All Outputs (71)

Cardiovascular and inflammatory effects of simvastatin therapy in patients with COPD: a randomized controlled trial. (2015)
Journal Article

BACKGROUND: There is excess cardiovascular mortality in patients with chronic obstructive pulmonary disease. Aortic stiffness, an independent predictor of cardiovascular risk, and systemic and airway inflammation are increased in patients with the... Read More about Cardiovascular and inflammatory effects of simvastatin therapy in patients with COPD: a randomized controlled trial..

Exhaled nitric oxide and inhaled corticosteroid dose reduction in asthma: A cohort study (2014)
Journal Article

What characteristics of primary care and patients are associated with early death in patients with lung cancer in the UK? (2014)
Journal Article

Background: The UK has poor lung cancer survival rates and high early mortality, compared to other countries. We aimed to identify factors associated with early death, and features of primary care that might contribute to late diagnosis. Methods: Al... Read More about What characteristics of primary care and patients are associated with early death in patients with lung cancer in the UK?.

Increasing global mortality from idiopathic pulmonary fibrosis in the twenty-first century (2014)
Journal Article

Rationale: Recent evidence from the United Kingdom suggests that the number of deaths from idiopathic pulmonary fibrosis is increasing, although comparable international data are limited. Objectives: We aimed to collate death certification data f... Read More about Increasing global mortality from idiopathic pulmonary fibrosis in the twenty-first century.

Whole Exome Re-Sequencing Implicates CCDC38 and Cilia Structure and Function in Resistance to Smoking Related Airflow Obstruction (2014)
Journal Article

Chronic obstructive pulmonary disease (COPD) is a leading cause of global morbidity and mortality and, whilst smoking remains the single most important risk factor, COPD risk is heritable. Of 26 independent genomic regions showing association with l... Read More about Whole Exome Re-Sequencing Implicates CCDC38 and Cilia Structure and Function in Resistance to Smoking Related Airflow Obstruction.

Respiratory muscle specific warm-up and elite swimming performance (2014)
Journal Article

Background: Inspiratory muscle training has been shown to improve performance in elite swimmers, when used as part of routine training, but its use as a respiratory warm-up has yet to be investigated. Aim: To determine the influence of inspiratory m... Read More about Respiratory muscle specific warm-up and elite swimming performance.

Rate of improvement of CF life expectancy exceeds that of general population: observational death registration study (2014)
Journal Article

Background: It is unclear why cystic fibrosis (CF) survival has improved. We wished to quantify increases in CF median age of death in the context of general population survival improvement. Method: Death registration data analysis (US, England & Wa... Read More about Rate of improvement of CF life expectancy exceeds that of general population: observational death registration study.

Copy Number Variation of the Beta-Defensin Genes in Europeans: No Supporting Evidence for Association with Lung Function, Chronic Obstructive Pulmonary Disease or Asthma (2014)
Journal Article

Lung function measures are heritable, predict mortality and are relevant in diagnosis of chronic obstructive pulmonary disease (COPD). COPD and asthma are diseases of the airways with major public health impacts and each have a heritable component. G... Read More about Copy Number Variation of the Beta-Defensin Genes in Europeans: No Supporting Evidence for Association with Lung Function, Chronic Obstructive Pulmonary Disease or Asthma.

The UK prevalence of hereditary haemorrhagic telangiectasia and its association with sex, socioeconomic status and region of residence: a population-based study (2013)
Journal Article

Background Hereditary haemorrhagic telangiectasia (HHT) is an autosomal dominant genetic disorder of aberrant blood vessel development characterised by arteriovenous malformations. HHT is associated with significant morbidity due to complications inc... Read More about The UK prevalence of hereditary haemorrhagic telangiectasia and its association with sex, socioeconomic status and region of residence: a population-based study.

Presence of a prothrombotic state in people with idiopathic pulmonary fibrosis: a population-based case–control study (2013)
Journal Article

BACKGROUND: Laboratory studies suggest that the clotting cascade is activated in fibrotic lungs. Since humans vary in their tendency to clot due to a variety of inherited or acquired defects, we investigated whether a prothrombotic state increases th... Read More about Presence of a prothrombotic state in people with idiopathic pulmonary fibrosis: a population-based case–control study.

The acute impact of a hematopoietic allograft on lung function and inflammation: a prospective observational study (2013)
Journal Article

Background: No studies have investigated the immediate impact of receiving an allogeneic hematopoietic stem cell transplant (HSCT) on pulmonary inflammation or lung function. Methods: Using a prospective study design, we quantified the changes in... Read More about The acute impact of a hematopoietic allograft on lung function and inflammation: a prospective observational study.