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A role for the sodium pump in H2O2-induced vasorelaxation in porcine isolated coronary arteries (2014)
Journal Article
Wong, P., Garle, M., Alexander, S., Randall, M., & Roberts, R. (2014). A role for the sodium pump in H2O2-induced vasorelaxation in porcine isolated coronary arteries. Pharmacological Research, 90, https://doi.org/10.1016/j.phrs.2014.09.004

Hydrogen peroxide (H2O2) has been proposed to act as a factor for endothelium-derived hyperpolar-ization (EDH) and EDH may act as a ‘back up’ system to compensate the loss of the NO pathway. Here,the mechanism of action of H2O2in porcine isolated cor... Read More about A role for the sodium pump in H2O2-induced vasorelaxation in porcine isolated coronary arteries.

Development of ten microsatellite loci in the invasive giant African land snail, Achatina (=Lissachatina) fulica Bowdich, 1822 (2014)
Journal Article
Morrison, C. L., Springmann, M. J., Iwanowicz, D. D., & Wade, C. M. (2015). Development of ten microsatellite loci in the invasive giant African land snail, Achatina (=Lissachatina) fulica Bowdich, 1822. Conservation Genetics Resources, 7(1), 201-202. https://doi.org/10.1007/s12686-014-0332-3

© 2014, Springer Science+Business Media Dordrecht (outside the USA). A suite of tetra-nucleotide microsatellite loci were developed for the invasive giant African land snail, Achatina (=Lissachatina) fulica Bowdich, 1822, from Ion Torrent next-genera... Read More about Development of ten microsatellite loci in the invasive giant African land snail, Achatina (=Lissachatina) fulica Bowdich, 1822.

Raised tone reveals ATP as a sympathetic neurotransmitter in the porcine mesenteric arterial bed (2014)
Journal Article
Shatarat, A., Dunn, W. R., & Ralevic, V. (in press). Raised tone reveals ATP as a sympathetic neurotransmitter in the porcine mesenteric arterial bed. Purinergic Signalling, 10(4), https://doi.org/10.1007/s11302-014-9426-3

The relative importance of ATP as a functional sympathetic neurotransmitter in blood vessels has been shown to be increased when the level of preexisting vascular tone or pressure is increased, in studies carried out in rat mesenteric arteries. The a... Read More about Raised tone reveals ATP as a sympathetic neurotransmitter in the porcine mesenteric arterial bed.

Drosophila heart cell movement to the midline occurs through both cell autonomous migration and dorsal closure (2014)
Journal Article
Haack, T., Schneider, M., Schwendele, B., & Renault, A. D. (2014). Drosophila heart cell movement to the midline occurs through both cell autonomous migration and dorsal closure. Developmental Biology, 396(2), https://doi.org/10.1016/j.ydbio.2014.08.033

The Drosophila heart is a linear organ formed by the movement of bilaterally specified progenitor cells to the midline and adherence of contralateral heart cells. This movement occurs through the attachment of heart cells to the overlying ectoderm wh... Read More about Drosophila heart cell movement to the midline occurs through both cell autonomous migration and dorsal closure.

Restricted Genetic Variation in Populations of Achatina (Lissachatina) fulica outside of East Africa and the Indian Ocean Islands Points to the Indian Ocean Islands as the Earliest Known Common Source (2014)
Journal Article
Fontanilla, I. K. C., Sta. Maria, I. M. P., Garcia, J. R. M., Ghate, H., Naggs, F., & Wade, C. (2014). Restricted Genetic Variation in Populations of Achatina (Lissachatina) fulica outside of East Africa and the Indian Ocean Islands Points to the Indian Ocean Islands as the Earliest Known Common Source. PLoS ONE, 9(9), Article e105151. https://doi.org/10.1371/journal.pone.0105151

The Giant African Land Snail, Achatina (?=?Lissachatina) fulica Bowdich, 1822, is a tropical crop pest species with a widespread distribution across East Africa, the Indian subcontinent, Southeast Asia, the Pacific, the Caribbean, and North and South... Read More about Restricted Genetic Variation in Populations of Achatina (Lissachatina) fulica outside of East Africa and the Indian Ocean Islands Points to the Indian Ocean Islands as the Earliest Known Common Source.

Fish oil omega-3 fatty acids partially prevent lipid-induced insulin resistance in human skeletal muscle without limiting acylcarnitine accumulation (2014)
Journal Article
Stephens, F. B., Mendis, B., Shannon, C. E., Cooper, S., Ortori, C. A., Barrett, D. A., …Tsintzas, K. (2014). Fish oil omega-3 fatty acids partially prevent lipid-induced insulin resistance in human skeletal muscle without limiting acylcarnitine accumulation. Clinical Science, 127(5), 315-322. https://doi.org/10.1042/cs20140031

Acylcarnitine accumulation in skeletal muscle and plasma has been observed in numerous models of mitochondrial lipid overload and insulin resistance. Fish oil n3PUFA (omega-3 polyunsaturated fatty acids) are thought to protect against lipid-induced i... Read More about Fish oil omega-3 fatty acids partially prevent lipid-induced insulin resistance in human skeletal muscle without limiting acylcarnitine accumulation.

Crystal structure of the antimicrobial peptidase lysostaphin from Staphylococcus simulans (2014)
Journal Article
Sabala, I., Jagielska, E., Bardelang, P. T., Czapinska, H., Dahms, S. O., Sharpe, J. A., …Bochtler, M. (2014). Crystal structure of the antimicrobial peptidase lysostaphin from Staphylococcus simulans. FEBS Journal, 281(18), 4112-4122. https://doi.org/10.1111/febs.12929

Staphylococcus simulansbiovarstaphylolyticuslysostaphin efficiently cleavesStaphylococcus aureuscell walls. The protein is in late clinical trials as atopical anti-staphylococcal agent, and can be used to prevent staphylococcalgrowth on artificial su... Read More about Crystal structure of the antimicrobial peptidase lysostaphin from Staphylococcus simulans.

MicroRNAs and p63 in epithelial stemness (2014)
Journal Article
Candi, E., Amelio, I., Agostini, M., & Melino, G. (2015). MicroRNAs and p63 in epithelial stemness. Cell Death and Differentiation, 22(1), 12-21. https://doi.org/10.1038/cdd.2014.113

MicroRNAs (miRs) are a class of small noncoding RNAs that suppress the expression of protein-coding genes by repressing protein translation. Although the roles that miRs and the miR processing machinery have in regulating epithelial stem cell biology... Read More about MicroRNAs and p63 in epithelial stemness.

Evolution of sweet taste perception in hummingbirds by transformation of the ancestral umami receptor (2014)
Journal Article
Baldwin, M. W., Toda, Y., Nakagita, T., O'Connell, M. J., Klasing, K. C., Misaka, T., …Liberles, S. D. (2014). Evolution of sweet taste perception in hummingbirds by transformation of the ancestral umami receptor. Science, 345(6199), 929-933. https://doi.org/10.1126/science.1255097

Sensory systems define an animal's capacity for perception and can evolve to promote survival in new environmental niches. We have uncovered a noncanonical mechanism for sweet taste perception that evolved in hummingbirds since their divergence from... Read More about Evolution of sweet taste perception in hummingbirds by transformation of the ancestral umami receptor.

Regulation of alternative VEGF-A mRNA splicing is a therapeutic target for analgesia (2014)
Journal Article
Hulse, R., Beazley-Long, N., Hua, J., Kennedy, H., Prager, J., Bevan, H., …Donaldson, L. (2014). Regulation of alternative VEGF-A mRNA splicing is a therapeutic target for analgesia. Neurobiology of Disease, 71, 245-259. https://doi.org/10.1016/j.nbd.2014.08.012

Vascular endothelial growth factor-A (VEGF-A) is best known as a key regulator of the formation of new blood vessels. Neutralization of VEGF-A with anti-VEGF therapy e.g. bevacizumab, can be painful, and this is hypothesized to result from a loss of... Read More about Regulation of alternative VEGF-A mRNA splicing is a therapeutic target for analgesia.

Female-limited colour polymorphism in the crab spider Synema globosum (Araneae: Thomisidae) (2014)
Journal Article
Ajuria Ibarra, H., & Reader, T. (2014). Female-limited colour polymorphism in the crab spider Synema globosum (Araneae: Thomisidae). Biological Journal of the Linnean Society, 113(2), https://doi.org/10.1111/bij.12338

Conspicuous colour variation, caused by the influence of the environment on phenotype, or by genetic differences among individuals, is frequently observed in nature. If genetic in origin, colour variation can facilitate the study of the mechanisms th... Read More about Female-limited colour polymorphism in the crab spider Synema globosum (Araneae: Thomisidae).

Multidomain Hybrid Hydrogels: Spatially Resolved Photopatterned Synthetic Nanomaterials Combining Polymer and Low‐Molecular‐Weight Gelators (2014)
Journal Article
Cornwell, D. J., Okesola, B. O., & Smith, D. K. (2014). Multidomain Hybrid Hydrogels: Spatially Resolved Photopatterned Synthetic Nanomaterials Combining Polymer and Low‐Molecular‐Weight Gelators. Angewandte Chemie, 126(46), 12669-12673. https://doi.org/10.1002/ange.201405098

A simple approach to a patterned multidomain gel is reported, combining a pH-responsive low-molecular-weight gelator (LMWG) and a photoinducible polymer gelator (PG). Using SEM (scanning electron microscopy), NMR spectroscopy, and CD, we demonstrate... Read More about Multidomain Hybrid Hydrogels: Spatially Resolved Photopatterned Synthetic Nanomaterials Combining Polymer and Low‐Molecular‐Weight Gelators.

Culturally valuable minority crops provide a succession of floral resources for flower visitors in traditional orchard gardens (2014)
Journal Article
Norfolk, O., Eichhorn, M. P., & Gilbert, F. (2014). Culturally valuable minority crops provide a succession of floral resources for flower visitors in traditional orchard gardens. Biodiversity and Conservation, 23(13), 3199-3217. https://doi.org/10.1007/s10531-014-0775-6

Agricultural intensification typically has detrimental effects on pollinator communities, but diverse cropping systems that contain sequentially-flowering crops have the potential to benefit pollinators through the provision of additional floral reso... Read More about Culturally valuable minority crops provide a succession of floral resources for flower visitors in traditional orchard gardens.

Adverse effects of antipsychotics on micro-vascular endothelial cells of the human blood-brain barrier (2014)
Journal Article
Elmorsy, E., Elzalabany, L. M., Elsheikha, H. M., & Smith, P. A. (2014). Adverse effects of antipsychotics on micro-vascular endothelial cells of the human blood-brain barrier. Brain Research, 1583(1), 255-268. https://doi.org/10.1016/j.brainres.2014.08.011

© 2014 Elsevier B.V. All rights reserved. Although the mechanisms of action of antipsychotics (APs) on neuronal function are well understood, very little is known about their effects on cells of the blood-brain barrier (BBB); one function of which is... Read More about Adverse effects of antipsychotics on micro-vascular endothelial cells of the human blood-brain barrier.

CX3CL1 is up-regulated in the rat hippocampus during memory-associated synaptic plasticity (2014)
Journal Article
Sheridan, G. K., Wdowicz, A., Pickering, M., Watters, O., Halley, P., O'Sullivan, N. C., …Murphy, K. J. (2014). CX3CL1 is up-regulated in the rat hippocampus during memory-associated synaptic plasticity. Frontiers in Cellular Neuroscience, 8, Article 233. https://doi.org/10.3389/fncel.2014.00233

Several cytokines and chemokines are now known to play normal physiological roles in the brain where they act as key regulators of communication between neurons, glia, and microglia. In particular, cytokines and chemokines can affect cardinal cellula... Read More about CX3CL1 is up-regulated in the rat hippocampus during memory-associated synaptic plasticity.

A new mechanism of allostery in a G protein-coupled receptor dimer (2014)
Journal Article
Lane, J. R., Donthamsetti, P., Shonberg, J., Draper-Joyce, C. J., Dentry, S., Michino, M., …Christopoulos, A. (2014). A new mechanism of allostery in a G protein-coupled receptor dimer. Nature Chemical Biology, 10(9), 745-752. https://doi.org/10.1038/nchembio.1593

SB269652 is to our knowledge the first drug-like allosteric modulator of the dopamine D2 receptor (D2R), but it contains structural features associated with orthosteric D2R antagonists. Using a functional complementation system to control the identit... Read More about A new mechanism of allostery in a G protein-coupled receptor dimer.

Sexual reproduction of human fungal pathogens (2014)
Journal Article
Heitman, J., Carter, D. A., Dyer, P. S., & Soll, D. R. (in press). Sexual reproduction of human fungal pathogens. Cold Spring Harbor Perspectives in Medicine, 4(8), Article a019281. https://doi.org/10.1101/cshperspect.a019281

We review here recent advances in our understanding of sexual reproduction in fungal pathogens that commonly infect humans, including Candida albicans, Cryptococcus neoformans/gattii, and Aspergillus fumigatus. Where appropriate or relevant, we intro... Read More about Sexual reproduction of human fungal pathogens.