All Outputs (90)
Distinct abnormalities of small bowel and regional colonic volumes in subtypes of irritable bowel syndrome revealed by MRI (2016)
Journal Article
OBJECTIVES: Non-invasive biomarkers which identify different mechanisms of disease in subgroups of irritable bowel syndrome (IBS) could be valuable. Our aim was to seek useful magnetic resonance imaging (MRI) parameters that could distinguish each IB... Read More about Distinct abnormalities of small bowel and regional colonic volumes in subtypes of irritable bowel syndrome revealed by MRI.
Exploring gastrointestinal variables affecting drug and formulation behavior: methodologies, challenges and opportunities (2016)
Journal Article
Various gastrointestinal (GI) factors affect drug and formulation behavior after oral administration, including GI transfer, motility, pH and GI fluid volume and composition. An in-depth understanding of these physiological and anatomical variables i... Read More about Exploring gastrointestinal variables affecting drug and formulation behavior: methodologies, challenges and opportunities.
Colon Hypersensitivity to Distension, Rather Than Excessive Gas Production, Produces Carbohydrate-Related Symptoms in Individuals With Irritable Bowel Syndrome (2016)
Journal Article
Background & Aims: Poorly digested, fermentable carbohydrates may induce symptoms of irritable bowel syndrome (IBS), via unclear mechanisms. We performed a randomized trial with magnetic resonance imaging (MRI) analysis to investigate correlations be... Read More about Colon Hypersensitivity to Distension, Rather Than Excessive Gas Production, Produces Carbohydrate-Related Symptoms in Individuals With Irritable Bowel Syndrome.
IBS and IBD - separate entities or on a spectrum? (2016)
Journal Article
Prior Consumption of a Fat Meal in Healthy Adults Modulates the Brain's Response to Fat (2016)
Journal Article
Background: Consumption of fat is regulated by reward and homeostatic pathways, but no studies have examined the role of the intake of a high fat meal (HFM) on subsequent brain activation to oral stimuli. Objective: We evaluated how prior consumptio... Read More about Prior Consumption of a Fat Meal in Healthy Adults Modulates the Brain's Response to Fat.
Coinfection and Emergence of Rifamycin Resistance during a Recurrent Clostridium difficile Infection (2016)
Journal Article
Clostridium difficile (Peptoclostridium difficile) is a common health care-associated infection with a disproportionately high incidence in elderly patients. Disease symptoms range from mild diarrhea to life-threatening pseudomembranous colitis. Arou... Read More about Coinfection and Emergence of Rifamycin Resistance during a Recurrent Clostridium difficile Infection.
Bowel Disorders (2016)
Journal Article
Functional bowel disorders are highly prevalent disorders found worldwide. These disorders have the potential to affect all members of society, regardless of age, gender, race, creed, color or socioeconomic status. Improving our understanding of func... Read More about Bowel Disorders.
Corticotrophin releasing factor increases ascending colon volume after a fructose test meal in healthy humans: a randomised control trial (2016)
Journal Article
Background: Poorly absorbed, fermentable carbohydrates can provoke irritable bowel syndrome (IBS) symptoms by escaping absorption in the small bowel and being rapidly fermented in the colon in some susceptible subjects. IBS patients are often anxious... Read More about Corticotrophin releasing factor increases ascending colon volume after a fructose test meal in healthy humans: a randomised control trial.
Anticipation of thermal pain in diverticular disease (2016)
Journal Article
Background The relative importance of peripheral nerve injury or differences in central pain processing in painful diverticular disease (DD) is unclear. Functional MRI has demonstrated changes in the anticipation of pain in irritable bowel syndrom... Read More about Anticipation of thermal pain in diverticular disease.
Magnetic resonance imaging to evaluate gastrointestinal function (2015)
Journal Article
Magnetic resonance imaging biomarkers of gastrointestinal motor function and fluid distribution (2015)
Journal Article
Magnetic resonance imaging (MRI) is a well established technique that has revolutionized diagnostic radiology. Until recently, the impact that MRI has had in the assessment of gastrointestinal motor function and bowel fluid distribution in health and... Read More about Magnetic resonance imaging biomarkers of gastrointestinal motor function and fluid distribution.
Fat emulsion intragastric stability and droplet size modulate gastrointestinal responses and subsequent food intake in young adults (2015)
Journal Article
Background: Intragastric creaming and droplet size of fat emulsions may affect intragastric behavior and gastrointestinal and satiety responses. Objectives: We tested the hypotheses that gastrointestinal physiologic responses and satiety will be i... Read More about Fat emulsion intragastric stability and droplet size modulate gastrointestinal responses and subsequent food intake in young adults.
A mechanistic multi-centre, parallel group, randomised placebo controlled trial of Mesalazine for treatment of irritable bowel syndrome with diarrhoea (IBS-D) (2015)
Journal Article
Introduction: Immune activation has been reported in the mucosa of irritable bowel syndrome patients with diarrhoea (IBS-D) and some small studies have suggested that Mesalazine may reduce symptoms. We performed a double blind, randomised placebo con... Read More about A mechanistic multi-centre, parallel group, randomised placebo controlled trial of Mesalazine for treatment of irritable bowel syndrome with diarrhoea (IBS-D).
Effect of experimental stress on the small bowel and colon in healthy humans (2015)
Journal Article
Measurement of gastric meal and secretion volumes using magnetic resonance imaging (2015)
Journal Article
MRI can assess multiple gastric functions without ionizing radiation. However, time consuming image acquisition and analysis of gastric volume data, plus confounding of gastric emptying measurements by gastric secretions mixed with the test meal have... Read More about Measurement of gastric meal and secretion volumes using magnetic resonance imaging.
Effects of bowel cleansing on the intestinal microbiota (2014)
Journal Article
Objective: An adequate bowel cleansing is essential for a successful colonoscopy. Although purgative consumption is safe for the patient, there is little consensus on how the intestinal microbiota is affected by the procedure, especially regarding th... Read More about Effects of bowel cleansing on the intestinal microbiota.
Additive effects of gastric volumes and macronutrient composition on the sensation of postprandial fullness in humans (2014)
Journal Article
Background/Objectives: Intake of food or fluid distends the stomach and triggers mechanoreceptors and vagal afferents. Wall stretch and tension produces a feeling of fullness. Duodenal infusion studies assessing gastric sensitivity by barostat have s... Read More about Additive effects of gastric volumes and macronutrient composition on the sensation of postprandial fullness in humans.