Enantioselective de novo synthesis of 14-hydroxy-6-oxomorphinans

Moore, Jonathan C.; Modell, Louis; Glenn, Jacqueline R.; Jones, Kieran D.; Argent, Stephen P.; Lane, J. Robert; Canals, Meritxell; Lam, Hon Wai

doi:10.1039/d4cc01788a

Enantioselective de novo synthesis of 14-hydroxy-6-oxomorphinans

Moore, Jonathan C.; Modell, Louis; Glenn, Jacqueline R.; Jones, Kieran D.; Argent, Stephen P.; Lane, J. Robert; Canals, Meritxell; Lam, Hon Wai

Authors

Jonathan C. Moore

Louis Modell

Jacqueline R. Glenn

Kieran D. Jones

STEPHEN ARGENT stephen.argent@nottingham.ac.uk
Senior Research Fellow

J. Robert Lane

MERITXELL CANALS M.CANALS@NOTTINGHAM.AC.UK
Professor of Cellular Pharmacology

HON LAM Hon.Lam@nottingham.ac.uk
Professor of Sustainable Chemistry

Abstract

The enantioselective de novo synthesis of pharmacologically important 14-hydroxy-6-oxomorphinans is described. 4,5-Desoxynaltrexone and 4,5-desoxynaloxone were prepared using this route and their biological activities against the opioid receptors were measured.

Journal Article Type	Article
Acceptance Date	May 10, 2024
Online Publication Date	May 10, 2024
Deposit Date	May 25, 2024
Publicly Available Date	May 29, 2024
Journal	Chemical Communications
Print ISSN	1359-7345
Electronic ISSN	1364-548X
Publisher	Royal Society of Chemistry
Peer Reviewed	Peer Reviewed
DOI	https://doi.org/10.1039/d4cc01788a
Public URL	https://nottingham-repository.worktribe.com/output/35160416
Publisher URL	https://pubs.rsc.org/en/content/articlelanding/2024/cc/d4cc01788a