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All Outputs (19)

Evaluating a clinical tool (FAMCAT) for identifying familial hypercholesterolaemia in primary care: a retrospective cohort study (2020)
Journal Article
Akyea, R. K., Qureshi, N., Kai, J., de Lusignan, S., Sherlock, J., McGee, C., & Weng, S. (2020). Evaluating a clinical tool (FAMCAT) for identifying familial hypercholesterolaemia in primary care: a retrospective cohort study. BJGP Open, 4(5), 1-10. https://doi.org/10.3399/bjgpopen20X101114

Background: Familial hypercholesterolaemia (FH) is an inherited lipid disorder causing premature heart disease, which is severely underdiagnosed. Improving the identification of people with FH in primary care settings would help to reduce avoidable h... Read More about Evaluating a clinical tool (FAMCAT) for identifying familial hypercholesterolaemia in primary care: a retrospective cohort study.

Performance and clinical utility of supervised machine-learning approaches in detecting familial hypercholesterolaemia in primary care (2020)
Journal Article
Akyea, R. K., Qureshi, N., Kai, J., & Weng, S. F. (2020). Performance and clinical utility of supervised machine-learning approaches in detecting familial hypercholesterolaemia in primary care. npj Digital Medicine, 3(1), Article 142. https://doi.org/10.1038/s41746-020-00349-5

Familial hypercholesterolaemia (FH) is a common inherited disorder, causing lifelong elevated low-density lipoprotein cholesterol (LDL-C). Most individuals with FH remain undiagnosed, precluding opportunities to prevent premature heart disease and de... Read More about Performance and clinical utility of supervised machine-learning approaches in detecting familial hypercholesterolaemia in primary care.

Predicting major adverse cardiovascular events for secondary prevention: protocol for a systematic review and meta-analysis of risk prediction models (2020)
Journal Article
Akyea, R. K., Leonardi-Bee, J., Asselbergs, F. W., Patel, R. S., Durrington, P., Wierzbicki, A. S., …Weng, S. F. (2020). Predicting major adverse cardiovascular events for secondary prevention: protocol for a systematic review and meta-analysis of risk prediction models. BMJ Open, 10(7), Article e034564. https://doi.org/10.1136/bmjopen-2019-034564

Introduction: Cardiovascular disease (CVD) is the leading cause of morbidity and mortality globally. With advances in early diagnosis and treatment of CVD and increasing life expectancy, more people are surviving initial CVD events. However, models t... Read More about Predicting major adverse cardiovascular events for secondary prevention: protocol for a systematic review and meta-analysis of risk prediction models.

Is family history still underutilised? Exploring the views and experiences of primary care doctors in Malaysia (2020)
Journal Article
Hussein, N., Malik, T. F. A., Salim, H., Samad, A., Qureshi, N., & Ng, C. J. (2020). Is family history still underutilised? Exploring the views and experiences of primary care doctors in Malaysia. Journal of Community Genetics, 11(4), 413-420. https://doi.org/10.1007/s12687-020-00476-2

Family history has long been recognised as a non-invasive and inexpensive tool to identify individuals at risk of genetic conditions. Even in the era of evolving genetic and genomic technology, the role of family history in predicting individual risk... Read More about Is family history still underutilised? Exploring the views and experiences of primary care doctors in Malaysia.

What are the benefits and harms of risk stratified screening as part of the NHS breast screening Programme? Study protocol for a multi-site non-randomised comparison of BC-predict versus usual screening (NCT04359420) (2020)
Journal Article
French, D. P., Astley, S., Brentnall, A. R., Cuzick, J., Dobrashian, R., Duffy, S. W., …Evans, D. G. (2020). What are the benefits and harms of risk stratified screening as part of the NHS breast screening Programme? Study protocol for a multi-site non-randomised comparison of BC-predict versus usual screening (NCT04359420). BMC Cancer, 20, Article 570. https://doi.org/10.1186/s12885-020-07054-2

Background In principle, risk-stratification as a routine part of the NHS Breast Screening Programme (NHSBSP) should produce a better balance of benefits and harms. The main benefit is the offer of NICE-approved more frequent screening and/ or chemo... Read More about What are the benefits and harms of risk stratified screening as part of the NHS breast screening Programme? Study protocol for a multi-site non-randomised comparison of BC-predict versus usual screening (NCT04359420).

Improving primary care identification of familial breast cancer risk using proactive invitation and decision support (2020)
Journal Article
Qureshi, N., Dutton, B., Weng, S., Sheehan, C., Chorley, W., Robertson, J. F., …Kai, J. (2021). Improving primary care identification of familial breast cancer risk using proactive invitation and decision support. Familial Cancer, 20(1), 13-21. https://doi.org/10.1007/s10689-020-00188-z

Family history of breast cancer is a key risk factor, accounting for up to 10% of cancers. We evaluated the proactive assessment of familial breast cancer (FBC) risk in primary care. Eligible women (30 to 60 years) were recruited from eight English g... Read More about Improving primary care identification of familial breast cancer risk using proactive invitation and decision support.

Development and validation of the DIabetes Severity SCOre (DISSCO) in 139 626 individuals with type 2 diabetes: a retrospective cohort study (2020)
Journal Article
Zghebi, S. S., Mamas, M. A., Ashcroft, D. M., Salisbury, C., Mallen, C. D., Chew-Graham, C. A., …Kontopantelis, E. (2020). Development and validation of the DIabetes Severity SCOre (DISSCO) in 139 626 individuals with type 2 diabetes: a retrospective cohort study. BMJ Open Diabetes Research and Care, 8(1), Article e000962. https://doi.org/10.1136/bmjdrc-2019-000962

Objective: Clinically-applicable diabetes severity measures are lacking, with no previous studies compared their predictive value to HbA1c. We developed and validated a type 2 diabetes severity score (DISSCO) and evaluated its association with risks... Read More about Development and validation of the DIabetes Severity SCOre (DISSCO) in 139 626 individuals with type 2 diabetes: a retrospective cohort study.

Engagement barriers and service inequities in the NHS Breast Screening Programme: Views from British-Pakistani women (2019)
Journal Article
Woof, V. G., Ruane, H., Ulph, F., French, D. P., Qureshi, N., Khan, N., …Donnelly, L. S. (2020). Engagement barriers and service inequities in the NHS Breast Screening Programme: Views from British-Pakistani women. Journal of Medical Screening, 27(3), 130-137. https://doi.org/10.1177/0969141319887405

Objectives: Previous research has largely attempted to explore breast screening experiences of South Asian women by combining opinions from Pakistani, Bangladeshi and Indian women. This research often fails to reach the most underserved sub-groups of... Read More about Engagement barriers and service inequities in the NHS Breast Screening Programme: Views from British-Pakistani women.

HEART UK consensus statement on Lipoprotein(a): A call to action (2019)
Journal Article
Cegla, J., Neely, R. D. G., France, M., Ferns, G., Byrne, C. D., Halcox, J., …for the HEART UK Medical, Scientific and Research Committee. (2019). HEART UK consensus statement on Lipoprotein(a): A call to action. Atherosclerosis, 291, 62-70. https://doi.org/10.1016/j.atherosclerosis.2019.10.011

Lipoprotein(a), Lp(a), is a modified atherogenic low-density lipoprotein particle that contains apolipoprotein(a). Its levels are highly heritable and variable in the population. This consensus statement by HEART UK is based on the evidence that Lp(a... Read More about HEART UK consensus statement on Lipoprotein(a): A call to action.

How should health policy and practice respond to the increased genetic risk associated with close relative marriage? results of a UK Delphi consensus building exercise (2019)
Journal Article
Salway, S., Yazici, E., Khan, N., Ali, P., Elmslie, F., Thompson, J., & Qureshi, N. (2019). How should health policy and practice respond to the increased genetic risk associated with close relative marriage? results of a UK Delphi consensus building exercise. BMJ Open, 9(7), Article e028928. https://doi.org/10.1136/bmjopen-2019-028928

Objectives: (1) To explore professional and lay stakeholder views on the design and delivery of services in the area of consanguinity and genetic risk. (2) To identify principles on which there is sufficient consensus to warrant inclusion in a nation... Read More about How should health policy and practice respond to the increased genetic risk associated with close relative marriage? results of a UK Delphi consensus building exercise.

Risk of cardiovascular disease outcomes in primary care subjects with familial hypercholesterolaemia: A cohort study (2019)
Journal Article
Iyen, B., Qureshi, N., Leonardi-Bee, J., Kai, J., Akyea, R. K., Roderick, P., …Weng, S. (2019). Risk of cardiovascular disease outcomes in primary care subjects with familial hypercholesterolaemia: A cohort study. Atherosclerosis, 287, 8-15. https://doi.org/10.1016/j.atherosclerosis.2019.05.017

Background and aims: Familial hypercholesterolaemia (FH) is a known major cause of premature heart disease. However, the risks of atherosclerotic disease in other vascular regions are less known. We determined the risk of major cardiovascular disease... Read More about Risk of cardiovascular disease outcomes in primary care subjects with familial hypercholesterolaemia: A cohort study.

Effectiveness of interventions to identify and manage patients with familial cancer risk in primary care: a systematic review (2019)
Journal Article
Ing Lee, S., Patel, M., Dutton, B., Weng, S., Luveta, J., & Qureshi, N. (2019). Effectiveness of interventions to identify and manage patients with familial cancer risk in primary care: a systematic review. Journal of Community Genetics, https://doi.org/10.1007/s12687-019-00419-6

This systematic review evaluated the effectiveness of strategies to identify and manage patients with familial risk of breast, ovarian, colorectal and prostate cancer in primary careto improve clinical outcomes. MEDLINE, EMBASE, CINAHL and Cochrane l... Read More about Effectiveness of interventions to identify and manage patients with familial cancer risk in primary care: a systematic review.

Detection of familial hypercholesterolaemia: external validation of the FAMCAT clinical case-finding algorithm to identify patients in primary care (2019)
Journal Article
Weng, S., Kai, J., Akyea, R., & Qureshi, N. (2019). Detection of familial hypercholesterolaemia: external validation of the FAMCAT clinical case-finding algorithm to identify patients in primary care. Lancet Public Health, 4(5), e256-e264. https://doi.org/10.1016/S2468-2667%2819%2930061-1

Background: The vast majority of individuals with familial hypercholesterolaemia (FH) in the general population remain unidentified worldwide. Recognising patients most at risk of having the condition, to enable targeted specialist assessment and tre... Read More about Detection of familial hypercholesterolaemia: external validation of the FAMCAT clinical case-finding algorithm to identify patients in primary care.

Sub-optimal cholesterol response to initiation of statins and future risk of cardiovascular disease (2019)
Journal Article
Akyea, R., Kai, J., Qureshi, N., Iyen, B., & Weng, S. (2019). Sub-optimal cholesterol response to initiation of statins and future risk of cardiovascular disease. Heart, 105(13), 975-981. https://doi.org/10.1136/heartjnl-2018-314253

Objective: To assess low-density lipoprotein cholesterol (LDL-C) response in patients after initiation of statins, and future risk of CVD. Method: Prospective cohort study of 165,411 primary care patients, from the UK Clinical Practice Research... Read More about Sub-optimal cholesterol response to initiation of statins and future risk of cardiovascular disease.

Prediction of premature all-cause mortality: a prospective general population cohort study comparing machine-learning and standard epidemiological approaches (2019)
Journal Article
Weng, S. F., Vaz, L., Qureshi, N., & Kai, J. (2019). Prediction of premature all-cause mortality: a prospective general population cohort study comparing machine-learning and standard epidemiological approaches. PLoS ONE, 14(3), 1-22. https://doi.org/10.1371/journal.pone.0214365

Background: Prognostic modelling using standard methods is well-established, particularly for predicting risk of single diseases. Machine-learning may offer potential to explore outcomes of even greater complexity, such as premature death. This stud... Read More about Prediction of premature all-cause mortality: a prospective general population cohort study comparing machine-learning and standard epidemiological approaches.

Assessing the severity of Type 2 diabetes using clinical data-based measures: a systematic review (2019)
Journal Article
Zghebi, S. S., Panagioti, M., Rutter, M. K., Ashcroft, D. M., van Marwijk, H., Salisbury, C., …Kontopantelis, E. (2019). Assessing the severity of Type 2 diabetes using clinical data-based measures: a systematic review. Diabetic Medicine, 36(6), 688-701. https://doi.org/10.1111/dme.13905

Aims: To identify and critically appraise measures that use clinical data to grade the severity of Type 2 diabetes. Methods: We searched MEDLINE, Embase and PubMed between inception and June 2018. Studies reporting on clinical data?based diabetes?sp... Read More about Assessing the severity of Type 2 diabetes using clinical data-based measures: a systematic review.

Screening for familial hypercholesterolaemia in primary care: time for general practice to play its part (2018)
Journal Article
Brett, T., Qureshi, N., Gidding, S., & Watts, G. F. (2018). Screening for familial hypercholesterolaemia in primary care: time for general practice to play its part. Atherosclerosis, 277, 399-406. https://doi.org/10.1016/j.atherosclerosis.2018.08.019

Fifty per cent of first-degree relatives of index cases with familial hypercholesterolemia (FH) inherit the disorder. Despite cascade screening being the most cost-effective method for detecting new cases, only a minority of individuals with FH are c... Read More about Screening for familial hypercholesterolaemia in primary care: time for general practice to play its part.