All Outputs (80)

Starch/Poly(glycerol-adipate) Nanocomposites: A Novel Oral Drug Delivery Device (2020)
Journal Article
Vestri, A., Pearce, A. K., Cavanagh, R., Styliari, I. D., Sanders, C., Couturaud, B., Schenone, S., Taresco, V., Jakobsen, R. R., Howdle, S. M., Musumeci, F., & Sagnelli, D. (2020). Starch/Poly(glycerol-adipate) Nanocomposites: A Novel Oral Drug Delivery Device. Coatings, 10(2), Article 125. https://doi.org/10.3390/coatings10020125

Biocompatible and bio-based materials are an appealing resource for the pharmaceutical industry. Poly(glycerol-adipate) (PGA) is a biocompatible and biodegradable polymer that can be used to produce self-assembled nanoparticles (NPs) able to encapsul... Read More about Starch/Poly(glycerol-adipate) Nanocomposites: A Novel Oral Drug Delivery Device.

Enzymatic One-Pot Synthesis of Renewable and Biodegradable Surfactants in Supercritical Carbon Dioxide (scCO2) (2020)
Journal Article
d’Almeida Gamiero, M., Goddard, A. . R., Taresco, V., & Howdle, S. M. (2020). Enzymatic One-Pot Synthesis of Renewable and Biodegradable Surfactants in Supercritical Carbon Dioxide (scCO2). Green Chemistry, 22(4), 1308-1318. https://doi.org/10.1039/c9gc04011k

We seek to expand the opportunities to exploit glycerol, a largely untapped renewable feedstock, by exploiting enzymatic catalysis in supercritical carbon dioxide (scCO2). This work highlights a promising and clean approach to bio-renewable amphiphil... Read More about Enzymatic One-Pot Synthesis of Renewable and Biodegradable Surfactants in Supercritical Carbon Dioxide (scCO2).

A ‘greener’ one-pot synthesis of monoterpene-functionalised lactide oligomers (2020)
Journal Article
O'Brien, D. M., Atkinson, R. L., Cavanagh, R., Pacheco, A. A., Larder, R., Kortsen, K., Krumins, E., Haddleton, A. J., Alexander, C., Stockman, R. A., Howdle, S. M., & Taresco, V. (2020). A ‘greener’ one-pot synthesis of monoterpene-functionalised lactide oligomers. European Polymer Journal, 125, 109516. https://doi.org/10.1016/j.eurpolymj.2020.109516

© 2020 Elsevier Ltd In this work we aimed to achieve a totally sustainable Ring Opening Polymerisation (ROP) process, by harmonising the use of naturally occurring or derivable initiators and the green solvent 2-Methyltetrahydrofuran (2-MeTHF). First... Read More about A ‘greener’ one-pot synthesis of monoterpene-functionalised lactide oligomers.

Highly coloured and electrophoretically active polymer microparticles via staggered dispersion polymerisation in supercritical carbon dioxide and dodecane (2019)
Journal Article
McAllister, T. D., Bennett, T. M., Petrillo, C., Topping, C., Farrand, L. D., Smith, N., & Howdle, S. M. (2019). Highly coloured and electrophoretically active polymer microparticles via staggered dispersion polymerisation in supercritical carbon dioxide and dodecane. Journal of Materials Chemistry C, 7(39), 12194-12203. https://doi.org/10.1039/c9tc03558c

Devices featuring electrophoretic displays (EPD) have become extremely popular in recent years because of their low power consumption, high readability and thin display designs, but a product with a full colour gamut comparable with liquid crystal di... Read More about Highly coloured and electrophoretically active polymer microparticles via staggered dispersion polymerisation in supercritical carbon dioxide and dodecane.

Starch/Poly (Glycerol-Adipate) Nanocomposite Film as Novel Biocompatible Materials (2019)
Journal Article
Sagnelli, Cavanagh, Xu, Swainson, Blennow, Duncan, Taresco, & Howdle. (2019). Starch/Poly (Glycerol-Adipate) Nanocomposite Film as Novel Biocompatible Materials. Coatings, 9(8), Article 482. https://doi.org/10.3390/coatings9080482

Starch is one of the most abundant polysaccharides on the earth and it is the most important source of energy intake for humans. Thermoplastic starch (TPS) is also widely used for new bio-based materials. The blending of starch with other molecules m... Read More about Starch/Poly (Glycerol-Adipate) Nanocomposite Film as Novel Biocompatible Materials.

Epoxy–amine oligomers from terpenes with applications in synergistic antifungal treatments (2019)
Journal Article
O’Brien, D. M., Vallieres, C., Alexander, C., Howdle, S. M., Stockman, R. A., & Avery, S. V. (2019). Epoxy–amine oligomers from terpenes with applications in synergistic antifungal treatments. Journal of Materials Chemistry B, 7(34), 5222-5229. https://doi.org/10.1039/c9tb00878k

A bis-epoxide monomer was synthesised in two steps from (R)-carvone, a terpenoid renewable feedstock derived from spearmint oil, and used to prepare β-aminoalcohol oligomers in polyaddition reactions with bis-amines without requiring solvent or catal... Read More about Epoxy–amine oligomers from terpenes with applications in synergistic antifungal treatments.

In situ Crosslinking of Nanostructured Block Copolymer Microparticles in Supercritical Carbon Dioxide (2019)
Journal Article
He, G., Bennett, T. M., Alias, K., Jiang, L., Schwab, S., Alauhdin, M., & Howdle, S. M. (2019). In situ Crosslinking of Nanostructured Block Copolymer Microparticles in Supercritical Carbon Dioxide. Polymer Chemistry, 10(29), 3960-3972. https://doi.org/10.1039/c9py00556k

We report a novel and facile approach to “fix” the internal nanostructure of block copolymer (BCP) microparticles via in situ crosslinking copolymerisation in dispersion in supercritical CO2 (scCO2). By delaying the addition of the crosslinker and a... Read More about In situ Crosslinking of Nanostructured Block Copolymer Microparticles in Supercritical Carbon Dioxide.

Polyacrylates Derived from Biobased Ethyl Lactate Solvent via SET-LRP (2019)
Journal Article
Bensabeh, N., Moreno, A., Roig, A., Monaghan, O. R., Ronda, J. C., Cádiz, V., Galià, M., Howdle, S. M., Lligadas, G., & Percec, V. (2019). Polyacrylates Derived from Biobased Ethyl Lactate Solvent via SET-LRP. Biomacromolecules, 20(5), 2135-2147. https://doi.org/10.1021/acs.biomac.9b00435

The precise synthesis of polymers derived from alkyl lactate ester acrylates is reported for the first time. Kinetic experiments were conducted to demonstrate that Cu(0) wire-catalyzed single electron transfer-living radical polymerization (SET-LRP)... Read More about Polyacrylates Derived from Biobased Ethyl Lactate Solvent via SET-LRP.

Monitoring morphology evolution within block copolymer microparticles during dispersion polymerisation in supercritical carbon dioxide: a high pressure SAXS study (2019)
Journal Article
Alauhdin, M., Bennett, T. M., He, G., Bassett, S. P., Portale, G., Bras, W., Hermida-Merino, D., & Howdle, S. M. (2019). Monitoring morphology evolution within block copolymer microparticles during dispersion polymerisation in supercritical carbon dioxide: a high pressure SAXS study. Polymer Chemistry, 10(7), 860-871. https://doi.org/10.1039/c8py01578c

Reversible addition–fragmentation chain transfer (RAFT) dispersion polymerisation in supercritical carbon dioxide is an effective process for creating block copolymer microparticles with internal nanostructures. Here we report an alternative synthesi... Read More about Monitoring morphology evolution within block copolymer microparticles during dispersion polymerisation in supercritical carbon dioxide: a high pressure SAXS study.

New renewably-sourced polyesters from limonene-derived monomers (2018)
Journal Article
Thomsett, M. R., Moore, J. C., Buchard, A., Stockman, R. A., & Howdle, S. M. (2019). New renewably-sourced polyesters from limonene-derived monomers. Green Chemistry, 21(1), 149-156. https://doi.org/10.1039/c8gc02957a

The functionalisation of limonene has enabled the synthesis of two renewably-sourced monomers for the formation of terpene-derived polyesters. Three methods for the synthesis of the novel hydroxy-acid 6 are reported and their green-credentials scruti... Read More about New renewably-sourced polyesters from limonene-derived monomers.

Clean Block Copolymer Microparticles from Supercritical CO 2 : Universal Templates for the Facile and Scalable Fabrication of Hierarchical Mesostructured Metal Oxides (2018)
Journal Article
Bennett, T. M., He, G., Larder, R. R., Fischer, M. G., Rance, G. A., Fay, M. W., Pearce, A. K., Parmenter, C. D. J., Steiner, U., & Howdle, S. M. (2018). Clean Block Copolymer Microparticles from Supercritical CO 2 : Universal Templates for the Facile and Scalable Fabrication of Hierarchical Mesostructured Metal Oxides. Nano Letters, 18(12), 7560-7569. https://doi.org/10.1021/acs.nanolett.8b03044

© 2018 American Chemical Society. Metal oxide microparticles with well-defined internal mesostructures are promising materials for a variety of different applications, but practical routes to such materials that allow the constituent structural leng... Read More about Clean Block Copolymer Microparticles from Supercritical CO 2 : Universal Templates for the Facile and Scalable Fabrication of Hierarchical Mesostructured Metal Oxides.

Sustainable synthesis and precise characterisation of bio-based star polycaprolactone synthesised with a metal catalyst and with lipase (2018)
Journal Article
Baheti, P., Gimello, O., Bouilhac, C., Lacroix-Desmazes, P., & Howdle, S. M. (2018). Sustainable synthesis and precise characterisation of bio-based star polycaprolactone synthesised with a metal catalyst and with lipase. Polymer Chemistry, 9(47), 5594-5607. https://doi.org/10.1039/c8py01266k

Bio-based building blocks and sustainable synthesis pathways were used to synthesise star-shaped polymers composed of a D-sorbitol core and polycaprolactone arms by ring opening polymerisation (ROP). The use of volatile organic solvents was avoided a... Read More about Sustainable synthesis and precise characterisation of bio-based star polycaprolactone synthesised with a metal catalyst and with lipase.

Antimicrobial peptide encapsulation and sustained release from polymer network particles prepared in supercritical carbon dioxide (2018)
Journal Article
Parilti, R., Caprasse, J., Riva, R., Alexandre, M., Vandegaart, H., Bebrone, C., Dupont-Gillain, C., Howdle, S. M., & Jérôme, C. (2018). Antimicrobial peptide encapsulation and sustained release from polymer network particles prepared in supercritical carbon dioxide. Journal of Colloid and Interface Science, 532, 112-117. https://doi.org/10.1016/j.jcis.2018.07.125

© 2018 Antimicrobial peptide loaded poly(2-hydroxyethyl methacrylate) particles were synthesized in supercritical carbon dioxide via one-pot free-radical dispersion polymerisation of 2-hydroxyethyl methacrylate and a cross-linker. Discrete particles... Read More about Antimicrobial peptide encapsulation and sustained release from polymer network particles prepared in supercritical carbon dioxide.

Sulindac encapsulation and release from functional poly(HEMA) microparticles prepared in supercritical carbon dioxide (2018)
Journal Article
Parilti, R., Riva, R., Howdle, S. M., Dupont-Gillain, C., & Jerome, C. (2018). Sulindac encapsulation and release from functional poly(HEMA) microparticles prepared in supercritical carbon dioxide. International Journal of Pharmaceutics, 549(1-2), 161-168. https://doi.org/10.1016/j.ijpharm.2018.07.060

Sulindac loaded poly(HEMA) cross-linked microparticles were synthesized via one-pot free radical dispersion polymerisation in supercritical carbon dioxide (scCO2) in presence of photocleavable diblock stabilisers based on polyethylene oxide (PEO) and... Read More about Sulindac encapsulation and release from functional poly(HEMA) microparticles prepared in supercritical carbon dioxide.

A facile route to bespoke macro- and mesoporous block copolymer microparticles (2018)
Journal Article
He, G., Bennett, T. M., Alauhdin, M., Fay, M. W., Liu, X., Schwab, S. T., Sun, C.-G., & Howdle, S. M. (in press). A facile route to bespoke macro- and mesoporous block copolymer microparticles. Polymer Chemistry, 9(27), https://doi.org/10.1039/c8py00707a

We report a facile and versatile strategy for the bespoke fabrication of macro- and mesoporous block copolymer microparticles. A clean synthetic route, RAFT dispersion polymerisation in supercritical carbon dioxide (scCO2), is used to generate block... Read More about A facile route to bespoke macro- and mesoporous block copolymer microparticles.

Biocompatible unimolecular micelles obtained via the Passerini reaction as versatile nanocarriers for potential medical applications (2018)
Journal Article
Oelmann, S., Travanut, A., Barther, D., Romero, M., Howdle, S. M., Alexander, C., & Meier, M. A. (2019). Biocompatible unimolecular micelles obtained via the Passerini reaction as versatile nanocarriers for potential medical applications. Biomacromolecules, 20(1), 90-101. https://doi.org/10.1021/acs.biomac.8b00592

A Passerini three-component polymerization was performed for the synthesis of amphiphilic star-shaped block copolymers with hydrophobic cores and hydrophilic coronae. The degree of polymerization of the hydrophobic core was varied from 5 to 10 repeat... Read More about Biocompatible unimolecular micelles obtained via the Passerini reaction as versatile nanocarriers for potential medical applications.

Synthesis and control of crosslinked poly(acrylic acid) based viscosity modifiers using dense phase carbon dioxide as a solvent (2018)
Journal Article
Alexander, W., Wickson, J., Duncan, J., Carmichael, K., Irvine, D., & Howdle, S. (2018). Synthesis and control of crosslinked poly(acrylic acid) based viscosity modifiers using dense phase carbon dioxide as a solvent. Journal of Supercritical Fluids, 139, 38-44. https://doi.org/10.1016/j.supflu.2018.05.003

We investigate the clean synthesis of a cross-linked poly(acrylic acid) viscosity modifier using supercritical CO2 to replace more hazardous volatile organic solvents that are typically used for this process. The polymers were analysed by aqueous swe... Read More about Synthesis and control of crosslinked poly(acrylic acid) based viscosity modifiers using dense phase carbon dioxide as a solvent.

Can a combination of poly(ethylene glycol) and dense phase carbon dioxide improve processing of polylactide? A high pressure rheology investigation (2017)
Journal Article
Pepper, K., Masson, T., De Focatiis, D. S., & Howdle, S. M. (in press). Can a combination of poly(ethylene glycol) and dense phase carbon dioxide improve processing of polylactide? A high pressure rheology investigation. Journal of Supercritical Fluids, 133(1), https://doi.org/10.1016/j.supflu.2017.10.014

High temperature melts or use of organic solvents are not practicable approaches for encapsulating protein based or thermally labile drugs into degradable polymers. Here, we demonstrate that poly(ethylene glycol) (PEG) in combination with supercritic... Read More about Can a combination of poly(ethylene glycol) and dense phase carbon dioxide improve processing of polylactide? A high pressure rheology investigation.

Versatile routes to functional RAFT chain transfer agents through the Passerini multicomponent reaction (2017)
Journal Article
Pearce, A. K., Travanut, A., Couturaud, B., Taresco, V., Howdle, S. M., Alexander, M. R., & Alexander, C. (2017). Versatile routes to functional RAFT chain transfer agents through the Passerini multicomponent reaction. ACS Macro Letters, 6(7), 781-785. https://doi.org/10.1021/acsmacrolett.7b00415

The widespread adoption of RAFT polymerization stems partly from the ease and utility of installing a functional chain transfer agent onto the ends of the generated polymer chains. In parallel, the Passerini multicomponent reaction offers great versa... Read More about Versatile routes to functional RAFT chain transfer agents through the Passerini multicomponent reaction.

One-pot synthesis of micron-sized polybetaine particles: innovative use of supercritical carbon dioxide (2017)
Journal Article
Bassett, S. P., Birkin, N. A., Jennings, J., Champman, E., O'Reilly, R. K., Howdle, S. M., & Willcock, H. (in press). One-pot synthesis of micron-sized polybetaine particles: innovative use of supercritical carbon dioxide. Polymer Chemistry, 8, https://doi.org/10.1039/C7PY00455A

Polybetaines exhibit unique properties combining anti-polyelectrolyte and low protein fouling behaviour, as well as biocompatibility. To date, the synthesis of polybetaine particles >50 nm has proved to be extremely challenging with standard emulsion... Read More about One-pot synthesis of micron-sized polybetaine particles: innovative use of supercritical carbon dioxide.