Amaraporn Wongrakpanich
Co-delivery of curcumin and resveratrol by folic acid-conjugated poly(glycerol adipate) nanoparticles for enhanced synergistic anticancer effect against osteosarcoma
Wongrakpanich, Amaraporn; Bui Thi Thu, Huong; Sakchaisri, Krisada; Taresco, Vincenzo; Cuzzucoli Crucitti, Valentina; Bunsupa, Somnuk; Suksiriworapong, Jiraphong
Authors
Huong Bui Thi Thu
Krisada Sakchaisri
Dr VINCENZO TARESCO VINCENZO.TARESCO@NOTTINGHAM.AC.UK
NOTTINGHAM RESEARCH FELLOW
Dr VALENTINA CUZZUCOLI CRUCITTI VALENTINA.CUZZUCOLICRUCITTI1@NOTTINGHAM.AC.UK
RESEARCH FELLOW
Somnuk Bunsupa
Jiraphong Suksiriworapong
Abstract
This study explored the co-delivery of curcumin (CUR) and resveratrol (RV) using folic acid-conjugated poly(glycerol adipate)-based nanoparticles (FPPC NPs) to enhance their synergistic anticancer effects against osteosarcoma. Based on synergistic toxicity experiments against Saos-2 cells, the optimal synergistic CUR:RV ratios were 1:2 and 1:3, which were used for co-encapsulation. Increasing the amount of RV in the co-loaded NPs did not affect the properties of the nanocarriers, but predominantly increased the loading capacity of RV, especially at the 1:3 ratio, by 1.8–2.0 times, mediated by their interaction. All co-loaded NPs demonstrated sustained release of CUR with a burst release of RV, and the presence of RV accelerated the initial release of CUR from the carriers. Furthermore, the co-encapsulated NPs maintained CUR and RV synergism and greatly enhanced their toxicity against osteosarcoma by at least 1.8 times compared to their corresponding solutions through profound accumulation of Saos-2 cells in the sub G1 phase and late apoptosis. The internalization of FPPC NPs into cells via endocytosis was dose- and time-dependent. This study offers a proof-of-concept for a potential co-delivery system using tumor-targeted poly(glycerol adipate)-based NPs to enhance the anticancer activity of CUR and RV against osteosarcoma.
Citation
Wongrakpanich, A., Bui Thi Thu, H., Sakchaisri, K., Taresco, V., Cuzzucoli Crucitti, V., Bunsupa, S., & Suksiriworapong, J. (2024). Co-delivery of curcumin and resveratrol by folic acid-conjugated poly(glycerol adipate) nanoparticles for enhanced synergistic anticancer effect against osteosarcoma. Journal of Drug Delivery Science and Technology, 95, Article 105610. https://doi.org/10.1016/j.jddst.2024.105610
Journal Article Type | Article |
---|---|
Acceptance Date | Mar 22, 2024 |
Online Publication Date | Mar 23, 2024 |
Publication Date | 2024-05 |
Deposit Date | Mar 30, 2024 |
Publicly Available Date | Apr 5, 2024 |
Journal | Journal of Drug Delivery Science and Technology |
Print ISSN | 1773-2247 |
Electronic ISSN | 1773-2247 |
Publisher | Elsevier |
Peer Reviewed | Peer Reviewed |
Volume | 95 |
Article Number | 105610 |
DOI | https://doi.org/10.1016/j.jddst.2024.105610 |
Keywords | Curcumin, Resveratrol, Nanoparticle, Osteosarcoma, Co-delivery, Synergistic |
Public URL | https://nottingham-repository.worktribe.com/output/33027810 |
Files
1-s2.0-S177322472400279X-main
(9.8 Mb)
PDF
Publisher Licence URL
https://creativecommons.org/licenses/by-nc-nd/4.0/
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