Vascular ageing and endothelial cell senescence: Molecular mechanisms of physiology and diseases

Regina, Carla; Panatta, Emanuele; Candi, Eleonora; Melino, Gerry; Amelio, Ivano; Balistreri, Carmela Rita; Annicchiarico-Petruzzelli, Margherita; Di Daniele, Nicola; Ruvolo, Giovanni

Abstract

Ageing leads to a progressive deterioration of structure and function of all organs over the time. During this process endothelial cells undergo senescence and manifest significant changes in their properties, resulting in impairment of the vascular functionality and neo-angiogenic capability. This ageing-dependent impairment of endothelial functions is considered a key factor contributing to vascular dysfunctions, which is responsible of several age-related diseases of the vascular system and other organs. Several mechanisms have been described to control ageing-related endothelial cell senescence including microRNAs, mitochondrial dysfunction and micro environmental stressors, such as hypoxia. In this review, we attempt to summarize the recent literature in the field, discussing the major mechanisms involved in endothelial cell senescence. We also underline key molecular aspects of ageing-associated vascular dysfunction in the attempt to highlight potential innovative therapeutic targets to delay the onset of age-related diseases.

Citation

Regina, C., Panatta, E., Candi, E., Melino, G., Amelio, I., Balistreri, C. R., …Ruvolo, G. (2016). Vascular ageing and endothelial cell senescence: Molecular mechanisms of physiology and diseases. Mechanisms of Ageing and Development, 159, 14-21. https://doi.org/10.1016/j.mad.2016.05.003

• Journal Article Type: Article
• Acceptance Date: May 3, 2016
• Online Publication Date: May 4, 2016
• Publication Date: 2016-10
• Deposit Date: Mar 31, 2020
• Journal: Mechanisms of Ageing and Development
• Print ISSN: 0047-6374
• Electronic ISSN: 1872-6216
• Publisher: Elsevier
• Peer Reviewed: Peer Reviewed
• Volume: 159
• Pages: 14-21
• DOI: https://doi.org/10.1016/j.mad.2016.05.003
• Public URL: https://nottingham-repository.worktribe.com/output/4235833
• Publisher URL: https://www.sciencedirect.com/science/article/abs/pii/S0047637416300598
• Additional Information: This article is maintained by: Elsevier; Article Title: Vascular ageing and endothelial cell senescence: Molecular mechanisms of physiology and diseases; Journal Title: Mechanisms of Ageing and Development; CrossRef DOI link to publisher maintained version: https://doi.org/10.1016/j.mad.2016.05.003; Content Type: article; Copyright: © 2016 Published by Elsevier Ireland Ltd.