Enantioselective de novo synthesis of 14-hydroxy-6-oxomorphinans

Moore, Jonathan C.; Modell, Louis; Glenn, Jacqueline R.; Jones, Kieran D.; Argent, Stephen P.; Lane, J. Robert; Canals, Meritxell; Lam, Hon Wai

Abstract

The enantioselective de novo synthesis of pharmacologically important 14-hydroxy-6-oxomorphinans is described. 4,5-Desoxynaltrexone and 4,5-desoxynaloxone were prepared using this route and their biological activities against the opioid receptors were measured.

Citation

Moore, J. C., Modell, L., Glenn, J. R., Jones, K. D., Argent, S. P., Lane, J. R., Canals, M., & Lam, H. W. (2024). Enantioselective de novo synthesis of 14-hydroxy-6-oxomorphinans. Chemical Communications, 60(47), 6007-6010. https://doi.org/10.1039/d4cc01788a

• Journal Article Type: Article
• Acceptance Date: May 10, 2024
• Online Publication Date: May 10, 2024
• Publication Date: Jun 14, 2024
• Deposit Date: May 25, 2024
• Publicly Available Date: May 29, 2024
• Journal: Chemical Communications
• Print ISSN: 1359-7345
• Electronic ISSN: 1364-548X
• Publisher: Royal Society of Chemistry
• Peer Reviewed: Peer Reviewed
• Volume: 60
• Issue: 47
• Pages: 6007-6010
• DOI: https://doi.org/10.1039/d4cc01788a
• Public URL: https://nottingham-repository.worktribe.com/output/35160416
• Publisher URL: https://pubs.rsc.org/en/content/articlelanding/2024/cc/d4cc01788a