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Screening for familial hypercholesterolaemia in primary care: time for general practice to play its part

Brett, Tim; Qureshi, Nadeem; Gidding, Samuel; Watts, Gerald F.


Tim Brett

Samuel Gidding

Gerald F. Watts


Fifty per cent of first-degree relatives of index cases with familial hypercholesterolemia (FH) inherit the disorder. Despite cascade screening being the most cost-effective method for detecting new cases, only a minority of individuals with FH are currently identified. Primary care is a key target area to increase identification of new index cases and initiate cascade screening, thereby finding close relatives of all probands. Increasing public and health professional awareness about FH is essential.
In the United Kingdom and in Australia, most of the population are reviewed by a General Practitioner (GP) at least once over a three-year period, offering opportunities to check for FH as part of routine clinical consultations. Such opportunistic approaches can be supplemented by systematically searching electronic health records with information technology tools that identify high risk patients. GPs can help investigate and implement results of this data retrieval.
Current evidence suggests that early detection of FH and cascade testing meet most of the criteria for a worthwhile screening program. Among heterozygous patients the long latent period before the expected onset of coronary artery disease provides an opportunity for initiating effective drug and lifestyle changes. The greatest challenge for primary care is to implement an efficacious model of care that incorporates sustainable identification and management pathways.


Brett, T., Qureshi, N., Gidding, S., & Watts, G. F. (2018). Screening for familial hypercholesterolaemia in primary care: time for general practice to play its part. Atherosclerosis, 277, 399-406.

Journal Article Type Article
Acceptance Date Aug 21, 2018
Online Publication Date Sep 28, 2018
Publication Date Oct 31, 2018
Deposit Date Nov 7, 2018
Publicly Available Date Sep 29, 2019
Journal Atherosclerosis
Print ISSN 0021-9150
Publisher Elsevier
Peer Reviewed Peer Reviewed
Volume 277
Pages 399-406
Public URL
Publisher URL
Additional Information This article is maintained by: Elsevier; Article Title: Screening for familial hypercholesterolaemia in primary care: Time for general practice to play its part; Journal Title: Atherosclerosis; CrossRef DOI link to publisher maintained version:; Content Type: article; Copyright: © 2018 Elsevier B.V. All rights reserved.