Outputs (95)

Lactic acid gel versus metronidazole for recurrent bacterial vaginosis in women aged 16 years and over: the VITA RCT (2022)
Journal Article
Armstrong-Buisseret, L., Brittain, C., Kai, J., David, M., Anstey Watkins, J., Ozolins, M., …Ross, J. D. (2022). Lactic acid gel versus metronidazole for recurrent bacterial vaginosis in women aged 16 years and over: the VITA RCT. Health Technology Assessment, 26(2), 1-170. https://doi.org/10.3310/ZZKH4176

BACKGROUND: Bacterial vaginosis is a common and distressing condition associated with serious comorbidities. Antibiotic treatment is usually clinically effective in the short term, but recurrence is common and side effects can occur. OBJECTIVES: The... Read More about Lactic acid gel versus metronidazole for recurrent bacterial vaginosis in women aged 16 years and over: the VITA RCT.

Prostate-specific antigen testing and opportunistic prostate cancer screening: a cohort study in England, 1998–2017 (2021)
Journal Article
Clift, A. K., Coupland, C. A., & Hippisley-Cox, J. (2021). Prostate-specific antigen testing and opportunistic prostate cancer screening: a cohort study in England, 1998–2017. British Journal of General Practice, 71(703), e157-e165. https://doi.org/10.3399/bjgp20X713957

Background: Prostate cancer is a leading cause of cancer-related death. Interpretation of results from trials of screening with prostate-specific antigen (PSA) are complex in terms of defining optimal prostate cancer screening policy.

Aims: Assess... Read More about Prostate-specific antigen testing and opportunistic prostate cancer screening: a cohort study in England, 1998–2017.

A study of mapping usual care and unmet need for vocational rehabilitation and psychological support following major trauma in five health districts in the UK (2020)
Journal Article
Kettlewell, J., Timmons, S., Bridger, K., Kendrick, D., Kellezi, B., Holmes, J., …Radford, K. (2021). A study of mapping usual care and unmet need for vocational rehabilitation and psychological support following major trauma in five health districts in the UK. Clinical Rehabilitation, 35(5), 750-764. https://doi.org/10.1177/0269215520971777

Objective: To identify where and how trauma survivors’ rehabilitation needs are met after trauma, to map rehabilitation across five UK major trauma networks, and to compare with recommended pathways. Design: Qualitative study (interviews, focus group... Read More about A study of mapping usual care and unmet need for vocational rehabilitation and psychological support following major trauma in five health districts in the UK.

Evaluating a clinical tool (FAMCAT) for identifying familial hypercholesterolaemia in primary care: a retrospective cohort study (2020)
Journal Article
Akyea, R. K., Qureshi, N., Kai, J., de Lusignan, S., Sherlock, J., McGee, C., & Weng, S. (2020). Evaluating a clinical tool (FAMCAT) for identifying familial hypercholesterolaemia in primary care: a retrospective cohort study. BJGP Open, 4(5), 1-10. https://doi.org/10.3399/bjgpopen20X101114

Background: Familial hypercholesterolaemia (FH) is an inherited lipid disorder causing premature heart disease, which is severely underdiagnosed. Improving the identification of people with FH in primary care settings would help to reduce avoidable h... Read More about Evaluating a clinical tool (FAMCAT) for identifying familial hypercholesterolaemia in primary care: a retrospective cohort study.

Performance and clinical utility of supervised machine-learning approaches in detecting familial hypercholesterolaemia in primary care (2020)
Journal Article
Akyea, R. K., Qureshi, N., Kai, J., & Weng, S. F. (2020). Performance and clinical utility of supervised machine-learning approaches in detecting familial hypercholesterolaemia in primary care. npj Digital Medicine, 3(1), Article 142. https://doi.org/10.1038/s41746-020-00349-5

Familial hypercholesterolaemia (FH) is a common inherited disorder, causing lifelong elevated low-density lipoprotein cholesterol (LDL-C). Most individuals with FH remain undiagnosed, precluding opportunities to prevent premature heart disease and de... Read More about Performance and clinical utility of supervised machine-learning approaches in detecting familial hypercholesterolaemia in primary care.

Evaluation of the effectiveness, implementation and cost-effectiveness of the Stay One Step Ahead home safety promotion intervention for pre-school children: a study protocol (2020)
Journal Article
Orton, E., Watson, M., Hayes, M., Patel, T., Jones, M., Coupland, C., …Kendrick, D. (2020). Evaluation of the effectiveness, implementation and cost-effectiveness of the Stay One Step Ahead home safety promotion intervention for pre-school children: a study protocol. Injury Prevention, 26(6), 573-580. https://doi.org/10.1136/injuryprev-2020-043877

Background: Unintentional injuries in children under the age of 5 years commonly occur in the home and disproportionately affect those living in disadvantaged circumstances. Targeted home safety promotion should be offered to families most at risk bu... Read More about Evaluation of the effectiveness, implementation and cost-effectiveness of the Stay One Step Ahead home safety promotion intervention for pre-school children: a study protocol.

An interview study to determine the experiences of cellulitis diagnosis amongst health care professionals in the UK (2020)
Journal Article
Patel, M., Lee, S., Levell, N., Smart, P., Kai, J., Thomas, K., & Leighton, P. (2020). An interview study to determine the experiences of cellulitis diagnosis amongst health care professionals in the UK. BMJ Open, 10, Article e034692. https://doi.org/10.1136/bmjopen-2019-034692

Objectives: To explore health care professionals (HCPs) experiences and challenges in diagnosing suspected lower limb cellulitis.

Setting: UK nationwide.

Participants: 20 qualified HCPs, who had a minimum of two years clinical experience as a... Read More about An interview study to determine the experiences of cellulitis diagnosis amongst health care professionals in the UK.

Over-The-Counter Codeine: Can Community Pharmacy Staff Nudge Customers into Its Safe and Appropriate Use? (2020)
Journal Article
Mody, S., Kirkdale, C. L., Thornley, T., Dickinson, A., Avery, A. J., Knaggs, R., …Bastable, R. (2020). Over-The-Counter Codeine: Can Community Pharmacy Staff Nudge Customers into Its Safe and Appropriate Use?. Pharmacy, 8(4), Article 185. https://doi.org/10.3390/pharmacy8040185

The misuse of opioids, including codeine which is sold over-the-counter (OTC) in United Kingdom (UK) community pharmacies, is a growing public health concern. An educational Patient Safety Card was developed and piloted to see if it nudged customers... Read More about Over-The-Counter Codeine: Can Community Pharmacy Staff Nudge Customers into Its Safe and Appropriate Use?.

Fetal safety of nicotine replacement therapy in pregnancy: systematic review and meta‐analysis (2020)
Journal Article
Taylor, L., Claire, R., Campbell, K., Coleman‐Haynes, T., Leonardi‐Bee, J., Chamberlain, C., …Coleman, T. (2021). Fetal safety of nicotine replacement therapy in pregnancy: systematic review and meta‐analysis. Addiction, 116(2), 239-277. https://doi.org/10.1111/add.15185

Background and aims: Smoking in pregnancy causes substantial avoidable harm to mothers and offspring; nicotine replacement therapy (NRT) may prevent this and is used to help women quit. A recently updated Cochrane review of randomised controlled tria... Read More about Fetal safety of nicotine replacement therapy in pregnancy: systematic review and meta‐analysis.

Mental health in the UK during the COVID-19 pandemic: cross-sectional analyses from a community cohort study (2020)
Journal Article
Jia, R., Ayling, K., Chalder, T., Massey, A., Broadbent, E., Coupland, C., & Vedhara, K. (2020). Mental health in the UK during the COVID-19 pandemic: cross-sectional analyses from a community cohort study. BMJ Open, 10(9), Article e040620. https://doi.org/10.1136/bmjopen-2020-040620

Objectives: Previous pandemics have resulted in significant consequences for mental health. Here, we report the mental health sequelae of the COVID-19 pandemic in a UK cohort and examine modifiable and non-modifiable explanatory factors associated wi... Read More about Mental health in the UK during the COVID-19 pandemic: cross-sectional analyses from a community cohort study.