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Infection-mediated priming of phagocytes protects against lethal secondary Aspergillus fumigatus challenge

Savers, Am�lie; Rasid, Orhan; Parlato, Marianna; Brock, Matthias; Jouvion, Gregory; Ryffel, Bernhard; Cavaillon, Jean-Marc; Eberl, Gerard; Ibrahim-Granet, Ouma�ma

Infection-mediated priming of phagocytes protects against lethal secondary Aspergillus fumigatus challenge Thumbnail


Authors

Am�lie Savers

Orhan Rasid

Marianna Parlato

Gregory Jouvion

Bernhard Ryffel

Jean-Marc Cavaillon

Gerard Eberl

Ouma�ma Ibrahim-Granet



Abstract

Phagocytes restrict the germination of Aspergillus fumigatus conidia and prevent the establishment of invasive pulmonary aspergillosis in immunecompetent mice. Here we report that immunecompetent mice recovering from a primary A. fumigatus challenge are protected against a secondary lethal challenge. Using RAG?c knock-out mice we show that this protection is independent of T, B and NK cells. In protected mice, lung phagocytes are recruited more rapidly and are more efficient in conidial phagocytosis and killing. Protection was also associated with an enhanced expression of CXCR2 and Dectin-1 on bone marrow phagocytes. We also show that protective lung cytokine and chemokine responses are induced more rapidly and with enhanced dynamics in protected mice. Our findings support the hypothesis that following a first encounter with a non-lethal dose of A. fumigatus conidia, the innate immune system is primed and can mediate protection against a secondary lethal infection.

Journal Article Type Article
Acceptance Date Apr 4, 2016
Publication Date Apr 14, 2016
Deposit Date Mar 14, 2017
Publicly Available Date Mar 14, 2017
Journal PLoS ONE
Electronic ISSN 1932-6203
Publisher Public Library of Science
Peer Reviewed Peer Reviewed
Volume 11
Issue 4
Article Number e0153829
DOI https://doi.org/10.1371/journal.pone.0153829
Public URL https://nottingham-repository.worktribe.com/output/785257
Publisher URL http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0153829

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