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Antimicrobial peptide encapsulation and sustained release from polymer network particles prepared in supercritical carbon dioxide

Parilti, Rahmet; Caprasse, Jérémie; Riva, Raphaël; Alexandre, Michaël; Vandegaart, Hélène; Bebrone, Carine; Dupont-Gillain, Christine; Howdle, Steven M.; Jérôme, Christine

Authors

Rahmet Parilti

Jérémie Caprasse

Raphaël Riva

Michaël Alexandre

Hélène Vandegaart

Carine Bebrone

Christine Dupont-Gillain

Christine Jérôme



Abstract

Antimicrobial peptide loaded poly(2-hydroxyethyl methacrylate) particles were synthesized in supercritical carbon dioxide via one-pot free-radical dispersion polymerisation of 2-hydroxyethyl methacrylate and a cross-linker. Discrete particles with a well-defined spherical morphology and a diameter as low as 450 nm have been obtained in mild conditions. The encapsulation and release of the peptide were confirmed by antimicrobial tests that demonstrated for the first time a sustained release of the peptide from poly(2-hydroxyethyl methacrylate) microgels prepared by one-pot dispersion polymerization in supercritical carbon dioxide and then dispersed in water.
Keywords: Encapsulation; microgel; antimicrobial peptide; supercritical carbon dioxide; polymers.

Journal Article Type Article
Publication Date Dec 15, 2018
Journal Journal of Colloid and Interface Science
Print ISSN 0021-9797
Publisher Elsevier
Peer Reviewed Peer Reviewed
Volume 532
Pages 112-117
APA6 Citation Parilti, R., Caprasse, J., Riva, R., Alexandre, M., Vandegaart, H., Bebrone, C., …Jérôme, C. (2018). Antimicrobial peptide encapsulation and sustained release from polymer network particles prepared in supercritical carbon dioxide. Journal of Colloid and Interface Science, 532, 112-117. doi:10.1016/j.jcis.2018.07.125
DOI https://doi.org/10.1016/j.jcis.2018.07.125
Keywords Colloid and Surface Chemistry; Electronic, Optical and Magnetic Materials; Surfaces, Coatings and Films; Biomaterials
Publisher URL https://www.sciencedirect.com/science/article/pii/S0021979718308907?via%3Dihub

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