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Co-delivery of curcumin and resveratrol by folic acid-conjugated poly(glycerol adipate) nanoparticles for enhanced synergistic anticancer effect against osteosarcoma

Wongrakpanich, Amaraporn; Bui Thi Thu, Huong; Sakchaisri, Krisada; Taresco, Vincenzo; Cuzzucoli Crucitti, Valentina; Bunsupa, Somnuk; Suksiriworapong, Jiraphong

Co-delivery of curcumin and resveratrol by folic acid-conjugated poly(glycerol adipate) nanoparticles for enhanced synergistic anticancer effect against osteosarcoma Thumbnail


Authors

Amaraporn Wongrakpanich

Huong Bui Thi Thu

Krisada Sakchaisri

Somnuk Bunsupa

Jiraphong Suksiriworapong



Abstract

This study explored the co-delivery of curcumin (CUR) and resveratrol (RV) using folic acid-conjugated poly(glycerol adipate)-based nanoparticles (FPPC NPs) to enhance their synergistic anticancer effects against osteosarcoma. Based on synergistic toxicity experiments against Saos-2 cells, the optimal synergistic CUR:RV ratios were 1:2 and 1:3, which were used for co-encapsulation. Increasing the amount of RV in the co-loaded NPs did not affect the properties of the nanocarriers, but predominantly increased the loading capacity of RV, especially at the 1:3 ratio, by 1.8–2.0 times, mediated by their interaction. All co-loaded NPs demonstrated sustained release of CUR with a burst release of RV, and the presence of RV accelerated the initial release of CUR from the carriers. Furthermore, the co-encapsulated NPs maintained CUR and RV synergism and greatly enhanced their toxicity against osteosarcoma by at least 1.8 times compared to their corresponding solutions through profound accumulation of Saos-2 cells in the sub G1 phase and late apoptosis. The internalization of FPPC NPs into cells via endocytosis was dose- and time-dependent. This study offers a proof-of-concept for a potential co-delivery system using tumor-targeted poly(glycerol adipate)-based NPs to enhance the anticancer activity of CUR and RV against osteosarcoma.

Citation

Wongrakpanich, A., Bui Thi Thu, H., Sakchaisri, K., Taresco, V., Cuzzucoli Crucitti, V., Bunsupa, S., & Suksiriworapong, J. (2024). Co-delivery of curcumin and resveratrol by folic acid-conjugated poly(glycerol adipate) nanoparticles for enhanced synergistic anticancer effect against osteosarcoma. Journal of Drug Delivery Science and Technology, 95, Article 105610. https://doi.org/10.1016/j.jddst.2024.105610

Journal Article Type Article
Acceptance Date Mar 22, 2024
Online Publication Date Mar 23, 2024
Publication Date 2024-05
Deposit Date Mar 30, 2024
Publicly Available Date Apr 5, 2024
Journal Journal of Drug Delivery Science and Technology
Print ISSN 1773-2247
Electronic ISSN 1773-2247
Publisher Elsevier
Peer Reviewed Peer Reviewed
Volume 95
Article Number 105610
DOI https://doi.org/10.1016/j.jddst.2024.105610
Keywords Curcumin, Resveratrol, Nanoparticle, Osteosarcoma, Co-delivery, Synergistic
Public URL https://nottingham-repository.worktribe.com/output/33027810

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