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Presence of a prothrombotic state in people with idiopathic pulmonary fibrosis: a population-based case-control study

Navaratnam, Vidya; Fogarty, Andrew W.; McKeever, Tricia M.; Thompson, Norma; Jenkins, Gisli; Johnson, Simon R.; Dolan, Gerard; Kumaran, Maruti; Pointon, Kate; Hubbard, Richard B.

Authors

Vidya Navaratnam vidya.navaratnam@nottingham.ac.uk

Andrew W. Fogarty andrew.fogarty@nottingham.ac.uk

Tricia M. McKeever tricia.mckeever@nottingham.ac.uk

Norma Thompson

Gisli Jenkins

Simon R. Johnson Simon.Johnson@nottingham.ac.uk

Gerard Dolan

Maruti Kumaran

Kate Pointon

Richard B. Hubbard richard.hubbard@nottingham.ac.uk



Abstract

BACKGROUND: Laboratory studies suggest that the clotting cascade is activated in fibrotic lungs. Since humans vary in their tendency to clot due to a variety of inherited or acquired defects, we investigated whether a prothrombotic state increases the chance of developing idiopathic pulmonary fibrosis (IPF) and/or worsens the prognosis of IPF.

METHODS: We recruited 211 incident cases of IPF and 256 age-and sex-matched general population controls and collected data on medical history, medication, smoking habit, blood samples as well as lung function and high-resolution CT scans done as part of routine clinical care. A prothrombotic state was defined as the presence of at least one inherited or acquired clotting defect or marker of fibrinolytic dysfunction. We used logistic regression to quantify the association between a prothrombotic state and IPF adjusted for age, sex, smoking habit and highly sensitive C reactive protein. Cox regression was used to determine the influence of a prothrombotic state on survival.

RESULTS: Cases were more than four times more likely than controls to have a prothrombotic state (OR 4.78, 95% CI 2.93 to 7.80; p

Journal Article Type Article
Publication Date Mar 1, 2014
Journal Thorax
Print ISSN 0040-6376
Electronic ISSN 1468-3296
Publisher BMJ Publishing Group
Peer Reviewed Peer Reviewed
Volume 69
Issue 3
APA6 Citation Navaratnam, V., Fogarty, A. W., McKeever, T. M., Thompson, N., Jenkins, G., Johnson, S. R., …Hubbard, R. B. (2014). Presence of a prothrombotic state in people with idiopathic pulmonary fibrosis: a population-based case-control study. Thorax, 69(3), doi:10.1136/thoraxjnl-2013-203740
DOI https://doi.org/10.1136/thoraxjnl-2013-203740
Publisher URL http://thorax.bmj.com/content/69/3/207
Copyright Statement Copyright information regarding this work can be found at the following address: http://eprints.nottingh.../end_user_agreement.pdf

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Copyright Statement
Copyright information regarding this work can be found at the following address: http://eprints.nottingham.ac.uk/end_user_agreement.pdf





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