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Photosensitiser-gold nanoparticle conjugates for photodynamic therapy of cancer (2018)
Journal Article
García Calavia, P., Bruce, G., Pérez-García, L., & Russell, D. A. (2018). Photosensitiser-gold nanoparticle conjugates for photodynamic therapy of cancer. Photochemical & Photobiological Sciences Photochemical and Photobiological Sciences, 17(11), 1534-1552. https://doi.org/10.1039/c8pp00271a

Gold nanoparticles (AuNPs) have been extensively studied within biomedicine due to their biocompatibility and low toxicity. In particular, AuNPs have been widely used to deliver photosensitiser agents for photodynamic therapy (PDT) of cancer. Here we... Read More about Photosensitiser-gold nanoparticle conjugates for photodynamic therapy of cancer.

Anthropogenic environmental drivers of antimicrobial resistance in wildlife (2018)
Journal Article
Swift, B. M., Bennett, M., Waller, K., Dodd, C., Murray, A., Gomes, R. L., …Arnold, K. E. (2019). Anthropogenic environmental drivers of antimicrobial resistance in wildlife. Science of the Total Environment, 649, 12-20. https://doi.org/10.1016/j.scitotenv.2018.08.180

The isolation of antimicrobial resistant bacteria (ARB) from wildlife living adjacent to humans has led to the suggestion that such antimicrobial resistance (AMR) is anthropogenically driven by exposure to antimicrobials and ARB. However, ARB have al... Read More about Anthropogenic environmental drivers of antimicrobial resistance in wildlife.

Visualising ligand-binding to a GPCR in vivo using nanoBRET (2018)
Journal Article
Carvalheira Alcobia, D., Ziegler, A. I., Kondrashov, A., Comeo, E., Mistry, S., Kellam, B., …Sloan, E. K. (2018). Visualising ligand-binding to a GPCR in vivo using nanoBRET. iScience, 6(8), 280-288. https://doi.org/10.1016/j.isci.2018.08.006

© 2018 The Author(s) The therapeutic action of a drug depends on its ability to engage with its molecular target in vivo. However, current drug discovery strategies quantify drug levels within organs rather than determining the binding of drugs direc... Read More about Visualising ligand-binding to a GPCR in vivo using nanoBRET.

Extrusion 3D printing of paracetamol tablets from a single formulation with tunable release profiles through control of tablet geometry (2018)
Journal Article
Khaled, S. A., Alexander, M. R., Irvine, D. J., Wildman, R. D., Wallace, M. J., Sharpe, S., …Roberts, C. J. (2018). Extrusion 3D printing of paracetamol tablets from a single formulation with tunable release profiles through control of tablet geometry. AAPS PharmSciTech, 19(8), 3403–3413. https://doi.org/10.1208/s12249-018-1107-z

An extrusion based 3D printer was used to fabricate paracetamol tablets with different geometries (mesh, ring, and solid) from a single paste-based formulation formed from standard pharmaceutical ingredients. The tablets demonstrate that tunable drug... Read More about Extrusion 3D printing of paracetamol tablets from a single formulation with tunable release profiles through control of tablet geometry.

Public health strategies to reduce sugar intake in the UK: An exploration of public perceptions using digital spaces (2018)
Journal Article
Swift, J. A., Strathearn, L., Morris, A., Chi, Y., Townsend, T., & Pearce, J. (2018). Public health strategies to reduce sugar intake in the UK: An exploration of public perceptions using digital spaces. Nutrition Bulletin, 43(3), 238-247. https://doi.org/10.1111/nbu.12346

Background: To explore UK public perceptions of children’s sugar consumption, Public Health England’s Change4Life Sugar Smart App and the Soft Drinks Industry Levy, using solicited and unsolicited digital data. Methods: Data from three digital space... Read More about Public health strategies to reduce sugar intake in the UK: An exploration of public perceptions using digital spaces.

Cytotoxic potential of ethanol extract of Parquetina nigrescens on MCF-7, C4-2WT, HT 29 and HTC 116 cell lines (2018)
Journal Article
M. Onyegeme-Okerenta, B., Agyare, C., D. Bradshaw, T., & A. Spriggs, K. (2018). Cytotoxic potential of ethanol extract of Parquetina nigrescens on MCF-7, C4-2WT, HT 29 and HTC 116 cell lines. African journal of pharmacy and pharmacology, 12(23), 310-318. https://doi.org/10.5897/ajpp2018.4947

The cytotoxic activity of ethanol extract of Parquetina nigrescen was investigated using a (3-(4, 5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay, methylene blue and Trypan Blue exclusion assay on four human cancer cell lines, MCF... Read More about Cytotoxic potential of ethanol extract of Parquetina nigrescens on MCF-7, C4-2WT, HT 29 and HTC 116 cell lines.

Evaluation of extraction and normalisation strategies for the analysis of lipids in placental vessels (2018)
Journal Article
Sander, K. N., Hay, D. P., Broughton-Pipkin, F., Khan, R. N., & Barrett, D. A. (2018). Evaluation of extraction and normalisation strategies for the analysis of lipids in placental vessels. Journal of Pharmaceutical and Biomedical Analysis, 160, 297-300. https://doi.org/10.1016/j.jpba.2018.08.012

© 2018 The analysis of lipids in tough or fibrous biological tissues can be challenging due to difficulties in obtaining a representative sample following homogenisation of the tissue. Furthermore, the choice of normalisation method can have a major... Read More about Evaluation of extraction and normalisation strategies for the analysis of lipids in placental vessels.

n−3 polyunsaturated N-acylethanolamines are CB2 cannabinoid receptor-preferring endocannabinoids (2018)
Journal Article
Alharthi, N., Christensen, P., Hourani, W., Ortori, C., Barrett, D. A., Bennett, A. J., …Alexander, S. P. (2018). n−3 polyunsaturated N-acylethanolamines are CB2 cannabinoid receptor-preferring endocannabinoids. Biochimica et Biophysica Acta Molecular and Cell Biology of Lipids, 1863(11), 1433-1440. https://doi.org/10.1016/j.bbalip.2018.08.003

Anandamide, the first identified endogenous cannabinoid and TRPV1 agonist, is one of a series of endogenous N-acylethanolamines, NAEs. We have generated novel assays to quantify the levels of multiple NAEs in biological tissues and their rates of hyd... Read More about n−3 polyunsaturated N-acylethanolamines are CB2 cannabinoid receptor-preferring endocannabinoids.

A low FODMAP diet is associated with changes in the microbiota and reduction in breath hydrogen but not colonic volume in healthy subjects (2018)
Journal Article
Sloan, T. J., Jalanka, J., Major, G. A. D., Krishnasamy, S., Pritchard, S., Abdelrazig, S., …Spiller, R. C. (2018). A low FODMAP diet is associated with changes in the microbiota and reduction in breath hydrogen but not colonic volume in healthy subjects. PLoS ONE, 13(7), Article e0201410. https://doi.org/10.1371/journal.pone.0201410

Background & aims Ingestion of poorly digested, fermentable carbohydrates (fermentable oligo-, di-, mono-saccharides and polyols; FODMAPs) have been implicated in exacerbating intestinal symptoms and the reduction of intake with symptom alleviatio... Read More about A low FODMAP diet is associated with changes in the microbiota and reduction in breath hydrogen but not colonic volume in healthy subjects.

Surface-Mediated Supramolecular Self-Assembly of Protein, Peptide, and Nucleoside Derivatives: From Surface Design to the Underlying Mechanism and Tailored Functions (2018)
Journal Article
Yang, B., Adams, D. J., Marlow, M., & Zelzer, M. (2018). Surface-Mediated Supramolecular Self-Assembly of Protein, Peptide, and Nucleoside Derivatives: From Surface Design to the Underlying Mechanism and Tailored Functions. Langmuir, 34(50), 15109-15125. https://doi.org/10.1021/acs.langmuir.8b01165

Among the many parameters that have been explored to exercise control over self-assembly processes, the influence of surface properties on self-assembly has been recognized as important but has received considerably less attention than other factors.... Read More about Surface-Mediated Supramolecular Self-Assembly of Protein, Peptide, and Nucleoside Derivatives: From Surface Design to the Underlying Mechanism and Tailored Functions.

Survivor perspectives on the role of the community pharmacist in breast cancer services (2018)
Journal Article
Tutt, L., Thornley, T., Chen, L., & Anderson, C. (2018). Survivor perspectives on the role of the community pharmacist in breast cancer services. Research in Social and Administrative Pharmacy, 14(8), e31. https://doi.org/10.1016/j.sapharm.2018.05.042

Background: Breast cancer is the most common cancer in the UK. Due to advances in treatment and earlier diagnosis, people are surviving for longer and often require long-term medication. The increased demand for breast cancer-focused primary care ser... Read More about Survivor perspectives on the role of the community pharmacist in breast cancer services.

Lipophilic activated ester prodrug approach for drug delivery to the intestinal lymphatic system (2018)
Journal Article
Lee, J. B., Zgair, A., Malec, J., Kim, T. H., Kim, M. G., Ali, J., …Gershkovich, P. (2018). Lipophilic activated ester prodrug approach for drug delivery to the intestinal lymphatic system. Journal of Controlled Release, 286, 10-19. https://doi.org/10.1016/j.jconrel.2018.07.022

The intestinal lymphatic system plays an important role in the pathophysiology of multiple diseases including lymphomas, cancer metastasis, autoimmune diseases, and human immunodeficiency virus (HIV) infection. It is thus an important compartment for... Read More about Lipophilic activated ester prodrug approach for drug delivery to the intestinal lymphatic system.

Monovalent ions modulate the flux through multiple folding pathways of an RNA pseudoknot (2018)
Journal Article
Roca, J., Hori, N., Baral, S., Velmurugu, Y., Narayanan, R., Narayanan, P., …Ansari, A. (2018). Monovalent ions modulate the flux through multiple folding pathways of an RNA pseudoknot. Proceedings of the National Academy of Sciences, 115(31), E7313-E7322. https://doi.org/10.1073/pnas.1717582115

The functions of RNA pseudoknots (PKs), which are minimal tertiary structural motifs and an integral part of several ribozymes and ribonucleoprotein complexes, are determined by their structure, stability, and dynamics. Therefore, it is important to... Read More about Monovalent ions modulate the flux through multiple folding pathways of an RNA pseudoknot.

Sustainable Syntheses of (-)-Jerantinines A & e and Structural Characterisation of the Jerantinine-Tubulin Complex at the Colchicine Binding Site (2018)
Journal Article
Smedley, C. J., Stanley, P. A., Qazzaz, M. E., Prota, A. E., Olieric, N., Collins, H., …Moses, J. E. (2018). Sustainable Syntheses of (-)-Jerantinines A & e and Structural Characterisation of the Jerantinine-Tubulin Complex at the Colchicine Binding Site. Scientific Reports, 8(1), Article 10617. https://doi.org/10.1038/s41598-018-28880-2

The jerantinine family of Aspidosperma indole alkaloids from Tabernaemontana corymbosa are potent microtubule-targeting agents with broad spectrum anticancer activity. The natural supply of these precious metabolites has been significantly disrupted... Read More about Sustainable Syntheses of (-)-Jerantinines A & e and Structural Characterisation of the Jerantinine-Tubulin Complex at the Colchicine Binding Site.

Pseudomonas aeruginosa quorum sensing systems as drug discovery targets: current position and future perspectives (2018)
Journal Article
Soukarieh, F., Williams, P., Stocks, M. J., & Camara, M. (in press). Pseudomonas aeruginosa quorum sensing systems as drug discovery targets: current position and future perspectives. Journal of Medicinal Chemistry, https://doi.org/10.1021/acs.jmedchem.8b00540

Antimicrobial resistance (AMR) is a serious threat to public health globally, manifested by the frequent emergence of multi-drug resistant pathogens that render current chemotherapy inadequate. Health organizations worldwide have recognized the sever... Read More about Pseudomonas aeruginosa quorum sensing systems as drug discovery targets: current position and future perspectives.

Omega-6 oxylipins generated by soluble epoxide hydrolase are associated with knee osteoarthritis (2018)
Journal Article
Valdes, A. M., Ravipati, S., Pousinis, P., Menni, C., Mangino, M., Abhishek, A., …Doherty, M. (in press). Omega-6 oxylipins generated by soluble epoxide hydrolase are associated with knee osteoarthritis. Journal of Lipid Research, 59(7), Article jlr.P085118. https://doi.org/10.1194/jlr.P085118

Omega-6 fatty acids are important inflammatory mediators increased in joints with osteoarthritis (OA) joints. To investigate the relationship between omega-6 fatty acids and knee OA 22 omega-6 lipids (arachidonic acid, linoleic acid and 20 oxylipins)... Read More about Omega-6 oxylipins generated by soluble epoxide hydrolase are associated with knee osteoarthritis.

A complex interplay between the extracellular matrix and the innate immune response to microbial pathogens (2018)
Journal Article
Tomlin, H., & Piccinini, A. M. (2018). A complex interplay between the extracellular matrix and the innate immune response to microbial pathogens. Immunology, 155(2), 186-201. https://doi.org/10.1111/imm.12972

The role of the host extracellular matrix (ECM) in infection tends to be neglected. However, the complex interactions between invading pathogens, host tissues and immune cells occur in the context of the ECM. On the pathogen side, a variety of surfac... Read More about A complex interplay between the extracellular matrix and the innate immune response to microbial pathogens.