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Intragastric infusion of denatonium benzoate attenuates interdigestive gastric motility and hunger scores in healthy female volunteers

Deloose, Eveline; Janssen, Pieter; Corsetti, Maura; Biesiekierski, Jessica; Masuy, Imke; Rotondo, Alessandra; Van Oudenhove, Lukas; Depoortere, Inge; Tack, Jan

Authors

Eveline Deloose

Pieter Janssen

MAURA CORSETTI Maura.Corsetti@nottingham.ac.uk
Clinical Associate Professor

Jessica Biesiekierski

Imke Masuy

Alessandra Rotondo

Lukas Van Oudenhove

Inge Depoortere

Jan Tack



Abstract

Background: Denatonium benzoate (DB) has been shown to influence ongoing ingestive behavior and gut peptide secretion.
Objective: We studied how the intragastric administration of DB affects interdigestive motility, motilin and ghrelin plasma concentrations, hunger and satiety ratings, and food intake in healthy volunteers.
Design: Lingual bitter taste sensitivity was tested with the use of 6 concentrations of DB in 65 subjects. A placebo or 1 μmol DB/kg was given intragastrically to assess its effect on fasting gastrointestinal motility and hunger ratings, motilin and ghrelin plasma concentrations, satiety, and caloric intake.
Results: Women (n = 39) were more sensitive toward a lingual bitter stimulus (P = 0.005) than men (n = 26). In women (n = 10), intragastric DB switched the origin of phase III contractions from the stomach to the duodenum (P = 0.001) and decreased hunger ratings (P = 0.04). These effects were not observed in men (n = 10). In women (n = 12), motilin (P = 0.04) plasma concentrations decreased after intragastric DB administration, whereas total and octanoylated ghrelin were not affected. The intragastric administration of DB decreased hunger (P = 0.008) and increased satiety ratings (P = 0.01) after a meal (500 kcal) in 13 women without affecting gastric emptying in 6 women. Caloric intake tended to decrease after DB administration compared with the placebo (mean ± SEM: 720 ± 58 compared with 796 ± 45 kcal; P = 0.08) in 20 women.
Conclusions: Intragastric DB administration decreases both antral motility and hunger ratings during the fasting state, possibly because of a decrease in motilin release. Moreover, DB decreases hunger and increases satiety ratings after a meal and shows potential for decreasing caloric intake

Citation

Deloose, E., Janssen, P., Corsetti, M., Biesiekierski, J., Masuy, I., Rotondo, A., …Tack, J. (2017). Intragastric infusion of denatonium benzoate attenuates interdigestive gastric motility and hunger scores in healthy female volunteers. American Journal of Clinical Nutrition, 105(3), 580-588. https://doi.org/10.3945/ajcn.116.138297

Journal Article Type Article
Acceptance Date Dec 19, 2016
Online Publication Date Feb 1, 2017
Publication Date 2017-03
Deposit Date Apr 13, 2017
Publicly Available Date Mar 28, 2024
Journal American Journal of Clinical Nutrition
Print ISSN 0002-9165
Electronic ISSN 1938-3207
Publisher Oxford University Press
Peer Reviewed Peer Reviewed
Volume 105
Issue 3
Pages 580-588
DOI https://doi.org/10.3945/ajcn.116.138297
Keywords Bitter, hunger, migrating motor complex, motilin,denatonium benzoate
Public URL https://nottingham-repository.worktribe.com/output/837102
Publisher URL https://academic.oup.com/ajcn/article/105/3/580/4569699

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