All Outputs (173)

Sexual reproduction of human fungal pathogens (2014)
Journal Article
Heitman, J., Carter, D. A., Dyer, P. S., & Soll, D. R. (in press). Sexual reproduction of human fungal pathogens. Cold Spring Harbor Perspectives in Medicine, 4(8), Article a019281. https://doi.org/10.1101/cshperspect.a019281

We review here recent advances in our understanding of sexual reproduction in fungal pathogens that commonly infect humans, including Candida albicans, Cryptococcus neoformans/gattii, and Aspergillus fumigatus. Where appropriate or relevant, we intro... Read More about Sexual reproduction of human fungal pathogens.

Computational modeling of the effects of auditory nerve dysmyelination (2014)
Journal Article
Brown, A. M., & Hamann, M. (2014). Computational modeling of the effects of auditory nerve dysmyelination. Frontiers in Neuroanatomy, 8(73), https://doi.org/10.3389/fnana.2014.00073

Our previous study showed that exposure to loud sound leading to hearing loss elongated the auditory nerve (AN) nodes of Ranvier and triggered notable morphological changes at paranodes and juxtaparanodes. Here we used computational modeling to exami... Read More about Computational modeling of the effects of auditory nerve dysmyelination.

Development of an ex vivo porcine lung model for studying growth, virulence, and signaling of Pseudomonas aeruginosa (2014)
Journal Article
Harrison, F., Muruli, A., Higgins, S., & Diggle, S. P. (2014). Development of an ex vivo porcine lung model for studying growth, virulence, and signaling of Pseudomonas aeruginosa. Infection and Immunity, 82(8), https://doi.org/10.1128/IAI.01554-14

Research into chronic infection by bacterial pathogens, such as Pseudomonas aeruginosa, uses various in vitro and live host models. While these have increased our understanding of pathogen growth, virulence, and evolution, each model has certain limi... Read More about Development of an ex vivo porcine lung model for studying growth, virulence, and signaling of Pseudomonas aeruginosa.

Molecular characterization of the malaria vector Anopheles barbirostris van der Wulp in Sri Lanka (2014)
Journal Article
Gajapathy, K., Jude, P. J., Goodacre, S., Peiris, L. B., Ramasamy, R., & Surendran, S. N. (2014). Molecular characterization of the malaria vector Anopheles barbirostris van der Wulp in Sri Lanka. Parasites and Vectors, 7(1), Article 348. https://doi.org/10.1186/1756-3305-7-348

Background: Anopheles barbirostris is a vector of malaria in Sri Lanka. The taxon exists as a species complex in the Southeast Asian region. Previous studies using molecular markers suggest that there are more than 4 distinct clades within the An. ba... Read More about Molecular characterization of the malaria vector Anopheles barbirostris van der Wulp in Sri Lanka.

Risk-based learning games improve long-term retention of information among school pupils (2014)
Journal Article
Devonshire, I. M., Davis, J., Fairweather, S., Highfield, L., Thaker, C., Walsh, A., …Hathway, G. J. (2014). Risk-based learning games improve long-term retention of information among school pupils. PLoS ONE, 9(7), Article e103640. https://doi.org/10.1371/journal.pone.0103640

Risk heightens motivation and, if used appropriately, may have the potential to improve engagement in the classroom. We have developed a risk-based learning game for school pupils in order to test whether such learning games can improve later recall... Read More about Risk-based learning games improve long-term retention of information among school pupils.

Simultaneous tissue profiling of eicosanoid and endocannabinoid lipid families in a rat model of osteoarthritis (2014)
Journal Article
Wong, A., Sagar, D. R., Ortori, C. A., Kendall, D. A., Chapman, V., & Barrett, D. A. (2014). Simultaneous tissue profiling of eicosanoid and endocannabinoid lipid families in a rat model of osteoarthritis. Journal of Lipid Research, 55(9), 1902-1913. doi:10.1194/jlr.M048694

We describe a novel LC method for the simultaneous and quantitative profiling of 43 oxylipins including eicosanoids, endocannabinoids, and structurally related bioactive lipids with modified acyl groups. The LC-MS/MS method uses switching at a define... Read More about Simultaneous tissue profiling of eicosanoid and endocannabinoid lipid families in a rat model of osteoarthritis.

Myosin-Va and dynamic actin oppose microtubules to drive long-range organelle transport (2014)
Journal Article
Evans, R. D., Robinson, C., Briggs, D. A., Tooth, D. J., Ramalho, J. S., Cantero, M., …Hume, A. N. (2014). Myosin-Va and dynamic actin oppose microtubules to drive long-range organelle transport. Current Biology, 24(15), 1743-1750. https://doi.org/10.1016/j.cub.2014.06.019

In animal cells, microtubule and actin tracks and their associated motors (dynein, kinesin, and myosin) are thought to regulate long- and short-range transport, respectively [1-8]. Consistent with this, microtubules extend from the perinuclear centro... Read More about Myosin-Va and dynamic actin oppose microtubules to drive long-range organelle transport.

DWI and complex brain network analysis predicts vascular cognitive impairment in spontaneous hypertensive rats undergoing executive function tests (2014)
Journal Article
López-Gil, X., Amat-Roldan, I., Tudela, R., Castańé, A., Prats-Galino, A., Planas, A. M., …Soria, G. (2014). DWI and complex brain network analysis predicts vascular cognitive impairment in spontaneous hypertensive rats undergoing executive function tests. Frontiers in Aging Neuroscience, 6, Article 167. https://doi.org/10.3389/fnagi.2014.00167

The identification of biomarkers of vascular cognitive impairment is urgent for its early diagnosis. The aim of this study was to detect and monitor changes in brain structure and connectivity, and to correlate them with the decline in executive func... Read More about DWI and complex brain network analysis predicts vascular cognitive impairment in spontaneous hypertensive rats undergoing executive function tests.

Real-Time Monitoring of GPCR/cAMP Signalling by FRET and Single-Molecule Microscopy (2014)
Journal Article
Calebiro, D., Sungkaworn, T., & Maiellaro, I. (2014). Real-Time Monitoring of GPCR/cAMP Signalling by FRET and Single-Molecule Microscopy. Hormone and Metabolic Research, 46(12), 827-832. https://doi.org/10.1055/s-0034-1384523

G-protein-coupled receptors (GPCRs), located on the surface of virtually every cell in our organism, mediate the effects of many hormones and neurotransmitters. Although GPCRs have been extensively studied for more than 4 decades using pharmacologica... Read More about Real-Time Monitoring of GPCR/cAMP Signalling by FRET and Single-Molecule Microscopy.

Total synthesis of a eukaryotic chromosome: Redesigning and SCRaMbLE-ing yeast (2014)
Journal Article
Jovicevic, D., Blount, B. A., & Ellis, T. (2014). Total synthesis of a eukaryotic chromosome: Redesigning and SCRaMbLE-ing yeast. BioEssays, 36(9), 855-860. https://doi.org/10.1002/bies.201400086

A team of US researchers recently reported the design, assembly and in vivo functionality of a synthetic chromosome III (SynIII) for the yeast Saccharomyces cerevisiae. The synthetic chromosome was assembled bottom-up from DNA oligomers by teams of s... Read More about Total synthesis of a eukaryotic chromosome: Redesigning and SCRaMbLE-ing yeast.

Inferring mechanisms of copy number change from haplotype structures at the human DEFA1A3 locus (2014)
Journal Article
Black, H. A., Khan, F. F., Tyson, J., & Armour, J. A. (in press). Inferring mechanisms of copy number change from haplotype structures at the human DEFA1A3 locus. BMC Genomics, 15(614), https://doi.org/10.1186/1471-2164-15-614

Background: The determination of structural haplotypes at copy number variable regions can indicate the mechanisms responsible for changes in copy number, as well as explain the relationship between gene copy number and expression. However, obtaining... Read More about Inferring mechanisms of copy number change from haplotype structures at the human DEFA1A3 locus.

Differences in MAT gene distribution and expression between Rhynchosporium species on grasses (2014)
Journal Article
King, K., West, J., Fitt, B., & Dyer, P. S. (2015). Differences in MAT gene distribution and expression between Rhynchosporium species on grasses. Plant Pathology, 64(2), https://doi.org/10.1111/ppa.12265

Leaf blotch is a globally important disease of barley crops and other grasses that is caused by at least five host-specialized species in the fungal genus Rhynchosporium. The pathogen R. commune (specialized to barley, brome-grass and Italian ryegras... Read More about Differences in MAT gene distribution and expression between Rhynchosporium species on grasses.

Genome-wide Functional Analysis of Plasmodium Protein Phosphatases Reveals Key Regulators of Parasite Development and Differentiation (2014)
Journal Article
Guttery, D. S., TEWARI, R., Poulin, B., Ramaprasad, A., Wall, R. J., Ferguson, D. J., …Pain, A. (2014). Genome-wide Functional Analysis of Plasmodium Protein Phosphatases Reveals Key Regulators of Parasite Development and Differentiation. Cell Host and Microbe, 16(1), 128-140. https://doi.org/10.1016/j.chom.2014.05.020

Reversible protein phosphorylation regulated by kinases and phosphatases controls many cellular processes. Although essential functions for the malaria parasite kinome have been reported, the roles of most protein phosphatases (PPs) during Plasmodium... Read More about Genome-wide Functional Analysis of Plasmodium Protein Phosphatases Reveals Key Regulators of Parasite Development and Differentiation.

Molecular Mechanisms of Bitopic Ligand Engagement with the M1 Muscarinic Acetylcholine Receptor (2014)
Journal Article
Keov, P., Lopez, L., Devine, S. M., Valant, C., Lane, J. R., Scammells, P. J., …Christopoulos, A. (2014). Molecular Mechanisms of Bitopic Ligand Engagement with the M1 Muscarinic Acetylcholine Receptor. Journal of Biological Chemistry, 289(34), 23817-23837. https://doi.org/10.1074/jbc.M114.582874

TBPB and 77-LH-28-1 are selective agonists of the M1 muscarinic acetylcholine receptor (mAChR) that may gain their selectivity through a bitopic mechanism, interacting concomitantly with the orthosteric site and part of an allosteric site. The curren... Read More about Molecular Mechanisms of Bitopic Ligand Engagement with the M1 Muscarinic Acetylcholine Receptor.

The Effects of Conformational Constraints in the Polyamine Moiety of Philanthotoxins on AMPAR Inhibition (2014)
Journal Article
Franzyk, H., Grzeskowiak, J. W., Tikhonov, D. B., Jaroszewski, J. W., & Mellor, I. R. (2014). The Effects of Conformational Constraints in the Polyamine Moiety of Philanthotoxins on AMPAR Inhibition. ChemMedChem, 9(8), 1725-1731. https://doi.org/10.1002/cmdc.201402109

Philanthotoxin?433 (PhTX?433) is a known potent inhibitor of ionotropic glutamate receptors, and analogues have been synthesised to identify more potent and selective antagonists. Herein we report the synthesis of four PhTXs with a cyclopropane moiet... Read More about The Effects of Conformational Constraints in the Polyamine Moiety of Philanthotoxins on AMPAR Inhibition.

An Immunological Marker of Tolerance to Infection in Wild Rodents (2014)
Journal Article
Jackson, J. A., Hall, A. J., Friberg, I. M., Ralli, C., Lowe, A., Zawadzka, M., …Begon, M. (2014). An Immunological Marker of Tolerance to Infection in Wild Rodents. PLoS Biology, 12(7), Article e1001901. https://doi.org/10.1371/journal.pbio.1001901

Hosts are likely to respond to parasitic infections by a combination of resistance (expulsion of pathogens) and tolerance (active mitigation of pathology). Of these strategies, the basis of tolerance in animal hosts is relatively poorly understood, w... Read More about An Immunological Marker of Tolerance to Infection in Wild Rodents.

Expression of Arginase I in Myeloid Cells Limits Control of Residual Disease after Radiation Therapy of Tumors in Mice (2014)
Journal Article
Crittenden, M. R., Savage, T., Cottam, B., Baird, J., Rodriguez, P. C., Newell, P., …Gough, M. J. (2014). Expression of Arginase I in Myeloid Cells Limits Control of Residual Disease after Radiation Therapy of Tumors in Mice. Radiation Research, 182(2), 182-190. https://doi.org/10.1667/rr13493.1

An accumulating body of evidence demonstrates that radiation therapy can generate adaptive immune responses that contribute to tumor control. However, in the absence of additional immune therapy, the adaptive immune response is insufficient to preven... Read More about Expression of Arginase I in Myeloid Cells Limits Control of Residual Disease after Radiation Therapy of Tumors in Mice.

Effect of fructose and sucralose on flow-mediated vasodilatation in healthy, white European males (2014)
Journal Article
Memon, M. Q., Simpson, E. J., & Macdonald, I. A. (2014). Effect of fructose and sucralose on flow-mediated vasodilatation in healthy, white European males. Journal- Pakistan Medical Association, 64(7), 743-747

Objective: To assess how acute consumption of fructose affects flow-mediated dilatation in brachial artery. Methods: The randomised cross-over study was conducted at the University of Nottingham's Medical School, Nottingham, United Kingdom in July 20... Read More about Effect of fructose and sucralose on flow-mediated vasodilatation in healthy, white European males.

Erratum: Genes involved in the induction of liver growth by peroxisome proliferators (Toxicol. Res. (2014) DOI: 10.1039/c3tx50110h) (2014)
Journal Article
Amer, A. H., Wall, R. J., Malla, S., Aboobaker, A., Sang, F., Avery, S. V., …Bell, D. R. (2014). Erratum: Genes involved in the induction of liver growth by peroxisome proliferators (Toxicol. Res. (2014) DOI: 10.1039/c3tx50110h). Toxicology Research, 3(5), 401. https://doi.org/10.1039/C4TX90012J

The authors would like to add an additional acknowledgement as follows: We wish to acknowledge Fikry Abushofa for technical assistance.

Identification of Angiostrongylus cantonensis and other nematodes using the SSU rDNA in Achatina fulica populations of Metro Manila (2014)
Journal Article
Constantino-Santos, D. M., Basiao, Z. U., Wade, C. M., Santos, B. S., & Fontanilla, I. K. (2014). Identification of Angiostrongylus cantonensis and other nematodes using the SSU rDNA in Achatina fulica populations of Metro Manila. Tropical Biomedicine, 31(2), 327-335

Angiostrongylus cantonensis is a parasitic nematode that causes eosinophilic meningitis in humans. Accidental infection occurs by consumption of contaminated intermediates, such as the giant African land snail, Achatina fulica. This study surveyed th... Read More about Identification of Angiostrongylus cantonensis and other nematodes using the SSU rDNA in Achatina fulica populations of Metro Manila.