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Can a combination of poly(ethylene glycol) and dense phase carbon dioxide improve processing of polylactide? A high pressure rheology investigation

Pepper, Katie; Masson, Timothé; De Focatiis, Davide S.A.; Howdle, Steven M.

Authors

Katie Pepper

Timothé Masson

Davide S.A. De Focatiis

Steven M. Howdle



Abstract

High temperature melts or use of organic solvents are not practicable approaches for encapsulating protein based or thermally labile drugs into degradable polymers. Here, we demonstrate that poly(ethylene glycol) (PEG) in combination with supercritical carbon dioxide (scCO2) can dramatically reduce the viscosity of polymer melts allowing enhanced uptake of CO2 into poly(D,L-lactide) (PLA). Both PEG and CO2 are approved excipients in drug delivery and it is well documented that individually both are effective plasticisers. Using high pressure rheology techniques (scCO₂ at 14 MPa) we demonstrate a synergistic impact leading to significantly lower processing temperatures with PEG employed as both a blended additive and as a component of a block copolymer.

Journal Article Type Article
Journal Journal of Supercritical Fluids
Print ISSN 0896-8446
Electronic ISSN 1872-8162
Publisher Elsevier
Peer Reviewed Peer Reviewed
Volume 133
Issue 1
APA6 Citation Pepper, K., Masson, T., De Focatiis, D. S., & Howdle, S. M. (in press). Can a combination of poly(ethylene glycol) and dense phase carbon dioxide improve processing of polylactide? A high pressure rheology investigation. Journal of Supercritical Fluids, 133(1), doi:10.1016/j.supflu.2017.10.014
DOI https://doi.org/10.1016/j.supflu.2017.10.014
Keywords Viscosity, Rheology, Polymers, PLA, PEG, Block copolymers,
Blends, Supercritical carbon dioxide
Publisher URL http://www.sciencedirect.com/science/article/pii/S0896844617304631
Copyright Statement Copyright information regarding this work can be found at the following address: http://creativecommons.org/licenses/by-nc-nd/4.0

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Copyright Statement
Copyright information regarding this work can be found at the following address: http://creativecommons.org/licenses/by-nc-nd/4.0





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