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Synthesis and Antibacterial Evaluation of New Pyrazolo[3,4-d]pyrimidines Kinase Inhibitors

Greco, Chiara; Catania, Rosa; Balacco, Dario Leonardo; Taresco, Vincenzo; Musumeci, Francesca; Alexander, Cameron; Huett, Alan; Schenone, Silvia

Synthesis and Antibacterial Evaluation of New Pyrazolo[3,4-d]pyrimidines Kinase Inhibitors Thumbnail


Authors

Chiara Greco

Rosa Catania

Dario Leonardo Balacco

Francesca Musumeci

ALAN HUETT Alan.Huett@nottingham.ac.uk
Assistant Professor

Silvia Schenone



Contributors

Chiara Greco
Researcher

Rosa Catania
Researcher

Dario Leonardo Balacco
Researcher

Francesca Musumeci
Researcher

ALAN HUETT Alan.Huett@nottingham.ac.uk
Project Leader

Silvia Schenone
Project Leader

Abstract

Pyrazolo[3,4-d]pyrimidines represent an important class of heterocyclic compounds well-known for their anticancer activity exerted by the inhibition of eukaryotic protein kinases. Recently, pyrazolo[3,4-d]pyrimidines have become increasingly attractive for their potential antimicrobial properties. Here, we explored the activity of a library of in-house pyrazolo[3,4-d]pyrimidines, targeting human protein kinases, against Staphylococcus aureus and Escherichia coli and their interaction with ampicillin and kanamycin, representing important classes of clinically used antibiotics. Our results represent a first step towards the potential application of dual active pyrazolo[3,4-d]pyrimidine kinase inhibitors in the prevention and treatment of bacterial infections in cancer patients.

Citation

Greco, C., Catania, R., Balacco, D. L., Taresco, V., Musumeci, F., Alexander, C., …Schenone, S. (2020). Synthesis and Antibacterial Evaluation of New Pyrazolo[3,4-d]pyrimidines Kinase Inhibitors. Molecules, 25(22), Article 5354. https://doi.org/10.3390/molecules25225354

Journal Article Type Article
Acceptance Date Nov 9, 2020
Online Publication Date Nov 16, 2020
Publication Date Nov 16, 2020
Deposit Date Nov 17, 2020
Publicly Available Date Mar 29, 2024
Journal Molecules (Basel, Switzerland)
Electronic ISSN 1420-3049
Publisher MDPI
Peer Reviewed Peer Reviewed
Volume 25
Issue 22
Article Number 5354
DOI https://doi.org/10.3390/molecules25225354
Keywords Organic Chemistry
Public URL https://nottingham-repository.worktribe.com/output/5048891
Publisher URL https://www.mdpi.com/1420-3049/25/22/5354

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