Bowel Disorders

Lacy, Brian E.; Mearin, Ferm�n; Chang, Lin; Chey, William D.; Lembo, Anthony J.; Simren, Magnus; Spiller, Robin

Abstract

Functional bowel disorders are highly prevalent disorders found worldwide. These disorders have the potential to affect all members of society, regardless of age, gender, race, creed, color or socioeconomic status. Improving our understanding of functional bowel disorders (FBD) is critical as they impose a negative economic impact to the global health care system in addition to reducing quality of life. Research in the basic and clinical sciences during the past decade has produced new information on the epidemiology, etiology, pathophysiology, diagnosis and treatment of FBDs. These important findings created a need to revise the Rome III criteria for FBDs, last published in 2006. This manuscript classifies the FBDs into five distinct categories: irritable bowel syndrome (IBS); functional constipation (FC); functional diarrhea (FDr); functional abdominal bloating/distention (FAB/D); and unspecified FBD (U-FBD). Also included in this article is a new sixth category, opioid induced constipation (OIC) which is distinct from the functional bowel disorders (FBDs). Each disorder will first be defined, followed by sections on epidemiology, rationale for changes from prior criteria, clinical evaluation, physiologic features, psychosocial features and treatment. It is the hope of this committee that this new information will assist both clinicians and researchers in the decade to come

Citation

Lacy, B. E., Mearin, F., Chang, L., Chey, W. D., Lembo, A. J., Simren, M., & Spiller, R. (2016). Bowel Disorders. Gastroenterology, 150(6), 1393-1407.e5. https://doi.org/10.1053/j.gastro.2016.02.031

• Journal Article Type: Article
• Acceptance Date: May 4, 2016
• Online Publication Date: May 1, 2016
• Publication Date: May 1, 2016
• Deposit Date: Nov 26, 2020
• Publicly Available Date: Nov 27, 2020
• Journal: Gastroenterology
• Print ISSN: 0016-5085
• Electronic ISSN: 1528-0012
• Publisher: Elsevier
• Peer Reviewed: Peer Reviewed
• Volume: 150
• Issue: 6
• Pages: 1393-1407.e5
• DOI: https://doi.org/10.1053/j.gastro.2016.02.031
• Keywords: Gastroenterology
• Public URL: https://nottingham-repository.worktribe.com/output/5070613
• Publisher URL: https://www.gastrojournal.org/article/S0016-5085(16)00222-5/fulltext
• Related Public URLs: https://www.sciencedirect.com/science/article/abs/pii/S0016508516002225
• Additional Information: This article is maintained by: Elsevier; Article Title: Bowel Disorders; Journal Title: Gastroenterology; CrossRef DOI link to publisher maintained version: https://doi.org/10.1053/j.gastro.2016.02.031; Content Type: article; Copyright: © 2016 The AGA Institute.