reliably. Most methods are either: (i) Modular, easily scalable and... Read More about Start-Stop Assembly: a functionally scarless DNA assembly system optimized for metabolic engineering.

BulkVis: a graphical viewer for Oxford nanopore bulk FAST5 files (2018)
Journal Article

Motivation: The Oxford Nanopore Technologies (ONT) MinION is used for sequencing a wide variety of sample types with diverse methods of sample extraction. Nanopore sequencers output FAST5 files containing signal data subsequently base called to FASTQ... Read More about BulkVis: a graphical viewer for Oxford nanopore bulk FAST5 files.

Greater loss of mitochondrial function with ageing is associated with earlier onset of sarcopenia in C. elegans (2018)
Journal Article

Sarcopenia, the age-related decline of muscle, is a significant and growing public health burden. C. elegans, a model organism for investigating the mechanisms of ageing, also displays sarcopenia, but the underlying mechanism(s) remain elusive. Here,... Read More about Greater loss of mitochondrial function with ageing is associated with earlier onset of sarcopenia in C. elegans.

IFN-γ and IL-17A differentially influence the response of human macrophages and neutrophils to Pseudomonas aeruginosa infection (2018)
Journal Article

Macrophages are important orchestrators of inflammation during bacterial infection acting both as effector cells and as regulators of neutrophil recruitment and life span. Differently activated macrophage populations with distinct inflammatory and mi... Read More about IFN-γ and IL-17A differentially influence the response of human macrophages and neutrophils to Pseudomonas aeruginosa infection.