Skip to main content

Research Repository

Advanced Search

Sulindac encapsulation and release from functional poly(HEMA) microparticles prepared in supercritical carbon dioxide

Parilti, Rahmet; Riva, Raphaël; Howdle, Steven M.; Dupont-Gillain, Christine; Jerome, Christine

Authors

Rahmet Parilti

Raphaël Riva

Christine Dupont-Gillain

Christine Jerome



Abstract

Sulindac loaded poly(HEMA) cross-linked microparticles were synthesized via one-pot free radical dispersion polymerisation in supercritical carbon dioxide (scCO2) in presence of photocleavable diblock stabilisers based on polyethylene oxide (PEO) and poly(heptadecafluorodecyl acrylate) (PFDA) bearing a o-nitrobenzyl photosensitive junction (hv) (PEO-hv-PFDA), and ethylene glycol dimethacrylate (EGDMA) as cross-linker. Poly(HEMA) cross-linked microparticles either empty or sulindac loaded were obtained with well-defined spherical morphology with the sizes between 250-350 nm. Additionally, upon UV-photolysis the stabiliser on the surface was cleaved which permits to microparticles to be redispersed in water leading to water swollen microgels about 2.1-3.6 µm. Moreover, the release behaviour from obtained microgels indicated the sustained release of sulindac over 10 days. Besides, the surface modification after UV-photolysis was studied and proved that the particles can be functionalised with further chemistries.

Journal Article Type Article
Publication Date Oct 5, 2018
Journal International Journal of Pharmaceutics
Print ISSN 0378-5173
Publisher Elsevier
Peer Reviewed Peer Reviewed
Volume 549
Issue 1-2
Pages 161-168
APA6 Citation Parilti, R., Riva, R., Howdle, S. M., Dupont-Gillain, C., & Jerome, C. (2018). Sulindac encapsulation and release from functional poly(HEMA) microparticles prepared in supercritical carbon dioxide. International Journal of Pharmaceutics, 549(1-2), 161-168. doi:10.1016/j.ijpharm.2018.07.060
DOI https://doi.org/10.1016/j.ijpharm.2018.07.060
Keywords Pharmaceutical Science

Files



You might also like



Downloadable Citations

;