The effect of maternal undernutrition before muscle differentiation on the muscle fiber development of the newborn lamb

Fahey, A. J.; Brameld, J. M.; Parr, T.; Buttery, P. J.

doi:10.2527/2005.83112564x

The juvenile hormone analogue, pyriproxifen, alters protein and fat composition of Tenebrio molitor larvae (2024)
Journal Article
Hill, V., Lopez-Viso, C., Brameld, J., Salter, A., & Parr, T. (2024). The juvenile hormone analogue, pyriproxifen, alters protein and fat composition of Tenebrio molitor larvae. Journal of Insects as Food and Feed, https://doi.org/10.1163/23524588-00001043

Maximising the yield of product from livestock is common practice in the agriculture industry and there is potential to extend this practice to the emerging insect industry, to produce high-quality, sustainable protein. Tenebrio molitor larvae, commo... Read More about The juvenile hormone analogue, pyriproxifen, alters protein and fat composition of Tenebrio molitor larvae.

Active vitamin D increases myogenic differentiation in C2C12 cells via a vitamin D response element on the myogenin promoter (2024)
Journal Article
Alliband, K. H., Parr, T., Jethwa, P. H., & Brameld, J. M. (2024). Active vitamin D increases myogenic differentiation in C2C12 cells via a vitamin D response element on the myogenin promoter. Frontiers in Physiology, 14, Article 1322677. https://doi.org/10.3389/fphys.2023.1322677

Background: Skeletal muscle development during embryogenesis depends on proliferation of myoblasts followed by differentiation into myotubes/multinucleated myofibers. Vitamin D (VD) has been shown to affect these processes, but there is conflicting e... Read More about Active vitamin D increases myogenic differentiation in C2C12 cells via a vitamin D response element on the myogenin promoter.

Changes in nutrient composition and gene expression in growing mealworms (Tenebrio molitor) (2023)
Journal Article
Lopez-Viso, C., Castellanos-Uribe, M., May, T., Brameld, J., Salter, A., & Parr, T. (2023). Changes in nutrient composition and gene expression in growing mealworms (Tenebrio molitor). Journal of Insects as Food and Feed, https://doi.org/10.1163/23524588-20230143

Insects are of high interest as a sustainable source of nutrients to be included in the food production system. The larvae of Tenebrio molitor, commonly known as yellow mealworms (MW), have a high protein content, which means potential applications i... Read More about Changes in nutrient composition and gene expression in growing mealworms (Tenebrio molitor).

Fermentation technology enhances the nutritional quality of underutilized Bambara groundnut – a review (2023)
Journal Article
Tee, A. J., Lim, Y. S., Brameld, J. M., Massawe, F., Parr, T., & Salter, A. M. (2023). Fermentation technology enhances the nutritional quality of underutilized Bambara groundnut – a review. Food Biotechnology, 37(2), 106-135. https://doi.org/10.1080/08905436.2023.2201307

Bambara groundnut (BG) offers great potential for sustainable food and nutritional security in the face of a growing population and changing climate. However, its utilization remains restricted by the hard-to-cook phenomenon of seed and the presence... Read More about Fermentation technology enhances the nutritional quality of underutilized Bambara groundnut – a review.

The effects of exogenous fibrolytic enzymes on the in vitro release of xylooligosaccharides and monosaccharides varies across six varieties of wheat (2022)
Journal Article
Dale, T., Bedford, M. R., King, J., Tucker, G. A., Brameld, J. M., & Parr, T. (2023). The effects of exogenous fibrolytic enzymes on the in vitro release of xylooligosaccharides and monosaccharides varies across six varieties of wheat. Animal Feed Science and Technology, 295, Article 115526. https://doi.org/10.1016/j.anifeedsci.2022.115526

Wheat is a widely used cereal grain for pig and poultry feeds globally. Despite this, there are noticeable differences in its nutritive value, potentially due to varying characteristics like inherent non-starch polysaccharide (NSP) content and compos... Read More about The effects of exogenous fibrolytic enzymes on the in vitro release of xylooligosaccharides and monosaccharides varies across six varieties of wheat.

The effects of exogenous fibrolytic enzymes on the in vitro generation of xylooligosaccharides and monosaccharides is dependent upon cereal type (2022)
Journal Article
Dale, T., Bedford, M. R., Tucker, G. A., Brameld, J. M., & Parr, T. (2022). The effects of exogenous fibrolytic enzymes on the in vitro generation of xylooligosaccharides and monosaccharides is dependent upon cereal type. Animal Feed Science and Technology, 292, Article 115406. https://doi.org/10.1016/j.anifeedsci.2022.115406

Fibrolytic enzymes are routinely added to non-ruminant livestock feeds to help degrade the non-starch polysaccharide (NSP) contents and thereby improve feed efficiency. This study investigated the range of xylooligosaccharides (XOS) and monosaccharid... Read More about The effects of exogenous fibrolytic enzymes on the in vitro generation of xylooligosaccharides and monosaccharides is dependent upon cereal type.

In vitro Effects of Biologically Active Vitamin D on Myogenesis: A Systematic Review (2021)
Journal Article
Alliband, K. H., Kozhevnikova, S. V., Parr, T., Jethwa, P. H., & Brameld, J. M. (2021). In vitro Effects of Biologically Active Vitamin D on Myogenesis: A Systematic Review. Frontiers in Physiology, 12, Article 736708. https://doi.org/10.3389/fphys.2021.736708

Vitamin D (VD) deficiency is associated with muscle weakness. A reduction in the incidence of falls in the elderly following VD supplementation and identification of the VD receptor within muscle cells suggests a direct effect of VD on muscle, but li... Read More about In vitro Effects of Biologically Active Vitamin D on Myogenesis: A Systematic Review.

Suitability of insects for animal feeding. (2021)
Book Chapter
Hawkey, K., Brameld, J., Parr, T., Salter, A., & Hall, H. (2021). Suitability of insects for animal feeding. In H. Hall, E. Fitches, & R. Smith (Eds.), Insects as Animal Feed: Novel Ingredients for Use in Pet, Aquaculture and Livestock Diets (26-38). CAB International. https://doi.org/10.1079/9781789245929.0004

This chapter explores the nutritional composition of insects and the potential benefits and drawbacks for their inclusion into pet, poultry, pig, ruminant and aquatic animal feeds. Six species are most commonly described for use in animal feed, namel... Read More about Suitability of insects for animal feeding..

Insects: A Potential Source of Protein and Other Nutrients for Feed and Food (2020)
Journal Article
Hawkey, K. J., Lopez-Viso, C., Brameld, J. M., Parr, T., & Salter, A. M. (2021). Insects: A Potential Source of Protein and Other Nutrients for Feed and Food. Annual Review of Animal Biosciences, 9(1), 333-354. https://doi.org/10.1146/annurev-animal-021419-083930

© 2021 Annual Reviews Inc.. All rights reserved. Sustainable production of healthy food for a growing global population, in the face of the uncertainties of climate change, represents a major challenge for the coming decade. Livestock provide food wi... Read More about Insects: A Potential Source of Protein and Other Nutrients for Feed and Food.

The effects of exogenous xylanase supplementation on the in vivo generation of xylooligosaccharides and monosaccharides in broilers fed a wheat-based diet (2020)
Journal Article
Dale, T., Hannay, I., Bedford, M. R., Tucker, G. A., Brameld, J., & Parr, T. (2020). The effects of exogenous xylanase supplementation on the in vivo generation of xylooligosaccharides and monosaccharides in broilers fed a wheat-based diet. British Poultry Science, 61(4), 471-481. https://doi.org/10.1080/00071668.2020.1751805

1. This study aimed to quantify xylanase-induced changes in soluble monosaccharides, xylooligosaccharides (XOS) and volatile fatty acid (VFA) contents of the different sections of the GIT and whether these relate to altered bird performance. 2. An... Read More about The effects of exogenous xylanase supplementation on the in vivo generation of xylooligosaccharides and monosaccharides in broilers fed a wheat-based diet.

Author Correction: The Beta-adrenergic agonist, Ractopamine, increases skeletal muscle expression of Asparagine Synthetase as part of an integrated stress response gene program (2019)
Journal Article
Brown, D., Ryan, K., Daniel, Z., Mareko, M., Talbot, R., Moreton, J., …Brameld, J. M. (2019). Author Correction: The Beta-adrenergic agonist, Ractopamine, increases skeletal muscle expression of Asparagine Synthetase as part of an integrated stress response gene program. Scientific Reports, 9(1), Article 15412. https://doi.org/10.1038/s41598-019-43807-1

© 2019, The Author(s). In the Supplementary Information file originally published with this Article, Table 2 was omitted. This error has been corrected in the Supplementary Information that now accompanies the Article.

Effect of adeno-associated virus (AAV)-mediated overexpression of PEPCK-M (Pck2) on Clenbuterol-induced muscle growth (2019)
Journal Article
Loczenski-Brown, D. M., Jones, S., Luckett, J., Daniel, Z., Brearley, M. C., Ebling, F. J. P., …Brameld, J. M. (2019). Effect of adeno-associated virus (AAV)-mediated overexpression of PEPCK-M (Pck2) on Clenbuterol-induced muscle growth. PLoS ONE, 14(6), 1-12. https://doi.org/10.1371/journal.pone.0218970

We previously identified PEPCK-M (encoded by the Pck2 gene) to be highly up-regulated in skeletal muscle of pigs treated with Ractopamine, an anabolic beta-adrenergic receptor agonist. To determine whether PEPCK-M had a causative role in modulating t... Read More about Effect of adeno-associated virus (AAV)-mediated overexpression of PEPCK-M (Pck2) on Clenbuterol-induced muscle growth.

The active form of vitamin D, Calcitriol, induces vasodilation in the rat aorta (2015)
Journal Article
Al-Harbi, L., Brameld, J. M., & Parr, T. (2015). The active form of vitamin D, Calcitriol, induces vasodilation in the rat aorta. Proceedings of the Nutrition Society, 74(OCE5), https://doi.org/10.1017/S0029665115003407

Myosin heavy chain mRNA isoforms are expressed in two distinct cohorts during C2C12 myogenesis (2011)
Journal Article
Brown, D. M., Parr, T., & Brameld, J. M. (2012). Myosin heavy chain mRNA isoforms are expressed in two distinct cohorts during C2C12 myogenesis. Journal of Muscle Research and Cell Motility, 32(6), 383-390. https://doi.org/10.1007/s10974-011-9267-4

The regulation of muscle fibre transitions has mainly been studied in vivo using conventional histological or immunohistochemical techniques. In order to investigate the molecular regulation of myosin heavy chain (MyHC) isoform expression in cell cul... Read More about Myosin heavy chain mRNA isoforms are expressed in two distinct cohorts during C2C12 myogenesis.

Use of the Affymetrix human GeneChip array and genomic DNA hybridisation probe selection to study ovine transcriptomes (2011)
Journal Article
Graham, N. S., May, S. T., Daniel, Z. C., Emmerson, Z. F., Brameld, J. M., & Parr, T. (2011). Use of the Affymetrix human GeneChip array and genomic DNA hybridisation probe selection to study ovine transcriptomes. animal, 5(6), 861-866. https://doi.org/10.1017/S1751731110002533

Affymetrix GeneChip microarrays are a powerful tool to study global gene expression profiles and have been used on many species. However, no sheep-specific Affymetrix GeneChip is currently available and the bovine array is fairly limited in its cover... Read More about Use of the Affymetrix human GeneChip array and genomic DNA hybridisation probe selection to study ovine transcriptomes.

Calpastatin is associated with lymphovascular invasion in breast cancer (2011)
Journal Article
Storr, S. J., Mohammed, R. A., Woolston, C. M., Green, A. R., Parr, T., Spiteri, I., …Martin, S. G. (2011). Calpastatin is associated with lymphovascular invasion in breast cancer. Breast, 20(5), 413-418. https://doi.org/10.1016/j.breast.2011.04.002

Metastasis of breast cancer is a major contributor to mortality. Histological assessment of vascular invasion (VI) provides important prognostic information and demonstrates that VI occurs predominantly via lymphatics in breast cancer. We sought to e... Read More about Calpastatin is associated with lymphovascular invasion in breast cancer.

The calpain system and cancer (2011)
Journal Article
Storr, S. J., Carragher, N. O., Frame, M. C., Parr, T., & Martin, S. G. (2011). The calpain system and cancer. Nature Reviews Cancer, 11(5), 364-374. https://doi.org/10.1038/nrc3050

The calpains are a conserved family of cysteine proteinases that catalyse the controlled proteolysis of many specific substrates. Calpain activity is implicated in several fundamental physiological processes, including cytoskeletal remodelling, cellu... Read More about The calpain system and cancer.

Regulation of ovine and porcine stearoyl coenzyme A desaturase gene promoters by fatty acids and sterols (2010)
Journal Article
Zulkifli, R. M., Parr, T., Salter, A. M., & Brameld, J. M. (2010). Regulation of ovine and porcine stearoyl coenzyme A desaturase gene promoters by fatty acids and sterols. Journal of Animal Science, 88(8), 2565-2575. https://doi.org/10.2527/jas.2009-2603

Stearoyl CoA desaturase (SCD) is responsible for converting SFA into MUFA and plays an important role in regulating the fatty acid composition of tissues. Although the number of SCD isoforms differs among species, SCD-1 is the predominant isoform exp... Read More about Regulation of ovine and porcine stearoyl coenzyme A desaturase gene promoters by fatty acids and sterols.

Examination of myosin heavy chain isoform expression in ovine skeletal muscles (2009)
Journal Article
Hemmings, K. M., Parr, T., Daniel, Z. C., Picard, B., Buttery, P. J., & Brameld, J. M. (2009). Examination of myosin heavy chain isoform expression in ovine skeletal muscles. Journal of Animal Science, 87(12), 3915-3922. https://doi.org/10.2527/jas.2009-2067

The contractile and associated metabolic characteristics of muscles are determined by their myosin heavy chain (MHC) isoform expression. In large mammals, the level of MHCIIB expression, which is associated with fast glycolytic-type muscle fibers, ha... Read More about Examination of myosin heavy chain isoform expression in ovine skeletal muscles.

The effect of maternal undernutrition before muscle differentiation on the muscle fiber development of the newborn lamb (2005)
Journal Article
Fahey, A. J., Brameld, J. M., Parr, T., & Buttery, P. J. (2005). The effect of maternal undernutrition before muscle differentiation on the muscle fiber development of the newborn lamb. Journal of Animal Science, 83(11), 2564-2571. https://doi.org/10.2527/2005.83112564x

There is a need to improve the lean tissue content of ruminant animals destined for meat production. Muscle fiber number is set during fetal development. The effect of undernutrition of pregnant ewes on subsequent muscle fiber characteristics of thei... Read More about The effect of maternal undernutrition before muscle differentiation on the muscle fiber development of the newborn lamb.

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