Am�lie Savers
Infection-mediated priming of phagocytes protects against lethal secondary Aspergillus fumigatus challenge
Savers, Am�lie; Rasid, Orhan; Parlato, Marianna; Brock, Matthias; Jouvion, Gregory; Ryffel, Bernhard; Cavaillon, Jean-Marc; Eberl, Gerard; Ibrahim-Granet, Ouma�ma
Authors
Orhan Rasid
Marianna Parlato
MATTHIAS BROCK Matthias.Brock@nottingham.ac.uk
Associate Professor
Gregory Jouvion
Bernhard Ryffel
Jean-Marc Cavaillon
Gerard Eberl
Ouma�ma Ibrahim-Granet
Abstract
Phagocytes restrict the germination of Aspergillus fumigatus conidia and prevent the establishment of invasive pulmonary aspergillosis in immunecompetent mice. Here we report that immunecompetent mice recovering from a primary A. fumigatus challenge are protected against a secondary lethal challenge. Using RAGγc knock-out mice we show that this protection is independent of T, B and NK cells. In protected mice, lung phagocytes are recruited more rapidly and are more efficient in conidial phagocytosis and killing. Protection was also associated with an enhanced expression of CXCR2 and Dectin-1 on bone marrow phagocytes. We also show that protective lung cytokine and chemokine responses are induced more rapidly and with enhanced dynamics in protected mice. Our findings support the hypothesis that following a first encounter with a non-lethal dose of A. fumigatus conidia, the innate immune system is primed and can mediate protection against a secondary lethal infection.
Citation
Savers, A., Rasid, O., Parlato, M., Brock, M., Jouvion, G., Ryffel, B., …Ibrahim-Granet, O. (2016). Infection-mediated priming of phagocytes protects against lethal secondary Aspergillus fumigatus challenge. PLoS ONE, 11(4), Article e0153829. https://doi.org/10.1371/journal.pone.0153829
Journal Article Type | Article |
---|---|
Acceptance Date | Apr 4, 2016 |
Publication Date | Apr 14, 2016 |
Deposit Date | Mar 14, 2017 |
Publicly Available Date | Mar 14, 2017 |
Journal | PLoS ONE |
Electronic ISSN | 1932-6203 |
Publisher | Public Library of Science |
Peer Reviewed | Peer Reviewed |
Volume | 11 |
Issue | 4 |
Article Number | e0153829 |
DOI | https://doi.org/10.1371/journal.pone.0153829 |
Public URL | https://nottingham-repository.worktribe.com/output/785257 |
Publisher URL | http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0153829 |
Contract Date | Mar 14, 2017 |
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Copyright Statement
Copyright information regarding this work can be found at the following address: http://creativecommons.org/licenses/by/4.0
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