Sulindac encapsulation and release from functional poly(HEMA) microparticles prepared in supercritical carbon dioxide

Parilti, Rahmet; Riva, Raphaël; Howdle, Steven M.; Dupont-Gillain, Christine; Jerome, Christine

Abstract

Sulindac loaded poly(HEMA) cross-linked microparticles were synthesized via one-pot free radical dispersion polymerisation in supercritical carbon dioxide (scCO2) in presence of photocleavable diblock stabilisers based on polyethylene oxide (PEO) and poly(heptadecafluorodecyl acrylate) (PFDA) bearing a o-nitrobenzyl photosensitive junction (hv) (PEO-hv-PFDA), and ethylene glycol dimethacrylate (EGDMA) as cross-linker. Poly(HEMA) cross-linked microparticles either empty or sulindac loaded were obtained with well-defined spherical morphology with the sizes between 250-350 nm. Additionally, upon UV-photolysis the stabiliser on the surface was cleaved which permits to microparticles to be redispersed in water leading to water swollen microgels about 2.1-3.6 µm. Moreover, the release behaviour from obtained microgels indicated the sustained release of sulindac over 10 days. Besides, the surface modification after UV-photolysis was studied and proved that the particles can be functionalised with further chemistries.

Citation

Parilti, R., Riva, R., Howdle, S. M., Dupont-Gillain, C., & Jerome, C. (2018). Sulindac encapsulation and release from functional poly(HEMA) microparticles prepared in supercritical carbon dioxide. International Journal of Pharmaceutics, 549(1-2), 161-168. https://doi.org/10.1016/j.ijpharm.2018.07.060

• Journal Article Type: Article
• Acceptance Date: Jul 25, 2018
• Online Publication Date: Jul 26, 2018
• Publication Date: Oct 5, 2018
• Deposit Date: Mar 8, 2019
• Publicly Available Date: Jul 27, 2019
• Journal: International Journal of Pharmaceutics
• Print ISSN: 0378-5173
• Electronic ISSN: 1873-3476
• Publisher: Elsevier
• Peer Reviewed: Peer Reviewed
• Volume: 549
• Issue: 1-2
• Pages: 161-168
• DOI: https://doi.org/10.1016/j.ijpharm.2018.07.060
• Keywords: Pharmaceutical Science
• Public URL: https://nottingham-repository.worktribe.com/output/1619723
• Publisher URL: https://www.sciencedirect.com/science/article/abs/pii/S0378517318305350?via%3Dihub