Dr ANGUS BROWN A.M.BROWN@NOTTINGHAM.AC.UK
ASSOCIATE PROFESSOR
Computational modeling of the effects of auditory nerve dysmyelination
Brown, Angus M.; Hamann, Martine
Authors
Martine Hamann
Abstract
Our previous study showed that exposure to loud sound leading to hearing loss elongated the auditory nerve (AN) nodes of Ranvier and triggered notable morphological changes at paranodes and juxtaparanodes. Here we used computational modeling to examine how theoretical redistribution of voltage gated Na+, Kv3.1, and Kv1.1 channels along the AN may be responsible for the alterations of conduction property following acoustic over-exposure. Our modeling study infers that changes related to Na+ channel density (rather than the redistribution of voltage gated Na+, Kv3.1, and Kv1.1 channels) is the likely cause of the decreased conduction velocity and the conduction block observed after acoustic overexposure (AOE).
Citation
Brown, A. M., & Hamann, M. (2014). Computational modeling of the effects of auditory nerve dysmyelination. Frontiers in Neuroanatomy, 8(73), https://doi.org/10.3389/fnana.2014.00073
| Journal Article Type | Article |
|---|---|
| Acceptance Date | Jul 12, 2014 |
| Online Publication Date | Aug 1, 2014 |
| Publication Date | Aug 1, 2014 |
| Deposit Date | Jul 25, 2016 |
| Publicly Available Date | Jul 25, 2016 |
| Journal | Frontiers in Neuroanatomy |
| Electronic ISSN | 1662-5129 |
| Publisher | Frontiers Media |
| Peer Reviewed | Peer Reviewed |
| Volume | 8 |
| Issue | 73 |
| DOI | https://doi.org/10.3389/fnana.2014.00073 |
| Keywords | myelin sheath, hearing loss, node of Ranvier, conduction velocity, conduction block, deafness, myelin domains, action potential |
| Public URL | https://nottingham-repository.worktribe.com/output/731287 |
| Publisher URL | http://journal.frontiersin.org/article/10.3389/fnana.2014.00073/full |
| Additional Information | This Document is Protected by copyright and was first published by Frontiers. All rights reserved. It is reproduced with permission. |
| Contract Date | Jul 25, 2016 |
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Publisher Licence URL
https://creativecommons.org/licenses/by/4.0/
Copyright Statement
Copyright information regarding this work can be found at the following address: http://creativecommons.org/licenses/by/4.0
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