Chiara Greco
Synthesis and Antibacterial Evaluation of New Pyrazolo[3,4-d]pyrimidines Kinase Inhibitors
Greco, Chiara; Catania, Rosa; Balacco, Dario Leonardo; Taresco, Vincenzo; Musumeci, Francesca; Alexander, Cameron; Huett, Alan; Schenone, Silvia
Authors
Rosa Catania
Dario Leonardo Balacco
VINCENZO TARESCO VINCENZO.TARESCO@NOTTINGHAM.AC.UK
Nottingham Research Fellow
Francesca Musumeci
Professor CAMERON ALEXANDER CAMERON.ALEXANDER@NOTTINGHAM.AC.UK
Professor of Polymer Therapeutics
ALAN HUETT Alan.Huett@nottingham.ac.uk
Assistant Professor
Silvia Schenone
Contributors
Chiara Greco
Researcher
Rosa Catania
Researcher
Dario Leonardo Balacco
Researcher
VINCENZO TARESCO VINCENZO.TARESCO@NOTTINGHAM.AC.UK
Researcher
Francesca Musumeci
Researcher
Professor CAMERON ALEXANDER CAMERON.ALEXANDER@NOTTINGHAM.AC.UK
Project Leader
ALAN HUETT Alan.Huett@nottingham.ac.uk
Project Leader
Silvia Schenone
Project Leader
Abstract
Pyrazolo[3,4-d]pyrimidines represent an important class of heterocyclic compounds well-known for their anticancer activity exerted by the inhibition of eukaryotic protein kinases. Recently, pyrazolo[3,4-d]pyrimidines have become increasingly attractive for their potential antimicrobial properties. Here, we explored the activity of a library of in-house pyrazolo[3,4-d]pyrimidines, targeting human protein kinases, against Staphylococcus aureus and Escherichia coli and their interaction with ampicillin and kanamycin, representing important classes of clinically used antibiotics. Our results represent a first step towards the potential application of dual active pyrazolo[3,4-d]pyrimidine kinase inhibitors in the prevention and treatment of bacterial infections in cancer patients.
Citation
Greco, C., Catania, R., Balacco, D. L., Taresco, V., Musumeci, F., Alexander, C., …Schenone, S. (2020). Synthesis and Antibacterial Evaluation of New Pyrazolo[3,4-d]pyrimidines Kinase Inhibitors. Molecules, 25(22), Article 5354. https://doi.org/10.3390/molecules25225354
Journal Article Type | Article |
---|---|
Acceptance Date | Nov 9, 2020 |
Online Publication Date | Nov 16, 2020 |
Publication Date | Nov 16, 2020 |
Deposit Date | Nov 17, 2020 |
Publicly Available Date | Nov 17, 2020 |
Journal | Molecules (Basel, Switzerland) |
Electronic ISSN | 1420-3049 |
Publisher | MDPI |
Peer Reviewed | Peer Reviewed |
Volume | 25 |
Issue | 22 |
Article Number | 5354 |
DOI | https://doi.org/10.3390/molecules25225354 |
Keywords | Organic Chemistry |
Public URL | https://nottingham-repository.worktribe.com/output/5048891 |
Publisher URL | https://www.mdpi.com/1420-3049/25/22/5354 |
Files
Synthesis and Antibacterial Evaluation
(2.9 Mb)
PDF
Publisher Licence URL
https://creativecommons.org/licenses/by/4.0/
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