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Cardiac troponin T is necessary for normal development in the embryonic chick heart (2016)
Journal Article
England, J., Pang, K. L., Parnall, M., Haig, M. I., & Loughna, S. (in press). Cardiac troponin T is necessary for normal development in the embryonic chick heart. Journal of Anatomy, https://doi.org/10.1111/joa.12486

The heart is the first functioning organ to develop during embryogenesis. The formation of the heart is a tightly regulated and complex process, and alterations to its development can result in congenital heart defects. Mutations in sarcomeric protei... Read More about Cardiac troponin T is necessary for normal development in the embryonic chick heart.

The anti-NGF antibody muMab 911 both prevents and reverses pain behaviour and subchondral osteoclast numbers in a rat model of osteoarthritis pain (2016)
Journal Article
Xu, L., Nwosu, L. N., Burston, J., Millns, P., Sagar, D. R., Mapp, P. I., …Chapman, V. (2016). The anti-NGF antibody muMab 911 both prevents and reverses pain behaviour and subchondral osteoclast numbers in a rat model of osteoarthritis pain. Osteoarthritis and Cartilage, 24(9), 1587-1595. https://doi.org/10.1016/j.joca.2016.05.015

Objective: Nerve growth factor (NGF) has a pivotal role in peripheral hyperalgesia and inflammation; anti-NGF antibodies attenuate pain responses in inflammatory pain models, and in people with osteoarthritis (OA) or low back pain. The aim of this st... Read More about The anti-NGF antibody muMab 911 both prevents and reverses pain behaviour and subchondral osteoclast numbers in a rat model of osteoarthritis pain.

Immunomodulation with self-crosslinked polyelectrolyte multilayer-based coatings (2016)
Journal Article
Knopf-Marques, H., Singh, S., Htwe, S. S., Wolfova, L., Buffa, R., Bacharouche, J., …Lavalle, P. (2016). Immunomodulation with self-crosslinked polyelectrolyte multilayer-based coatings. Biomacromolecules, 17(6), 2189-2198. https://doi.org/10.1021/acs.biomac.6b00429

This study aims to design an optimal polyelectrolyte multilayer film of poly-L-lysine (PLL) and hyaluronic acid(HA) as an anti-inflammatory cytokine release system in order to decrease the implant failure due to any immune reactions. The chemical mod... Read More about Immunomodulation with self-crosslinked polyelectrolyte multilayer-based coatings.

Impaired burrowing is the most prominent behavioral deficit of aging htau mice (2016)
Journal Article
Geiszler, P. C., Barron, M., & Pardon, M. (in press). Impaired burrowing is the most prominent behavioral deficit of aging htau mice. Neuroscience, https://doi.org/10.1016/j.neuroscience.2016.05.004

htau mice are deficient of murine tau but express all six human tau isoforms, leading to gradual tau misprocessing and aggregation in brain areas relevant to Alzheimer's disease. Whilst histopathological changes in htau mice have been researched in t... Read More about Impaired burrowing is the most prominent behavioral deficit of aging htau mice.

Non-parametric directionality analysis: extension for removal of a single common predictor and application to time series (2016)
Journal Article
Halliday, D. M., Senik, M. H., Stevenson, C. W., & Mason, R. (2016). Non-parametric directionality analysis: extension for removal of a single common predictor and application to time series. Journal of Neuroscience Methods, 268, https://doi.org/10.1016/j.jneumeth.2016.05.008

BACKGROUND: The ability to infer network structure from multivariate neuronal signals is central to computational neuroscience. Directed network analyses typically use parametric approaches based on auto-regressive (AR) models, where networks are con... Read More about Non-parametric directionality analysis: extension for removal of a single common predictor and application to time series.

Multivariable regression analysis in Schistosoma mansoni-infected individuals in the Sudan reveals unique immunoepidemiological profiles in uninfected, egg+ and non-egg+ infected individuals (2016)
Journal Article
Elfaki, T. E. M., Arndts, K., Wiszniewsky, A., Ritter, M., Goreish, I. A., Atti El Mekki, M. E. Y. A., …Layland, L. E. (2016). Multivariable regression analysis in Schistosoma mansoni-infected individuals in the Sudan reveals unique immunoepidemiological profiles in uninfected, egg+ and non-egg+ infected individuals. PLoS Neglected Tropical Diseases, 10(5), Article e0004629. https://doi.org/10.1371/journal.pntd.0004629

Background: In the Sudan, Schistosoma mansoni infections are a major cause of morbidity in schoolaged children and infection rates are associated with available clean water sources. During infection, immune responses pass through a Th1 followed by Th... Read More about Multivariable regression analysis in Schistosoma mansoni-infected individuals in the Sudan reveals unique immunoepidemiological profiles in uninfected, egg+ and non-egg+ infected individuals.

The association between prior statin use and long-term outcomes after critical care admission (2016)
Journal Article
Beed, M., Brindley, P., Mahajan, R., Juttner, I., Campion-Smith, J., & Wilson, V. (2016). The association between prior statin use and long-term outcomes after critical care admission. Journal of Critical Care, 35, 63-68. https://doi.org/10.1016/j.jcrc.2016.04.031

Background: Statins may have immunomodulatory effects that benefit critically ill patients. Therefore we retrospectively examined the association between survival and the prescription of statins prior to admission to an intensive care unit (ICU), or... Read More about The association between prior statin use and long-term outcomes after critical care admission.

Vascular ageing and endothelial cell senescence: Molecular mechanisms of physiology and diseases (2016)
Journal Article
Regina, C., Panatta, E., Candi, E., Melino, G., Amelio, I., Balistreri, C. R., …Ruvolo, G. (2016). Vascular ageing and endothelial cell senescence: Molecular mechanisms of physiology and diseases. Mechanisms of Ageing and Development, 159, 14-21. https://doi.org/10.1016/j.mad.2016.05.003

Ageing leads to a progressive deterioration of structure and function of all organs over the time. During this process endothelial cells undergo senescence and manifest significant changes in their properties, resulting in impairment of the vascular... Read More about Vascular ageing and endothelial cell senescence: Molecular mechanisms of physiology and diseases.

Fevipiprant (QAW039), a slowly dissociating CRTh2 antagonist with the potential for improved clinical efficacy (2016)
Journal Article
Sykes, D. A., Bradley, M. E., Riddy, D. M., Willard, E., Reilly, J., Miah, A., …Charlton, S. J. (2016). Fevipiprant (QAW039), a slowly dissociating CRTh2 antagonist with the potential for improved clinical efficacy. Molecular Pharmacology, 89(5), 593-605. https://doi.org/10.1124/mol.115.101832

Here we describe the pharmacologic properties of a series of clinically relevant chemoattractant receptor-homologous molecules expressed on T-helper type 2 (CRTh2) receptor antagonists, including fevipiprant (NVP-QAW039 or QAW039), which is currently... Read More about Fevipiprant (QAW039), a slowly dissociating CRTh2 antagonist with the potential for improved clinical efficacy.

“Every gene is everywhere but the environment selects”: Global geolocalization of gene sharing in environmental samples through network analysis (2016)
Journal Article
Fondi, M., Karkman, A., Tamminen, M. V., Bosi, E., Virta, M., Fani, R., …McInerney, J. O. (2016). “Every gene is everywhere but the environment selects”: Global geolocalization of gene sharing in environmental samples through network analysis. Genome Biology and Evolution, 8(5), 1388-1400. https://doi.org/10.1093/gbe/evw077

© The Author(s) 2016. The spatial distribution of microbes on our planet is famously formulated in the Baas Becking hypothesis as “everything is everywhere but the environment selects.” While this hypothesis does not strictly rule out patterns caused... Read More about “Every gene is everywhere but the environment selects”: Global geolocalization of gene sharing in environmental samples through network analysis.

Neuron-immune mechanisms contribute to pain in early stages of arthritis (2016)
Journal Article
Nieto, F. R., Clark, A. K., Grist, J., Hathway, G. J., Chapman, V., & Malcangio, M. (2016). Neuron-immune mechanisms contribute to pain in early stages of arthritis. Journal of Neuroinflammation, 13, https://doi.org/10.1186/s12974-016-0556-0

Background: Rheumatoid arthritis (RA) patients frequently show weak correlations between the magnitude of pain and inflammation suggesting that mechanisms other than overt peripheral inflammation contribute to pain in RA. We assessed changes in micro... Read More about Neuron-immune mechanisms contribute to pain in early stages of arthritis.

Engineering Immunomodulatory Biomaterials To Tune the Inflammatory Response (2016)
Journal Article
Vishwakarma, A., Bhise, N. S., Evangelista, M. B., Rouwkema, J., Dokmeci, M. R., Ghaemmaghami, A. M., …Khademhosseini, A. (2016). Engineering Immunomodulatory Biomaterials To Tune the Inflammatory Response. Trends in Biotechnology, 34(6), 470-482. https://doi.org/10.1016/j.tibtech.2016.03.009

Current state-of-the-art biomedical implants and tissue engineering methods promise technologies to improve or even restore the function of diseased organs. However, one of the biggest challenges to clinical success is the lack of functional integrat... Read More about Engineering Immunomodulatory Biomaterials To Tune the Inflammatory Response.

A non-canonical melanin biosynthesis pathway protects Aspergillus terreus conidia from environmental stress (2016)
Journal Article
Geib, E., Gressler, M., Viediernikova, I., Hillmann, F., Jacobsen, I. D., Nietzsche, S., …Brock, M. (2016). A non-canonical melanin biosynthesis pathway protects Aspergillus terreus conidia from environmental stress. Cell Chemical Biology, 23(5), https://doi.org/10.1016/j.chembiol.2016.03.014

Pro- and eukaryotes produce melanin for protection from environmental stress or as virulence determinant. The human pathogenic fungus Aspergillus fumigatus and related Ascomycetes produce dihydroxynaphthalene (DHN) melanin in conidia, which is essent... Read More about A non-canonical melanin biosynthesis pathway protects Aspergillus terreus conidia from environmental stress.

Glutathione reductase gsr-1 is an essential gene required for Caenorhabditis elegans early embryonic development (2016)
Journal Article
Mora-Lorca, J. A., Sáenz-Narciso, B., Gaffney, C. J., Naranjo-Galindo, F. J., Pedrajas, J. R., Guerrero-Gómez, D., …Miranda-Vizuete, A. (in press). Glutathione reductase gsr-1 is an essential gene required for Caenorhabditis elegans early embryonic development. Free Radical Biology and Medicine, 96, https://doi.org/10.1016/j.freeradbiomed.2016.04.017

Glutathione is the most abundant thiol in the vast majority of organisms and is maintained in its reduced form by the flavoenzyme glutathione reductase. In this work, we describe the genetic and functional analysis of the Caenorhabditis elegans gsr-1... Read More about Glutathione reductase gsr-1 is an essential gene required for Caenorhabditis elegans early embryonic development.

A protease-based biosensor for the detection of schistosome cercariae (2016)
Journal Article
Webb, A., Kelwick, R., Doenhoff, M., Kylilis, N., MacDonald, J., Wen, K., …Freemont, P. (2016). A protease-based biosensor for the detection of schistosome cercariae. Scientific Reports, 6, Article 24725. https://doi.org/10.1038/srep24725

Parasitic diseases affect millions of people worldwide, causing debilitating illnesses and death. Rapid and cost-effective approaches to detect parasites are needed, especially in resource-limited settings. A common signature of parasitic diseases is... Read More about A protease-based biosensor for the detection of schistosome cercariae.

Infection-mediated priming of phagocytes protects against lethal secondary Aspergillus fumigatus challenge (2016)
Journal Article
Savers, A., Rasid, O., Parlato, M., Brock, M., Jouvion, G., Ryffel, B., …Ibrahim-Granet, O. (2016). Infection-mediated priming of phagocytes protects against lethal secondary Aspergillus fumigatus challenge. PLoS ONE, 11(4), Article e0153829. https://doi.org/10.1371/journal.pone.0153829

Phagocytes restrict the germination of Aspergillus fumigatus conidia and prevent the establishment of invasive pulmonary aspergillosis in immunecompetent mice. Here we report that immunecompetent mice recovering from a primary A. fumigatus challenge... Read More about Infection-mediated priming of phagocytes protects against lethal secondary Aspergillus fumigatus challenge.

Labeling of mesenchymal stem cells for MRI with single-cell sensitivity (2016)
Journal Article
Ariza de Schellenberger, A., Kratz, H., Farr, T. D., Löewa, N., Hauptmann, R., Wagner, S., …Schellenberger, E. A. (2016). Labeling of mesenchymal stem cells for MRI with single-cell sensitivity. International Journal of Nanomedicine, 11, 1517-1535. https://doi.org/10.2147/IJN.S101141

Sensitive cell detection by magnetic resonance imaging (MRI) is an important tool for the development of cell therapies. However, clinically approved contrast agents that allow single-cell detection are currently not available. Therefore, we compared... Read More about Labeling of mesenchymal stem cells for MRI with single-cell sensitivity.

Neural correlates of hyperalgesia in the monosodium iodoacetate model of osteoarthritis pain (2016)
Journal Article
Abaei, M., Sagar, D. R., Stockley, E. G., Spicer, C. H., Prior, M., Chapman, V., & Auer, D. P. (in press). Neural correlates of hyperalgesia in the monosodium iodoacetate model of osteoarthritis pain. Molecular Pain, 12, https://doi.org/10.1177/1744806916642445

Background: The mechanisms driving osteoarthritic pain remain poorly understood, but there is increasing evidence for a role of the central nervous system in the chronification of pain.We used functional magnetic resonance imaging to investigate the... Read More about Neural correlates of hyperalgesia in the monosodium iodoacetate model of osteoarthritis pain.

The use of fluorescence correlation spectroscopy to characterize the molecular mobility of fluorescently labelled G protein-coupled receptors (2016)
Journal Article
Kilpatrick, L. E., & Hill, S. J. (in press). The use of fluorescence correlation spectroscopy to characterize the molecular mobility of fluorescently labelled G protein-coupled receptors. Biochemical Society Transactions, 44(2), https://doi.org/10.1042/BST20150285

The membranes of living cells have been shown to be highly organized into distinct microdomains, which has spatial and temporal consequences for the interaction of membrane bound receptors and their signalling partners as complexes. Fluorescence corr... Read More about The use of fluorescence correlation spectroscopy to characterize the molecular mobility of fluorescently labelled G protein-coupled receptors.