All Outputs (1488)

Enabling high-fidelity personalised pharmaceutical tablets through multimaterial inkjet 3D printing with a water-soluble excipient (2024)
Journal Article

Additive manufacturing offers manufacture of personalised pharmaceutical tablets through design freedoms and material deposition control at an individual voxel level. This control goes beyond geometry and materials choices: inkjet based 3D printing e... Read More about Enabling high-fidelity personalised pharmaceutical tablets through multimaterial inkjet 3D printing with a water-soluble excipient.

Enantioselective de novo synthesis of 14-hydroxy-6-oxomorphinans (2024)
Journal Article

The enantioselective de novo synthesis of pharmacologically important 14-hydroxy-6-oxomorphinans is described. 4,5-Desoxynaltrexone and 4,5-desoxynaloxone were prepared using this route and their biological activities against the opioid receptors wer... Read More about Enantioselective de novo synthesis of 14-hydroxy-6-oxomorphinans.

Synthesis, anti-diabetic profiling and molecular docking studies of 2-(2- arylidenehydrazinyl)thiazol-4(5H)-ones (2024)
Journal Article

Aims: To synthesize novel more potent anti-diabetic agents. Methodology: A simple cost effective Hantzsch's synthetic strategy was used to synthesize 2-(2-arylidenehydrazinyl)thiazol-4(5H)-ones. Results: Fifteen new 2-(2-arylidenehydrazinyl)thiazol-4... Read More about Synthesis, anti-diabetic profiling and molecular docking studies of 2-(2- arylidenehydrazinyl)thiazol-4(5H)-ones.

Process Intensification of the Continuous Synthesis of Bio-Derived Monomers for Sustainable Coatings Using a Taylor Vortex Flow Reactor (2024)
Journal Article

We describe the optimization and scale-up of two consecutive reaction steps in the synthesis of bio-derived alkoxybutenolide monomers that have been reported as potential replacements for acrylate-based coatings ( Sci. Adv. 2020, 6, eabe0026). These... Read More about Process Intensification of the Continuous Synthesis of Bio-Derived Monomers for Sustainable Coatings Using a Taylor Vortex Flow Reactor.

Machine learning insights into predicting biogas separation in metal-organic frameworks (2024)
Journal Article

Breakthroughs in efficient use of biogas fuel depend on successful separation of carbon dioxide/methane streams and identification of appropriate separation materials. In this work, machine learning models are trained to predict biogas separation pro... Read More about Machine learning insights into predicting biogas separation in metal-organic frameworks.

Fluid-rock interaction experiments with andesite at 100°C for potential carbon storage in geothermal reservoirs (2024)
Journal Article

Geothermal energy extraction often results in the release of naturally occurring carbon dioxide (CO2) as a byproduct. Research on carbon storage using volcanic rock types other than basalt under both acidic and elevated temperature conditions has bee... Read More about Fluid-rock interaction experiments with andesite at 100°C for potential carbon storage in geothermal reservoirs.

Strain-modulated defect engineering of two-dimensional materials (2024)
Journal Article

Strain- and defect-engineering are two powerful approaches to tailor the opto-electronic properties of two-dimensional (2D) materials, but the relationship between applied mechanical strain and behavior of defects in these systems remains elusive. Us... Read More about Strain-modulated defect engineering of two-dimensional materials.

Mechanistic investigations of the Fe(ii) mediated synthesis of squaraines (2024)
Journal Article

The scission and homologation of CO is a fundamental process in the Fischer–Tropsch reaction. However, given the heterogeneous nature of the catalyst and forcing reaction conditions, it is difficult to determine the intermediates of this reaction. He... Read More about Mechanistic investigations of the Fe(ii) mediated synthesis of squaraines.

Multiple drug-delivery strategies to enhance the pharmacological and toxicological properties of Mefenamic acid (2024)
Journal Article

Objective: To improve the biological and toxicological properties of Mefenamic acid (MA), the galactosylated prodrug of MA named MefeGAL was included in polymeric solid dispersions (PSs) composed of poly(glycerol adipate) (PGA) and Pluronic® F68 (Mef... Read More about Multiple drug-delivery strategies to enhance the pharmacological and toxicological properties of Mefenamic acid.

Simultaneous geraniol and citronellol transesterification using Pseudomonas fluorescens lipase for the production of fragrance and flavour esters: a kinetic study (2024)
Journal Article

This study aims to develop, for the very first time, a kinetic model for the simultaneous transesterification of geraniol and citronellol using Pseudomonas fluorescens lipase to produce their respective esters. This allows us to test the feasibility... Read More about Simultaneous geraniol and citronellol transesterification using Pseudomonas fluorescens lipase for the production of fragrance and flavour esters: a kinetic study.

Symmetry and reactivity of π-systems in electric and magnetic fields: a perspective from conceptual DFT (2024)
Journal Article

The extension of conceptual density-functional theory (conceptual DFT) to include external electromagnetic fields in chemical systems is utilised to investigate the effects of strong magnetic fields on the electronic charge distribution and its conse... Read More about Symmetry and reactivity of π-systems in electric and magnetic fields: a perspective from conceptual DFT.

Encapsulation of copper phenanthroline within horse spleen apoferritin: characterisation, cytotoxic activity and ability to retain temozolomide (2024)
Journal Article

Protein capsules are promising drug delivery vehicles for cancer research therapies. Apoferritin (AFt) is a self-assembling 12 nm diameter hollow nanocage with many desirable features for drug delivery, however, control of drug retention inside the p... Read More about Encapsulation of copper phenanthroline within horse spleen apoferritin: characterisation, cytotoxic activity and ability to retain temozolomide.

Synthesis and Structural Studies of peri-Substituted Acenaphthenes with Tertiary Phosphine and Stibine Groups (2024)
Journal Article

Two mixed peri-substituted phosphine-chlorostibines, Acenap(PiPr2)(SbPhCl) and Acenap(PiPr2)(SbCl2) (Acenap = acenaphthene-5,6-diyl) reacted cleanly with Grignard reagents or nBuLi to give the corresponding tertiary phosphine-stibines Acenap(PiPr2)(S... Read More about Synthesis and Structural Studies of peri-Substituted Acenaphthenes with Tertiary Phosphine and Stibine Groups.

From scrap metal to highly efficient electrodes: harnessing the nanotextured surface of swarf for effective utilisation of Pt and Co for hydrogen production (2024)
Journal Article

Hydrogen is considered to be the key element to achieving climate neutrality, leading to a massive demand for electrocatalysts. This work explores the transformation of metal waste into active and stable electrode materials for water splitting by mod... Read More about From scrap metal to highly efficient electrodes: harnessing the nanotextured surface of swarf for effective utilisation of Pt and Co for hydrogen production.

A facile one step route that introduces functionality to polymer powders for laser sintering (2024)
Journal Article

Laser Sintering (LS) is a type of Additive Manufacturing (AM) exploiting laser processing of polymeric particles to produce 3D objects. Because of its ease of processability and thermo-physical properties, polyamide-12 (PA-12) represents ~95% of the... Read More about A facile one step route that introduces functionality to polymer powders for laser sintering.

Unravelling the complex speciation of halozincate ionic liquids using X-ray spectroscopies and calculations (2024)
Journal Article

Using a combination of liquid-phase experimental X-ray spectroscopy experiments and small-scale calculations we have gained new insights into the speciation of halozincate anions in ionic liquids (ILs). Both core and valence X-ray photoelectron spect... Read More about Unravelling the complex speciation of halozincate ionic liquids using X-ray spectroscopies and calculations.

Beyond Acetylene: Exploring Solvent Stabilization of Calcium Carbide‐derived Acetylide Intermediates and Their Significance in Small Organic Molecule Synthesis (2024)
Journal Article

The reaction of calcium carbide with water has been widely used as a source of acetylene for the synthesis of organic molecules. In contrast with this traditional approach, we use the CaC2 reaction under water-starved conditions and show reactions th... Read More about Beyond Acetylene: Exploring Solvent Stabilization of Calcium Carbide‐derived Acetylide Intermediates and Their Significance in Small Organic Molecule Synthesis.

Modulated Self-Assembly of Catalytically Active Metal–Organic Nanosheets Containing Zr6 Clusters and Dicarboxylate Ligands (2024)
Journal Article

Two-dimensional metal–organic nanosheets (MONs) have emerged as attractive alternatives to their three-dimensional metal–organic framework (MOF) counterparts for heterogeneous catalysis due to their greater external surface areas and higher accessibi... Read More about Modulated Self-Assembly of Catalytically Active Metal–Organic Nanosheets Containing Zr6 Clusters and Dicarboxylate Ligands.

Co-delivery of curcumin and resveratrol by folic acid-conjugated poly(glycerol adipate) nanoparticles for enhanced synergistic anticancer effect against osteosarcoma (2024)
Journal Article

This study explored the co-delivery of curcumin (CUR) and resveratrol (RV) using folic acid-conjugated poly(glycerol adipate)-based nanoparticles (FPPC NPs) to enhance their synergistic anticancer effects against osteosarcoma. Based on synergistic to... Read More about Co-delivery of curcumin and resveratrol by folic acid-conjugated poly(glycerol adipate) nanoparticles for enhanced synergistic anticancer effect against osteosarcoma.

Discovery of novel SOS1 inhibitors using machine learning (2024)
Journal Article

Overactivation of the rat sarcoma virus (RAS) signaling is responsible for 30% of all human malignancies. Son of sevenless 1 (SOS1), a crucial node in the RAS signaling pathway, could modulate RAS activation, offering a promising therapeutic strategy... Read More about Discovery of novel SOS1 inhibitors using machine learning.