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Computational modeling of the effects of auditory nerve dysmyelination

Brown, Angus M.; Hamann, Martine

Authors

Martine Hamann



Abstract

Our previous study showed that exposure to loud sound leading to hearing loss elongated the auditory nerve (AN) nodes of Ranvier and triggered notable morphological changes at paranodes and juxtaparanodes. Here we used computational modeling to examine how theoretical redistribution of voltage gated Na+, Kv3.1, and Kv1.1 channels along the AN may be responsible for the alterations of conduction property following acoustic over-exposure. Our modeling study infers that changes related to Na+ channel density (rather than the redistribution of voltage gated Na+, Kv3.1, and Kv1.1 channels) is the likely cause of the decreased conduction velocity and the conduction block observed after acoustic overexposure (AOE).

Citation

Brown, A. M., & Hamann, M. (2014). Computational modeling of the effects of auditory nerve dysmyelination. Frontiers in Neuroanatomy, 8(73), https://doi.org/10.3389/fnana.2014.00073

Journal Article Type Article
Acceptance Date Jul 12, 2014
Online Publication Date Aug 1, 2014
Publication Date Aug 1, 2014
Deposit Date Jul 25, 2016
Publicly Available Date Jul 25, 2016
Journal Frontiers in Neuroanatomy
Electronic ISSN 1662-5129
Publisher Frontiers Media
Peer Reviewed Peer Reviewed
Volume 8
Issue 73
DOI https://doi.org/10.3389/fnana.2014.00073
Keywords myelin sheath, hearing loss, node of Ranvier, conduction velocity, conduction block, deafness, myelin domains, action potential
Public URL http://eprints.nottingham.ac.uk/id/eprint/35377
Publisher URL http://journal.frontiersin.org/article/10.3389/fnana.2014.00073/full
Copyright Statement Copyright information regarding this work can be found at the following address: http://creativecommons.org/licenses/by/4.0
Additional Information This Document is Protected by copyright and was first published by Frontiers. All rights reserved. It is reproduced with permission.

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