Skip to main content

Research Repository

Advanced Search

Antimicrobial peptide encapsulation and sustained release from polymer network particles prepared in supercritical carbon dioxide

Parilti, Rahmet; Caprasse, Jérémie; Riva, Raphaël; Alexandre, Michaël; Vandegaart, Hélène; Bebrone, Carine; Dupont-Gillain, Christine; Howdle, Steven M.; Jérôme, Christine

Antimicrobial peptide encapsulation and sustained release from polymer network particles prepared in supercritical carbon dioxide Thumbnail


Authors

Rahmet Parilti

Jérémie Caprasse

Raphaël Riva

Michaël Alexandre

Hélène Vandegaart

Carine Bebrone

Christine Dupont-Gillain

Christine Jérôme



Abstract

© 2018 Antimicrobial peptide loaded poly(2-hydroxyethyl methacrylate) particles were synthesized in supercritical carbon dioxide via one-pot free-radical dispersion polymerisation of 2-hydroxyethyl methacrylate and a cross-linker. Discrete particles with a well-defined spherical morphology and a diameter as low as 450 nm have been obtained in mild conditions. The encapsulation and release of the peptide were confirmed by antimicrobial tests that demonstrated for the first time a sustained release of the peptide from poly(2-hydroxyethyl methacrylate) microgels prepared by one-pot dispersion polymerization in supercritical carbon dioxide and then dispersed in water.

Journal Article Type Article
Acceptance Date Jul 28, 2018
Online Publication Date Jul 29, 2018
Publication Date Dec 15, 2018
Deposit Date Mar 8, 2019
Publicly Available Date Jul 30, 2019
Journal Journal of Colloid and Interface Science
Print ISSN 0021-9797
Electronic ISSN 1095-7103
Publisher Elsevier
Peer Reviewed Peer Reviewed
Volume 532
Pages 112-117
DOI https://doi.org/10.1016/j.jcis.2018.07.125
Keywords Colloid and Surface Chemistry; Electronic, Optical and Magnetic Materials; Surfaces, Coatings and Films; Biomaterials
Public URL https://nottingham-repository.worktribe.com/output/1619621
Publisher URL https://www.sciencedirect.com/science/article/pii/S0021979718308907?via%3Dihub

Files




You might also like



Downloadable Citations