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Green tea catechins and their metabolites in human skin before and after exposure to ultraviolet radiation (2015)
Journal Article

Dietary flavonoids may protect against sunburn inflammation in skin. Preliminary reports using less complete analysis suggest that certain catechins and their metabolites are found in skin biopsies and blister fluid after consumption of green tea; ho... Read More about Green tea catechins and their metabolites in human skin before and after exposure to ultraviolet radiation.

The effects of chronic trans-resveratrol supplementation on aspects of cognitive function, mood, sleep, health and cerebral blood flow in healthy, young humans (2015)
Journal Article

Single doses of resveratrol have previously been shown to increase cerebral blood flow (CBF) with no clear effect on cognitive function or mood in healthy adults. Chronic resveratrol consumption may increase the poor bioavailability of resveratrol or... Read More about The effects of chronic trans-resveratrol supplementation on aspects of cognitive function, mood, sleep, health and cerebral blood flow in healthy, young humans.

A randomized controlled trial of green tea catechins in protection against ultraviolet radiation–induced cutaneous inflammation (2015)
Journal Article

Background: Safe systemic protection from the health hazards of ultraviolet radiation (UVR) in sunlight is desirable. Green tea is consumed globally and is reported to have anti-inflammatory properties, which may be mediated through the impact on cyc... Read More about A randomized controlled trial of green tea catechins in protection against ultraviolet radiation–induced cutaneous inflammation.

Gastrointestinal absorption and metabolism of hesperetin-7-O-rutinoside and hesperetin-7-O-glucoside in healthy humans (2015)
Journal Article

Scope Hesperetin?7?O ?rutinoside (hesperidin) reduces blood pressure in healthy volunteers but its intestinal absorption and metabolism are not fully understood. Therefore, we aimed to determine sites of absorption and metabolism of dietary flavanon... Read More about Gastrointestinal absorption and metabolism of hesperetin-7-O-rutinoside and hesperetin-7-O-glucoside in healthy humans.

High performance liquid chromatography tandem mass spectrometry dual extraction method for identification of green tea catechin metabolites excreted in human urine (2014)
Journal Article

The simultaneous analysis of free-form and conjugated flavonoids in the same sample is difficult but necessary to properly estimate their bioavailability. A method was developed to optimise the extraction of both free and conjugated forms of catechin... Read More about High performance liquid chromatography tandem mass spectrometry dual extraction method for identification of green tea catechin metabolites excreted in human urine.

Effects of resveratrol alone or in combination with piperine on cerebral blood flow parameters and cognitive performance in human subjects: a randomised, double-blind, placebo-controlled, cross-over investigation (2014)
Journal Article

Previous research has shown that resveratrol can increase cerebral blood flow (CBF) in the absence of improved cognitive performance in healthy, young human subjects during the performance of cognitively demanding tasks. This lack of cognitive effect... Read More about Effects of resveratrol alone or in combination with piperine on cerebral blood flow parameters and cognitive performance in human subjects: a randomised, double-blind, placebo-controlled, cross-over investigation.

Urinary metabolite profiling identifies novel colonic metabolites and conjugates of phenolics in healthy volunteers (2014)
Journal Article

Scope The colonic metabolism of dietary flavonoids, phenolic acids and their phenolic metabolites is complex and many metabolites and conjugates have not yet been unambiguously identified in humans. Methods and results Urine samples from nine he... Read More about Urinary metabolite profiling identifies novel colonic metabolites and conjugates of phenolics in healthy volunteers.

Controlled flax interventions for the improvement of menopausal symptoms and postmenopausal bone health: a systematic review (2013)
Journal Article

Concerns regarding hormone therapy safety have led to interest in the use of phytoestrogens for a variety of menopause-related health complaints. Recent meta-analyses concerning soy and postmenopausal bone mineral density, flax and serum cholesterol... Read More about Controlled flax interventions for the improvement of menopausal symptoms and postmenopausal bone health: a systematic review.

Urinary excretion of ginkgolide terpene lactones following acute consumption ofGinkgo bilobaextract: Dose-Dependent Urinary Excretion of Ginkgolides (2013)
Journal Article

Urinary biomarkers of plant food supplement (PFS) exposure/intake represent an accurate, objective tool for determining PFS consumption in humans with applications ranging from epidemiology to subject compliance in clinical trials. Ginkgo biloba rema... Read More about Urinary excretion of ginkgolide terpene lactones following acute consumption ofGinkgo bilobaextract: Dose-Dependent Urinary Excretion of Ginkgolides.

Oral green tea catechin metabolites are incorporated into human skin and protect against UV radiation-induced cutaneous inflammation in association with reduced production of pro-inflammatory eicosanoid 12-hydroxyeicosatetraenoic acid (2013)
Journal Article

Green tea catechins (GTC) reduce UV radiation (UVR)-induced inflammation in experimental models, but human studies are scarce and their cutaneous bioavailability and mechanism of photoprotection are unknown. We aimed to examine oral GTC cutaneous upt... Read More about Oral green tea catechin metabolites are incorporated into human skin and protect against UV radiation-induced cutaneous inflammation in association with reduced production of pro-inflammatory eicosanoid 12-hydroxyeicosatetraenoic acid.

Predicting Phenolic Acid Absorption in Caco-2 Cells: A Theoretical Permeability Model and Mechanistic Study (2011)
Journal Article

There is a considerable need to rationalize the membrane permeability and mechanism of transport for potential nutraceuticals. The aim of this investigation was to develop a theoretical permeability equation, based on a reported descriptive absorptio... Read More about Predicting Phenolic Acid Absorption in Caco-2 Cells: A Theoretical Permeability Model and Mechanistic Study.

Review of the efficacy of green tea, isoflavones and aloe vera supplements based on randomised controlled trials (2011)
Journal Article

We assess the evidence for health benefits of three commonly consumed plant food supplements (PFS), green tea, isoflavone and aloe vera, based on published systematic reviews of randomised controlled trials (RCTs). Whilst the potential benefits of gr... Read More about Review of the efficacy of green tea, isoflavones and aloe vera supplements based on randomised controlled trials.

Influence of Combined Biotic and Abiotic Stress on Nutritional Quality Parameters in Tomato (Solanum lycopersicum) (2011)
Journal Article

Induction of abiotic stress in tomato plants has been proposed as a mechanism for improving the nutritional quality of fruits. However, the occurrence of biotic stress can interfere with normal abiotic stress responses. In this study, the combined ef... Read More about Influence of Combined Biotic and Abiotic Stress on Nutritional Quality Parameters in Tomato (Solanum lycopersicum).