The calpain system and cancer

Storr, Sarah J.; Carragher, Neil O.; Frame, Margaret C.; Parr, Tim; Martin, Stewart G.

Abstract

The calpains are a conserved family of cysteine proteinases that catalyse the controlled proteolysis of many specific substrates. Calpain activity is implicated in several fundamental physiological processes, including cytoskeletal remodelling, cellular signalling, apoptosis and cell survival. Calpain expression is altered during tumorigenesis, and the proteolysis of numerous substrates, such as inhibitors of nuclear factor-Î °B (IκB), focal adhesion proteins (including, focal adhesion kinase and talin) and proto-oncogenes (for example, MYC), has been implicated in tumour pathogenesis. Recent evidence indicates that the increased expression of certain family members might influence the response to cancer therapies, providing justification for the development of novel calpain inhibitors. © 2011 Macmillan Publishers Limited. All rights reserved.

Citation

Storr, S. J., Carragher, N. O., Frame, M. C., Parr, T., & Martin, S. G. (2011). The calpain system and cancer. Nature Reviews Cancer, 11(5), 364-374. https://doi.org/10.1038/nrc3050

• Journal Article Type: Review
• Online Publication Date: Apr 21, 2011
• Publication Date: May 1, 2011
• Deposit Date: Oct 12, 2020
• Journal: Nature Reviews Cancer
• Print ISSN: 1474-175X
• Electronic ISSN: 1474-1768
• Publisher: Nature Publishing Group
• Peer Reviewed: Peer Reviewed
• Volume: 11
• Issue: 5
• Pages: 364-374
• DOI: https://doi.org/10.1038/nrc3050
• Public URL: https://nottingham-repository.worktribe.com/output/3153758
• Publisher URL: https://www.nature.com/articles/nrc3050