Helena Knopf-Marques
Immunomodulation with self-crosslinked polyelectrolyte multilayer-based coatings
Knopf-Marques, Helena; Singh, Sonali; Htwe, Su Su; Wolfova, Lucie; Buffa, Radovan; Bacharouche, Jalal; Francius, Gre?gory; Voegel, Jean-Claude; Schaaf, Pierre; Ghaemmaghami, Amir M.; Vrana, Nihal E.; Lavalle, Philippe
Authors
SONALI SINGH SONALI.SINGH@NOTTINGHAM.AC.UK
Research Development Manager
Su Su Htwe
Lucie Wolfova
Radovan Buffa
Jalal Bacharouche
Gre?gory Francius
Jean-Claude Voegel
Pierre Schaaf
Professor AMIR GHAEMMAGHAMI AMIR.GHAEMMAGHAMI@NOTTINGHAM.AC.UK
Professor of Immunology and Immuno- Bioengineering
Nihal E. Vrana
Philippe Lavalle
Abstract
This study aims to design an optimal polyelectrolyte multilayer film of poly-L-lysine (PLL) and hyaluronic acid(HA) as an anti-inflammatory cytokine release system in order to decrease the implant failure due to any immune reactions. The chemical modification of the HA with aldehyde moieties allows self-cross-linking of the film and an improvement in the mechanical properties of the film. The cross-linking of the film and the release of immunomodulatory cytokine (IL-4) stimulate the differentiation of primary human monocytes seeded on the films into pro-healing macrophages phenotype. This induces the production of antiinflammatory cytokines (IL1-RA and CCL18) and the decrease of proinflammatory cytokines secreted (IL-12, TNF-α, and IL-1β). Moreover, we demonstrate that cross-linking PLL/HA film using HA-aldehyde is already effective by itself to limit inflammatory processes. Finally, this functionalized self-cross-linked PLL/HA-aldehyde films constitutes an innovative and efficient candidate for immunomodulation of any kind of implants of various architecture and properties.
Citation
Knopf-Marques, H., Singh, S., Htwe, S. S., Wolfova, L., Buffa, R., Bacharouche, J., …Lavalle, P. (2016). Immunomodulation with self-crosslinked polyelectrolyte multilayer-based coatings. Biomacromolecules, 17(6), 2189-2198. https://doi.org/10.1021/acs.biomac.6b00429
Journal Article Type | Article |
---|---|
Acceptance Date | May 16, 2016 |
Online Publication Date | May 16, 2016 |
Publication Date | Jun 13, 2016 |
Deposit Date | Jul 7, 2016 |
Publicly Available Date | Jul 7, 2016 |
Journal | Biomacromolecules |
Print ISSN | 1525-7797 |
Electronic ISSN | 1525-7797 |
Publisher | American Chemical Society |
Peer Reviewed | Peer Reviewed |
Volume | 17 |
Issue | 6 |
Pages | 2189-2198 |
DOI | https://doi.org/10.1021/acs.biomac.6b00429 |
Public URL | https://nottingham-repository.worktribe.com/output/795360 |
Publisher URL | http://pubs.acs.org/doi/abs/10.1021/acs.biomac.6b00429 |
Additional Information | This document is the Accepted Manuscript version of a Published Work that appeared in final form in Biomacromolecules, copyright ©2016 American Chemical Society after peer review and technical editing by the publisher. |
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Copyright Statement
Copyright information regarding this work can be found at the following address: http://creativecommons.org/licenses/by-nc/4.0
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