Stefan Oelmann
Biocompatible unimolecular micelles obtained via the Passerini reaction as versatile nanocarriers for potential medical applications
Oelmann, Stefan; Travanut, Alessandra; Barther, Dennis; Romero, Manuel; Howdle, Steven M.; Alexander, Cameron; Meier, Michael A.R.
Authors
Alessandra Travanut
Dennis Barther
Manuel Romero
Prof. STEVE HOWDLE STEVE.HOWDLE@NOTTINGHAM.AC.UK
Professor of Chemistry
Professor CAMERON ALEXANDER CAMERON.ALEXANDER@NOTTINGHAM.AC.UK
Professor of Polymer Therapeutics
Michael A.R. Meier
Abstract
A Passerini three-component polymerization was performed for the synthesis of amphiphilic star-shaped block copolymers with hydrophobic cores and hydrophilic coronae. The degree of polymerization of the hydrophobic core was varied from 5 to 10 repeating units, and the side chain ends were conjugated by performing a Passerini-3CR with PEG-isocyanide and PEG-aldehyde (950 g/mol). The resulting amphiphilic star-shaped block copolymers contained thioether groups, which could be oxidized to sulfones in order to further tune the polarity of the polymer chains. The ability of the amphiphilic copolymers to act as unimolecular micellar encapsulants was tested with the water-insoluble dye Orange II, the water-soluble dye Para Red and the macrolide antibiotic azithromycin. The results showed that the new copolymers were able to retain drug cargo at pH levels corresponding to circulating blood and selectively release therapeutically effective doses of antibiotic as measured by bacterial cell kill. The polymers were also well-tolerated by differentiated THP-1 macrophages in the absence of encapsulated drugs.
Citation
Oelmann, S., Travanut, A., Barther, D., Romero, M., Howdle, S. M., Alexander, C., & Meier, M. A. (2019). Biocompatible unimolecular micelles obtained via the Passerini reaction as versatile nanocarriers for potential medical applications. Biomacromolecules, 20(1), 90-101. https://doi.org/10.1021/acs.biomac.8b00592
Journal Article Type | Article |
---|---|
Acceptance Date | Jun 5, 2018 |
Online Publication Date | Jun 5, 2018 |
Publication Date | Jan 14, 2019 |
Deposit Date | Jul 26, 2018 |
Publicly Available Date | Jul 26, 2018 |
Journal | Biomacromolecules |
Print ISSN | 1525-7797 |
Electronic ISSN | 1526-4602 |
Publisher | American Chemical Society |
Peer Reviewed | Peer Reviewed |
Volume | 20 |
Issue | 1 |
Pages | 90-101 |
DOI | https://doi.org/10.1021/acs.biomac.8b00592 |
Public URL | https://nottingham-repository.worktribe.com/output/936347 |
Publisher URL | http://dx.doi.org/10.1021/acs.biomac.8b00592 |
Files
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Copyright Statement
Copyright information regarding this work can be found at the following address: http://eprints.nottingham.ac.uk/end_user_agreement.pdf
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