All Outputs (1478)

Synthesis and Antibacterial Evaluation of New Pyrazolo[3,4-d]pyrimidines Kinase Inhibitors (2020)
Journal Article
Greco, C., Catania, R., Balacco, D. L., Taresco, V., Musumeci, F., Alexander, C., …Schenone, S. (2020). Synthesis and Antibacterial Evaluation of New Pyrazolo[3,4-d]pyrimidines Kinase Inhibitors. Molecules, 25(22), Article 5354. https://doi.org/10.3390/molecules25225354

Pyrazolo[3,4-d]pyrimidines represent an important class of heterocyclic compounds well-known for their anticancer activity exerted by the inhibition of eukaryotic protein kinases. Recently, pyrazolo[3,4-d]pyrimidines have become increasingly attracti... Read More about Synthesis and Antibacterial Evaluation of New Pyrazolo[3,4-d]pyrimidines Kinase Inhibitors.

Molecular Control of the Catalytic Properties of Rhodium Nanoparticles in Supported Ionic Liquid Phase (SILP) Systems (2020)
Journal Article
Bordet, A., Moos, G., Welsh, C., Licence, P., Luska, K. L., & Leitner, W. (2020). Molecular Control of the Catalytic Properties of Rhodium Nanoparticles in Supported Ionic Liquid Phase (SILP) Systems. ACS Catalysis, 10(23), 13904-13912. https://doi.org/10.1021/acscatal.0c03559

Rhodium nanoparticles (NPs) immobilized on imidazolium-based supported ionic liquid phases (Rh@SILP) act as effective catalysts for the hydrogenation of biomass-derived furfuralacetone. The structure of ionic liquid-type (IL) molecular modifiers was... Read More about Molecular Control of the Catalytic Properties of Rhodium Nanoparticles in Supported Ionic Liquid Phase (SILP) Systems.

Molecular Quantum Rings Formed from a π -Conjugated Macrocycle (2020)
Journal Article
Judd, C. J., Nizovtsev, A. S., Plougmann, R., Kondratuk, D. V., Anderson, H. L., Besley, E., & Saywell, A. (2020). Molecular Quantum Rings Formed from a π -Conjugated Macrocycle. Physical Review Letters, 125(20), Article 206803. https://doi.org/10.1103/PhysRevLett.125.206803

The electronic structure of a molecular quantum ring (stacks of 40-unit cyclic porphyrin polymers) is characterized via scanning tunneling microscopy and scanning tunneling spectroscopy. Our measurements access the energetic and spatial distribution... Read More about Molecular Quantum Rings Formed from a π -Conjugated Macrocycle.

Polymerisation-induced self-assembly (PISA) as a straightforward formulation strategy for stimuli-responsive drug delivery systems and biomaterials: recent advances (2020)
Journal Article
Phan, H., Taresco, V., Penelle, J., & Couturaud, B. (2021). Polymerisation-induced self-assembly (PISA) as a straightforward formulation strategy for stimuli-responsive drug delivery systems and biomaterials: recent advances. Biomaterials Science, 9(1), 38-50. https://doi.org/10.1039/d0bm01406k

Stimuli-responsive amphiphilic block copolymers have emerged as promising nanocarriers for enhancing site-specific and on-demand drug release in response to a range of stimuli such as pH, the presence of redox agents, and temperature. The formulation... Read More about Polymerisation-induced self-assembly (PISA) as a straightforward formulation strategy for stimuli-responsive drug delivery systems and biomaterials: recent advances.

Direct Imaging of Atomic Permeation Through a Vacancy Defect in the Carbon Lattice (2020)
Journal Article
Cao, K., Skowron, S. T., Stoppiello, C. T., Biskupek, J., Khlobystov, A. N., & Kaiser, U. (2020). Direct Imaging of Atomic Permeation Through a Vacancy Defect in the Carbon Lattice. Angewandte Chemie, 132(51), 23122-23127. https://doi.org/10.1002/ange.202010630

Porous graphene has shown promise as a new generation of selective membrane for sieving atoms, ions and molecules. However, the atomistic mechanisms of permeation through defects in the graphenic lattice are still unclear and remain unobserved in act... Read More about Direct Imaging of Atomic Permeation Through a Vacancy Defect in the Carbon Lattice.

Direct Imaging of Atomic Permeation Through a Vacancy Defect in the Carbon Lattice (2020)
Journal Article
Cao, K., Skowron, S. T., Stoppiello, C. T., Biskupek, J., Khlobystov, A. N., & Kaiser, U. (2020). Direct Imaging of Atomic Permeation Through a Vacancy Defect in the Carbon Lattice. Angewandte Chemie International Edition, 59(51), 22922-22927. https://doi.org/10.1002/anie.202010630

Porous graphene has shown promise as a new generation of selective membrane for sieving atoms, ions and molecules. However, the atomistic mechanisms of permeation through defects in the graphenic lattice are still unclear and remain unobserved in act... Read More about Direct Imaging of Atomic Permeation Through a Vacancy Defect in the Carbon Lattice.

Structural characterisation of molecular conformation and the incorporation of adatoms in an on-surface Ullmann-type reaction (2020)
Journal Article
Judd, C. J., Junqueira, F. L. Q., Haddow, S. L., Champness, N. R., Duncan, D. A., Jones, R. G., & Saywell, A. (2020). Structural characterisation of molecular conformation and the incorporation of adatoms in an on-surface Ullmann-type reaction. Communications Chemistry, 3(1), Article 166. https://doi.org/10.1038/s42004-020-00402-0

© 2020, The Author(s). The on-surface synthesis of covalently bonded materials differs from solution-phase synthesis in several respects. The transition from a three-dimensional reaction volume to quasi-two-dimensional confinement, as is the case for... Read More about Structural characterisation of molecular conformation and the incorporation of adatoms in an on-surface Ullmann-type reaction.

Origin of Selectivity in Protein Hydrolysis by Zr(IV)-Containing Metal Oxides as Artificial Proteases (2020)
Journal Article
Solé-Daura, A., Rodríguez-Fortea, A., Poblet, J. M., Robinson, D., Hirst, J. D., & Carbó, J. J. (2020). Origin of Selectivity in Protein Hydrolysis by Zr(IV)-Containing Metal Oxides as Artificial Proteases. ACS Catalysis, 10, 13455-13467. https://doi.org/10.1021/acscatal.0c02848

© 2020 American Chemical Society. All rights reserved. The origin of selectivity in protein hydrolysis promoted by Zr(IV)-substituted polyoxometalates (POMs) has been investigated through a variety of computational techniques. Initially, we analyzed... Read More about Origin of Selectivity in Protein Hydrolysis by Zr(IV)-Containing Metal Oxides as Artificial Proteases.

A Machine Learning Protocol for Predicting Protein Infrared Spectra (2020)
Journal Article
Ye, S., Zhong, K., Zhang, J., Hu, W., Hirst, J. D., Zhang, G., …Jiang, J. (2020). A Machine Learning Protocol for Predicting Protein Infrared Spectra. Journal of the American Chemical Society, 142(45), 19071–19077. https://doi.org/10.1021/jacs.0c06530

© 2020 American Chemical Society. Infrared (IR) absorption provides important chemical fingerprints of biomolecules. Protein secondary structure determination from IR spectra is tedious since its theoretical interpretation requires repeated expensive... Read More about A Machine Learning Protocol for Predicting Protein Infrared Spectra.

Porous carbons from sustainable sources and mild activation for targeted high-performance CO2 capture and storage (2020)
Journal Article
Aljumialy, A. M., & Mokaya, R. (2020). Porous carbons from sustainable sources and mild activation for targeted high-performance CO2 capture and storage. Materials Advances, 1(9), 3267-3280. https://doi.org/10.1039/d0ma00449a

Carbon activation typically involves corrosive activating reagents such as KOH and NaOH. In this report, a less corrosive activating agent, i.e., potassium oxalate (PO), was explored for the preparation of activated carbons from biomass (hydrochar fr... Read More about Porous carbons from sustainable sources and mild activation for targeted high-performance CO2 capture and storage.

Inter-Flake Quantum Transport of Electrons and Holes in Inkjet-Printed Graphene Devices (2020)
Journal Article
Wang, F., Gosling, J. H., Rance, G. A., Trindade, G. F., Makarovsky, O., Cottam, N. D., …Turyanska, L. (2021). Inter-Flake Quantum Transport of Electrons and Holes in Inkjet-Printed Graphene Devices. Advanced Functional Materials, 31(5), Article 2007478. https://doi.org/10.1002/adfm.202007478

© 2020 The Authors. Advanced Functional Materials published by Wiley-VCH GmbH 2D materials have unique structural and electronic properties with potential for transformative device applications. However, such devices are usually bespoke structures ma... Read More about Inter-Flake Quantum Transport of Electrons and Holes in Inkjet-Printed Graphene Devices.

Thermolysis of Organofluoroborate Ionic Liquids to NHC-Organofluoroborates (2020)
Journal Article
Clarke, C. J., Richardson, N., Firth, A. E., Hallett, J. P., & Licence, P. (2020). Thermolysis of Organofluoroborate Ionic Liquids to NHC-Organofluoroborates. ACS Sustainable Chemistry and Engineering, 8(44), 16386–16390. https://doi.org/10.1021/acssuschemeng.0c06377

A range of dialkylimidazolium organotrifluoroborate ionic liquids were prepared by anion metathesis from newly available potassium organotrifluoroborate salts, and their physical properties were characterized by TGA, DSC, and STA. Thermal decompositi... Read More about Thermolysis of Organofluoroborate Ionic Liquids to NHC-Organofluoroborates.

Decoding Protein Gas?Phase Stability with Alanine Scanning and Collision?Induced Unfolding Ion Mobility Mass Spectrometry (2020)
Journal Article
Bellamy?Carter, J., O'Grady, L., Passmore, M., Jenner, M., & Oldham, N. J. (2021). Decoding Protein Gas?Phase Stability with Alanine Scanning and Collision?Induced Unfolding Ion Mobility Mass Spectrometry. Analysis & Sensing, 1(1), 63-69. https://doi.org/10.1002/anse.202000019

Native mass spectrometry is a widely used tool in structural biology, providing information on protein structure and interactions through preservation of complexes in the gas phase. Herein, the importance of intramolecular non?covalent interactions i... Read More about Decoding Protein Gas?Phase Stability with Alanine Scanning and Collision?Induced Unfolding Ion Mobility Mass Spectrometry.

Amylose/cellulose nanofiber composites for all-natural, fully biodegradable and flexible bioplastics (2020)
Journal Article
Xu, J., Sagnelli, D., Faisal, M., Perzon, A., Taresco, V., Mais, M., …Blennow, A. (2021). Amylose/cellulose nanofiber composites for all-natural, fully biodegradable and flexible bioplastics. Carbohydrate Polymers, 253, Article 117277. https://doi.org/10.1016/j.carbpol.2020.117277

Thermoplastic, polysaccharide-based plastics are environmentally friendly. However, typical shortcomings include lack of water resistance and poor mechanical properties. Nanocomposite manufacturing using pure, highly linear, polysaccharides can overc... Read More about Amylose/cellulose nanofiber composites for all-natural, fully biodegradable and flexible bioplastics.

Photoelectron angular distributions from resonant two-photon ionization of adiabatically aligned naphthalene and aniline molecules (2020)
Journal Article
Arlt, J., Singh, D. P., Thompson, J. O., Chatterley, A. S., Hockett, P., Stapelfeldt, H., & Reid, K. L. (2021). Photoelectron angular distributions from resonant two-photon ionization of adiabatically aligned naphthalene and aniline molecules. Molecular Physics, 119(1-2), Article e1836411. https://doi.org/10.1080/00268976.2020.1836411

Photoelectron images have been measured following the ionisation of aligned distributions of gas phase naphthalene and aniline molecules. Alignment in the adiabatic regime was achieved by interaction with a 100?ps infrared laser pulse, with ionisatio... Read More about Photoelectron angular distributions from resonant two-photon ionization of adiabatically aligned naphthalene and aniline molecules.

Site‐Selective Modification of Peptides and Proteins via Interception of Free‐Radical‐Mediated Dechalcogenation (2020)
Journal Article
Griffiths, R. C., Smith, F. R., Long, J. E., Williams, H. E. L., Layfield, R., & Mitchell, N. J. (2020). Site‐Selective Modification of Peptides and Proteins via Interception of Free‐Radical‐Mediated Dechalcogenation. Angewandte Chemie, 132(52), 23867-23875. https://doi.org/10.1002/ange.202006260

The development of site-selective chemistry targeting the canonical amino acids enables the controlled installation of desired functionalities into native peptides and proteins. Such techniques facilitate the development of polypeptide conjugates to... Read More about Site‐Selective Modification of Peptides and Proteins via Interception of Free‐Radical‐Mediated Dechalcogenation.

Thin film synthesis of hybrid ultramicroporous materials (HUMs)- a comparative approach (2020)
Journal Article
Warfsmann, J., Tokay, B., & Champness, N. R. (2021). Thin film synthesis of hybrid ultramicroporous materials (HUMs)- a comparative approach. Microporous and Mesoporous Materials, 311, Article 110686. https://doi.org/10.1016/j.micromeso.2020.110686

© 2020 The thin-film synthesis of the hybrid ultramicroporous material (HUM) TIFSIX-3-Ni on glass substrates are reported for the first time. Several methods of film formation are employed including dip-coating, seeding and secondary growth, vapour-a... Read More about Thin film synthesis of hybrid ultramicroporous materials (HUMs)- a comparative approach.

Etoposide and olaparib polymer-coated nanoparticles within a bioadhesive sprayable hydrogel for post-surgical localised delivery to brain tumours (2020)
Journal Article
McCrorie, P., Mistry, J., Taresco, V., Lovato, T., Fay, M., Ward, I., …Rahman, R. (2020). Etoposide and olaparib polymer-coated nanoparticles within a bioadhesive sprayable hydrogel for post-surgical localised delivery to brain tumours. European Journal of Pharmaceutics and Biopharmaceutics, 157, 108-120. https://doi.org/10.1016/j.ejpb.2020.10.005

Glioblastoma is a malignant brain tumour with a median survival of 14.6 months from diagnosis. Despite maximal surgical resection and concurrent chemoradiotherapy, reoccurrence is inevitable. To try combating the disease at a stage of low residual tu... Read More about Etoposide and olaparib polymer-coated nanoparticles within a bioadhesive sprayable hydrogel for post-surgical localised delivery to brain tumours.

Porous Metal–Organic Polyhedra: Morphology, Porosity, and Guest Binding (2020)
Journal Article
Argent, S. P., Da Silva, I., Greenaway, A., Savage, M., Humby, J., Davies, A. J., …Schröder, M. (2020). Porous Metal–Organic Polyhedra: Morphology, Porosity, and Guest Binding. Inorganic Chemistry, 59(21), 15646-15658. https://doi.org/10.1021/acs.inorgchem.0c01935

Designing porous materials which can selectively adsorb CO2 or CH4 is an important environmental and industrial goal which requires an understanding of the host-guest interactions involved at the atomic scale. Metal-organic polyhedra (MOPs) showing p... Read More about Porous Metal–Organic Polyhedra: Morphology, Porosity, and Guest Binding.

Selection of potential molecular markers for cheese ripening and quality prediction by NMR spectroscopy (2020)
Journal Article
Chen, Y., MacNaughtan, W., Jones, P., Yang, Q., Williams, H., & Foster, T. (2021). Selection of potential molecular markers for cheese ripening and quality prediction by NMR spectroscopy. LWT - Food Science and Technology, 136, Article 110306. https://doi.org/10.1016/j.lwt.2020.110306

© 2020 Elsevier Ltd Predicting cheese quality as early as possible after ripening is important for quality control in the cheese industry. The main aim of this study was to investigate potential metabolites for predictive models of Cheddar cheese qua... Read More about Selection of potential molecular markers for cheese ripening and quality prediction by NMR spectroscopy.