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Exploring gastrointestinal variables affecting drug and formulation behavior: methodologies, challenges and opportunities

Hens, Bart; Corsetti, Maura; Spiller, Robin C.; Marciani, Luca; Vanuytsel, Tim; Tack, Jan; Talattof, Arjang; Amidon, Gordon L.; Koziolek, Mirko; Weitschies, Werner; Wilson, Clive G.; Bennink, Roelof J.; Brouwers, Joachim; Augustijns, Patrick

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Authors

Bart Hens

MAURA CORSETTI Maura.Corsetti@nottingham.ac.uk
Clinical Associate Professor

Robin C. Spiller

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LUCA MARCIANI LUCA.MARCIANI@NOTTINGHAM.AC.UK
Professor of Gastrointestinal Imaging

Tim Vanuytsel

Jan Tack

Arjang Talattof

Gordon L. Amidon

Mirko Koziolek

Werner Weitschies

Clive G. Wilson

Roelof J. Bennink

Joachim Brouwers

Patrick Augustijns



Abstract

Various gastrointestinal (GI) factors affect drug and formulation behavior after oral administration, including GI transfer, motility, pH and GI fluid volume and composition. An in-depth understanding of these physiological and anatomical variables is critical for a continued progress in oral drug development. In this review, different methodologies (invasive versus non-invasive) to explore the impact of physiological variables on formulation behavior in the human GI tract are presented, revealing their strengths and limitations. The techniques mentioned allow for an improved understanding of the role of following GI variables: gastric emptying (magnetic resonance imaging (MRI), scintigraphy, acetaminophen absorption technique, ultrasonography, breath test, intraluminal sampling and telemetry), motility (MRI, small intestinal/colonic manometry and telemetry), GI volume changes (MRI and ultrasonography), temperature (telemetry) and intraluminal pH (intraluminal sampling and telemetry).

Citation

Hens, B., Corsetti, M., Spiller, R. C., Marciani, L., Vanuytsel, T., Tack, J., …Augustijns, P. (2017). Exploring gastrointestinal variables affecting drug and formulation behavior: methodologies, challenges and opportunities. International Journal of Pharmaceutics, 519(1-2), https://doi.org/10.1016/j.ijpharm.2016.11.063

Journal Article Type Article
Acceptance Date Nov 29, 2016
Online Publication Date Nov 30, 2016
Publication Date Mar 15, 2017
Deposit Date Jan 20, 2017
Publicly Available Date Mar 29, 2024
Journal International Journal of Pharmaceutics
Print ISSN 0378-5173
Electronic ISSN 1873-3476
Publisher Elsevier
Peer Reviewed Peer Reviewed
Volume 519
Issue 1-2
DOI https://doi.org/10.1016/j.ijpharm.2016.11.063
Keywords Intestinal absorption, MRI, Scintigraphy, Manometry, Telemetry, Intraluminal profiling
Public URL https://nottingham-repository.worktribe.com/output/850453
Publisher URL http://www.sciencedirect.com/science/article/pii/S0378517316311267

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