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Parts list for a microtubule depolymerising kinesin

Friel, Claire T.; Welburn, Julie P.

Authors

Julie P. Welburn



Abstract

The Kinesin superfamily is a large group of molecular motors that use the turnover of ATP to regulate their interaction with the microtubule cytoskeleton. The coupled relationship between nucleotide turnover and microtubule binding is harnessed in various ways by these motors allowing them to carry out a variety of cellular functions. The Kinesin-13 family is a group of specialist microtubule depolymerising motors. Members of this family use their microtubule destabilising activity to regulate processes such as chromosome segregation, maintenance of cilia and neuronal development. Here, we describe the current understanding of the structure of this family of kinesins and the role different parts of these proteins play in their microtubule depolymerisation activity and in the wider function of this family of kinesins.

Journal Article Type Article
Publication Date Dec 17, 2018
Journal Biochemical Society Transactions
Print ISSN 0300-5127
Electronic ISSN 1470-8752
Publisher Portland Press
Peer Reviewed Peer Reviewed
Volume 46
Issue 6
Pages 1665-1672
APA6 Citation Friel, C. T., & Welburn, J. P. (2018). Parts list for a microtubule depolymerising kinesin. Biochemical Society Transactions, 46(6), 1665-1672. https://doi.org/10.1042/bst20180350
DOI https://doi.org/10.1042/bst20180350
Publisher URL http://www.biochemsoctrans.org/content/46/6/1665

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