All Outputs (19)

The METTL3 RNA Methyltransferase Regulates Transcriptional Networks in Prostate Cancer (2022)
Journal Article

Prostate cancer (PCa) is a leading cause of cancer-related deaths and is driven by aberrant androgen receptor (AR) signalling. For this reason, androgen deprivation therapies (ADTs) that suppress androgen-induced PCa progression either by preventing... Read More about The METTL3 RNA Methyltransferase Regulates Transcriptional Networks in Prostate Cancer.

Antimicrobial resistance in dairy slurry tanks: a critical point for measurement and control (2022)
Journal Article

Waste from dairy production is one of the largest sources of contamination from antimicrobial resistant bacteria (ARB) and genes (ARGs) in many parts of the world. However, studies to date do not provide necessary evidence to inform antimicrobial res... Read More about Antimicrobial resistance in dairy slurry tanks: a critical point for measurement and control.

Root architecture and leaf photosynthesis traits and associations with nitrogen-use efficiency in landrace-derived lines in wheat (2022)
Journal Article

Root system architecture (RSA) is important in optimizing the use of nitrogen. High-throughput phenotyping techniques may be used to study root system architecture traits under controlled environments. A root phenotyping platform, consisting of germi... Read More about Root architecture and leaf photosynthesis traits and associations with nitrogen-use efficiency in landrace-derived lines in wheat.

Transcriptional networks underpinning ploidy related increased leaf potassium in neo-tetraploids (2022)
Journal Article

Whole-genome duplication generates a tetraploid from a diploid. Newly created tetraploids (neo-tetraploids) of Arabidopsis (Arabidopsis thaliana) have elevated leaf potassium (K), compared to their diploid progenitor. Micro-grafting has previously es... Read More about Transcriptional networks underpinning ploidy related increased leaf potassium in neo-tetraploids.

Transcriptional network underpinning ploidy-related elevated leaf potassium in neo-tetraploids (2022)
Journal Article

Whole-genome duplication generates a tetraploid from a diploid. Newly created tetraploids (neo-tetraploids) of Arabidopsis (Arabidopsis thaliana) have elevated leaf potassium (K), compared to their diploid progenitor. Micro-grafting has previously es... Read More about Transcriptional network underpinning ploidy-related elevated leaf potassium in neo-tetraploids.

Root angle is controlled by EGT1in cereal crops employing anantigravitropic mechanism (2022)
Journal Article

Root angle in crops represents a key trait for efficient capture of soil resources. Root angle is determined by competing gravitropic versus anti-gravitropic offset (AGO) mechanisms. Here we report a new root angle regulatory gene termed ENHANCED GRA... Read More about Root angle is controlled by EGT1in cereal crops employing anantigravitropic mechanism.

Ethylene inhibits rice root elongation in compacted soil via ABA- and auxin-mediated mechanisms (2022)
Journal Article

Soil compaction represents a major agronomic challenge, inhibiting root elongation and impacting crop yields. Roots use ethylene to sense soil compaction as the restricted air space causes this gaseous signal to accumulate around root tips. Ethylene... Read More about Ethylene inhibits rice root elongation in compacted soil via ABA- and auxin-mediated mechanisms.

An oxygen-sensing mechanism for angiosperm adaptation to altitude (2022)
Journal Article

Flowering plants (angiosperms) can grow at extreme altitudes, and have been observed growing as high as 6,400 metres above sea level1,2; however, the molecular mechanisms that enable plant adaptation specifically to altitude are unknown. One distingu... Read More about An oxygen-sensing mechanism for angiosperm adaptation to altitude.

A two-step adaptive walk rewires nutrient transport in a challenging edaphic environment (2022)
Journal Article

Most well-characterized cases of adaptation involve single genetic loci. Theory suggests that multilocus adaptive walks should be common, but these are challenging to identify in natural populations. Here, we combine trait mapping with population gen... Read More about A two-step adaptive walk rewires nutrient transport in a challenging edaphic environment.

Root system size and root hair length are key phenes for nitrate acquisition and biomass production across natural variation in Arabidopsis (2022)
Journal Article

The role of root phenes in nitrogen (N) acquisition and biomass production was evaluated in 10 contrasting natural accessions of Arabidopsis thaliana L. Seedlings were grown on vertical agar plates with two different nitrate supplies. The low N treat... Read More about Root system size and root hair length are key phenes for nitrate acquisition and biomass production across natural variation in Arabidopsis.

More sustainable vegetable oil: Balancing productivity with carbon storage opportunities (2022)
Journal Article

Intensive cultivation and post-harvest vegetable oil production stages are major sources of greenhouse gas (GHG) emissions. Variation between production systems and reporting disparity have resulted in discordance in previous emissions estimates. The... Read More about More sustainable vegetable oil: Balancing productivity with carbon storage opportunities.

Identification of QTL and underlying genes for root system architecture associated with nitrate nutrition in hexaploid wheat (2022)
Journal Article

The root system architecture (RSA) of a crop has a profound effect on the uptake of nutrients and consequently the potential yield. However, little is known about the genetic basis of RSA and resource adaptive responses in wheat (Triticum aestivum L.... Read More about Identification of QTL and underlying genes for root system architecture associated with nitrate nutrition in hexaploid wheat.

First Trimester Maternal Homocysteine and Embryonic and Fetal Growth: The Rotterdam Periconception Cohort (2022)
Journal Article

Homocysteine is a marker for derangements in one-carbon metabolism. Elevated homocysteine may represent a causal link between poor maternal nutrition and impaired embryonic and fetal development. We sought to investigate associations between referenc... Read More about First Trimester Maternal Homocysteine and Embryonic and Fetal Growth: The Rotterdam Periconception Cohort.

X-ray CT reveals 4D root system development and lateral root responses to nitrate in soil (2022)
Journal Article

The spatial arrangement of the root system, termed root system architecture, is important for resource acquisition as it directly affects the soil zone explored. Methods for phenotyping roots are mostly destructive, which prevents analysis of roots o... Read More about X-ray CT reveals 4D root system development and lateral root responses to nitrate in soil.

Illuminating Host-Parasite Interaction at the Cellular and Subcellular Levels with Infrared Microspectroscopy (2022)
Journal Article

Toxoplasma gondii (T. gondii) is an opportunistic protozoan that can cause brain infection and other serious health consequences in immuno-compromised individuals. This parasite has a remarkable ability to cross biological barriers and exploit the ho... Read More about Illuminating Host-Parasite Interaction at the Cellular and Subcellular Levels with Infrared Microspectroscopy.

Mitochondrial retrograde signaling through UCP1-mediated inhibition of the plant oxygen-sensing pathway (2022)
Journal Article

Mitochondrial retrograde signaling is an important component of intracellular stress signaling in eukaryotes. UNCOUPLING PROTEIN (UCP)1 is an abundant plant inner-mitochondrial membrane protein with multiple functions including uncoupled respiration... Read More about Mitochondrial retrograde signaling through UCP1-mediated inhibition of the plant oxygen-sensing pathway.

Root traits for low input agroecosystems in Africa: Lessons from three case studies (2022)
Journal Article

In many regions across Africa, agriculture is largely based on low-input and small-holder farming systems that use little inorganic fertilisers and have limited access to irrigation and mechanisation. Improving agricultural practices and developing n... Read More about Root traits for low input agroecosystems in Africa: Lessons from three case studies.

A Yeast-Based Functional Assay to Study Plant N-Degron – N-Recognin Interactions (2022)
Journal Article

The N-degron pathway is a branch of the ubiquitin-proteasome system where amino-terminal residues serve as degradation signals. In a synthetic biology approach, we expressed ubiquitin ligase PRT6 and ubiquitin conjugating enzyme 2 (AtUBC2) from Arabi... Read More about A Yeast-Based Functional Assay to Study Plant N-Degron – N-Recognin Interactions.

Hippocampal Disinhibition Reduces Contextual and Elemental Fear Conditioning While Sparing the Acquisition of Latent Inhibition (2022)
Journal Article

Hippocampal neural disinhibition, i.e., reduced GABAergic inhibition, is a key feature of schizophrenia pathophysiology. The hippocampus is an important part of the neural circuitry that controls fear conditioning and can also modulate prefrontal and... Read More about Hippocampal Disinhibition Reduces Contextual and Elemental Fear Conditioning While Sparing the Acquisition of Latent Inhibition.